Grant S - Search Results

1

Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1.

Blasina A, Hallin J, Chen E, Arango ME, Kraynov E, Register J, Grant S, Ninkovic S, Chen P, Nichols T, O'Connor P, Anderes K. Blasina A, et al. Among authors: grant s. Mol Cancer Ther. 2008 Aug;7(8):2394-404. doi: 10.1158/1535-7163.MCT-07-2391. Mol Cancer Ther. 2008. PMID: 18723486

2

Structure-based design and synthesis of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors.

Teng M, Zhu J, Johnson MD, Chen P, Kornmann J, Chen E, Blasina A, Register J, Anderes K, Rogers C, Deng Y, Ninkovic S, Grant S, Hu Q, Lundgren K, Peng Z, Kania RS. Teng M, et al. Among authors: grant s. J Med Chem. 2007 Nov 1;50(22):5253-6. doi: 10.1021/jm0704604. Epub 2007 Sep 21. J Med Chem. 2007. PMID: 17887663

3

Characterization of the CHK1 allosteric inhibitor binding site.

Vanderpool D, Johnson TO, Ping C, Bergqvist S, Alton G, Phonephaly S, Rui E, Luo C, Deng YL, Grant S, Quenzer T, Margosiak S, Register J, Brown E, Ermolieff J. Vanderpool D, et al. Among authors: grant s. Biochemistry. 2009 Oct 20;48(41):9823-30. doi: 10.1021/bi900258v. Biochemistry. 2009. PMID: 19743875

4

Study of the PDK1/AKT signaling pathway using selective PDK1 inhibitors, HCS, and enhanced biochemical assays.

Hofler A, Nichols T, Grant S, Lingardo L, Esposito EA, Gridley S, Murphy ST, Kath JC, Cronin CN, Kraus M, Alton G, Xie Z, Sutton S, Gehring M, Ermolieff J. Hofler A, et al. Among authors: grant s. Anal Biochem. 2011 Jul 15;414(2):179-86. doi: 10.1016/j.ab.2011.03.013. Epub 2011 Mar 12. Anal Biochem. 2011. PMID: 21402045

5

Identification of novel pyrrolopyrazoles as protein kinase C β II inhibitors.

Li H, Hong Y, Nukui S, Lou J, Johnson S, Scales S, Botrous I, Tompkins E, Yin C, Zhou R, He M, Jensen J, Bouzida D, Alton G, Lafontaine J, Grant S. Li H, et al. Among authors: grant s. Bioorg Med Chem Lett. 2011 Jan 1;21(1):584-7. doi: 10.1016/j.bmcl.2010.10.032. Epub 2010 Oct 13. Bioorg Med Chem Lett. 2011. PMID: 21084194

6

Discovery of a novel class of targeted kinase inhibitors that blocks protein kinase C signaling and ameliorates retinal vascular leakage in a diabetic rat model.

Grant S, Tran P, Zhang Q, Zou A, Dinh D, Jensen J, Zhou S, Kang X, Zachwieja J, Lippincott J, Liu K, Johnson SL, Scales S, Yin C, Nukui S, Stoner C, Prasanna G, Lafontaine J, Wells P, Li H. Grant S, et al. Eur J Pharmacol. 2010 Feb 10;627(1-3):16-25. doi: 10.1016/j.ejphar.2009.10.029. Epub 2009 Oct 20. Eur J Pharmacol. 2010. PMID: 19850035

7

Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors.

Falk MD, Liu W, Bolaños B, Unsal-Kacmaz K, Klippel A, Grant S, Brooun A, Timofeevski S. Falk MD, et al. Among authors: grant s. Biosci Rep. 2014 Apr 1;34(2):e00097. doi: 10.1042/BSR20140010. Print 2014 Apr 1. Biosci Rep. 2014. PMID: 27919031 Free PMC article.

8

Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor.

Grodsky N, Li Y, Bouzida D, Love R, Jensen J, Nodes B, Nonomiya J, Grant S. Grodsky N, et al. Among authors: grant s. Biochemistry. 2006 Nov 28;45(47):13970-81. doi: 10.1021/bi061128h. Biochemistry. 2006. PMID: 17115692

9

Substrate-specific conformational regulation of the receptor tyrosine kinase VEGFR2 catalytic domain.

Solowiej J, Chen JH, Zou HY, Grant SK, Murray BW. Solowiej J, et al. ACS Chem Biol. 2013 May 17;8(5):978-86. doi: 10.1021/cb400040z. Epub 2013 Mar 6. ACS Chem Biol. 2013. PMID: 23441851

10

Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A.

Quinlan CL, Kaiser SE, Bolaños B, Nowlin D, Grantner R, Karlicek-Bryant S, Feng JL, Jenkinson S, Freeman-Cook K, Dann SG, Wang X, Wells PA, Fantin VR, Stewart AE, Grant SK. Quinlan CL, et al. Among authors: grant sk. Nat Chem Biol. 2017 Jul;13(7):785-792. doi: 10.1038/nchembio.2384. Epub 2017 May 29. Nat Chem Biol. 2017. PMID: 28553945

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