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Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection.
Hariharan VN, Shin M, Chang CW, O'Reilly D, Biscans A, Yamada K, Guo Z, Somasundaran M, Tang Q, Monopoli K, Krishnamurthy PM, Devi G, McHugh N, Cooper DA, Echeverria D, Cruz J, Chan IL, Liu P, Lim SY, McConnell J, Singh SP, Hildebrand S, Sousa J, Davis SM, Kennedy Z, Ferguson C, Godinho BMDC, Thillier Y, Caiazzi J, Ly S, Muhuri M, Kelly K, Humphries F, Cousineau A, Parsi KM, Li Q, Wang Y, Maehr R, Gao G, Korkin D, McDougall WM, Finberg RW, Fitzgerald KA, Wang JP, Watts JK, Khvorova A. Hariharan VN, et al. Among authors: humphries f. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2219523120. doi: 10.1073/pnas.2219523120. Epub 2023 Mar 9. Proc Natl Acad Sci U S A. 2023. PMID: 36893269 Free PMC article.
Assembling the Inflammasome, Piece by Piece.
Humphries F, Fitzgerald KA. Humphries F, et al. J Immunol. 2019 Sep 1;203(5):1093-1094. doi: 10.4049/jimmunol.1900764. J Immunol. 2019. PMID: 31427397 No abstract available.
Loosening the grip on nuclear cGAS.
Humphries F, Fitzgerald KA. Humphries F, et al. Nat Genet. 2020 Dec;52(12):1269-1270. doi: 10.1038/s41588-020-00746-2. Nat Genet. 2020. PMID: 33230301 No abstract available.
Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants.
Li Q, Humphries F, Girardin RC, Wallace A, Ejemel M, Amcheslavsky A, McMahon CT, Schiller ZA, Ma Z, Cruz J, Dupuis AP, Payne AF, Maryam A, Yilmaz NK, McDonough KA, Pierce BG, Schiffer CA, Kruse AC, Klempner MS, Cavacini LA, Fitzgerald KA, Wang Y. Li Q, et al. Among authors: humphries f. Front Immunol. 2022 Sep 12;13:995412. doi: 10.3389/fimmu.2022.995412. eCollection 2022. Front Immunol. 2022. PMID: 36172366 Free PMC article.
Targeting STING oligomerization with small-molecule inhibitors.
Humphries F, Shmuel-Galia L, Jiang Z, Zhou JY, Barasa L, Mondal S, Wilson R, Sultana N, Shaffer SA, Ng SL, Pesiridis GS, Thompson PR, Fitzgerald KA. Humphries F, et al. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2305420120. doi: 10.1073/pnas.2305420120. Epub 2023 Aug 7. Proc Natl Acad Sci U S A. 2023. PMID: 37549268 Free PMC article.
Development of LB244, an Irreversible STING Antagonist.
Barasa L, Chaudhuri S, Zhou JY, Jiang Z, Choudhary S, Green RM, Wiggin E, Cameron M, Humphries F, Fitzgerald KA, Thompson PR. Barasa L, et al. Among authors: humphries f. J Am Chem Soc. 2023 Sep 20;145(37):20273-20288. doi: 10.1021/jacs.3c03637. Epub 2023 Sep 11. J Am Chem Soc. 2023. PMID: 37695732
Cellular nucleic acid-binding protein restricts SARS-CoV-2 by regulating interferon and disrupting RNA-protein condensates.
Chen Y, Lei X, Jiang Z, Humphries F, Parsi KM, Mustone NJ, Ramos I, Mutetwa T, Fernandez-Sesma A, Maehr R, Caffrey DR, Fitzgerald KA. Chen Y, et al. Among authors: humphries f. Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2308355120. doi: 10.1073/pnas.2308355120. Epub 2023 Nov 14. Proc Natl Acad Sci U S A. 2023. PMID: 37963251 Free PMC article.
46 results