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Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes.
Winters MP, Sui Z, Wall M, Wang Y, Gunnet J, Leonard J, Hua H, Yan W, Suckow A, Bell A, Clapper W, Jenkinson C, Haug P, Koudriakova T, Huebert N, Murray WV. Winters MP, et al. Among authors: hua h. Bioorg Med Chem Lett. 2018 Mar 1;28(5):841-846. doi: 10.1016/j.bmcl.2018.02.013. Epub 2018 Feb 8. Bioorg Med Chem Lett. 2018. PMID: 29456108
Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes.
Zhang X, Cai C, Sui Z, Macielag M, Wang Y, Yan W, Suckow A, Hua H, Bell A, Haug P, Clapper W, Jenkinson C, Gunnet J, Leonard J, Murray WV. Zhang X, et al. Among authors: hua h. ACS Med Chem Lett. 2017 Jul 27;8(9):947-952. doi: 10.1021/acsmedchemlett.7b00233. eCollection 2017 Sep 14. ACS Med Chem Lett. 2017. PMID: 28947942 Free PMC article.
Erratum to "Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes" Bioorg. Med. Chem. Lett. 28 (2018) [841-846].
Winters MP, Sui Z, Wall M, Wang Y, Gunnet J, Leonard J, Hua H, Yan W, Suckow A, Bell A, Clapper W, Jenkinson C, Haug P, Koudriakova T, Huebert N, Murray WV. Winters MP, et al. Among authors: hua h. Bioorg Med Chem Lett. 2018 May 15;28(9):1676-1678. doi: 10.1016/j.bmcl.2018.03.053. Epub 2018 Mar 28. Bioorg Med Chem Lett. 2018. PMID: 29605534 No abstract available.
Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists.
Zhang X, Cai C, Winters M, Wells M, Wall M, Lanter J, Sui Z, Ma J, Novack A, Nashashibi I, Wang Y, Yan W, Suckow A, Hua H, Bell A, Haug P, Clapper W, Jenkinson C, Gunnet J, Leonard J, Murray WV. Zhang X, et al. Among authors: hua h. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3272-3278. doi: 10.1016/j.bmcl.2017.06.028. Epub 2017 Jun 12. Bioorg Med Chem Lett. 2017. PMID: 28642104
Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase inhibitor.
Barrett TD, Palomino HL, Brondstetter TI, Kanelakis KC, Wu X, Haug PV, Yan W, Young A, Hua H, Hart JC, Tran DT, Venkatesan H, Rosen MD, Peltier HM, Sepassi K, Rizzolio MC, Bembenek SD, Mirzadegan T, Rabinowitz MH, Shankley NP. Barrett TD, et al. Among authors: hua h. Mol Pharmacol. 2011 Jun;79(6):910-20. doi: 10.1124/mol.110.070508. Epub 2011 Mar 3. Mol Pharmacol. 2011. PMID: 21372172
Gastroblastoma with an ACTB-GLI1 gene fusion in a 39-year-old man.
Huang L, Hu D, Hua H, Si X. Huang L, et al. Among authors: hua h. Dig Liver Dis. 2024 Apr 30:S1590-8658(24)00350-5. doi: 10.1016/j.dld.2024.04.006. Online ahead of print. Dig Liver Dis. 2024. PMID: 38693033 No abstract available.
1,442 results