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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1977 2
1978 1
1980 1
1982 1
1983 2
1984 3
1985 1
1986 2
1987 1
1988 2
1990 1
1991 2
1992 5
1993 4
1994 1
1995 2
1996 4
1997 3
1998 5
1999 5
2000 1
2001 2
2002 3
2003 3
2004 1
2006 1
2007 1
2008 3
2009 12
2010 39
2011 64
2012 109
2013 96
2014 95
2015 111
2016 100
2017 114
2018 130
2019 132
2020 126
2021 136
2022 106
2023 117
2024 36

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1,397 results

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Page 1
IDH1 and IDH2 mutations in gliomas.
Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW, Velculescu VE, Vogelstein B, Bigner DD. Yan H, et al. N Engl J Med. 2009 Feb 19;360(8):765-73. doi: 10.1056/NEJMoa0808710. N Engl J Med. 2009. PMID: 19228619 Free PMC article.
METHODS: We determined the sequence of the IDH1 gene and the related IDH2 gene in 445 central nervous system (CNS) tumors and 494 non-CNS tumors. ...Tumors without mutations in IDH1 often had mutations affecting the analogous amino acid (R172) of the IDH2 …
METHODS: We determined the sequence of the IDH1 gene and the related IDH2 gene in 445 central nervous system (CNS) tumo …
IDH2 gene deficiency accelerates unilateral ureteral obstruction-induced kidney inflammation through oxidative stress and activation of macrophages.
Kim JI, Noh MR, Yoon GE, Jang HS, Kong MJ, Park KM. Kim JI, et al. Korean J Physiol Pharmacol. 2021 Mar 1;25(2):139-146. doi: 10.4196/kjpp.2021.25.2.139. Korean J Physiol Pharmacol. 2021. PMID: 33602884 Free PMC article.
Ureteral obstruction induces kidney inflammation and fibrosis via oxidative stress. Here, we investigated the role and underlying mechanism of IDH2 in unilateral ureteral obstruction (UUO)-induced kidney inflammation using IDH2 gene deleted mice (IDH2( …
Ureteral obstruction induces kidney inflammation and fibrosis via oxidative stress. Here, we investigated the role and underlying mechanism …
[Research Advances of IDH2 Gene Mutation in Acute Myeloid Leukemia].
Zhao YX, Shen XL. Zhao YX, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 Apr;24(2):632-6. doi: 10.7534/j.issn.1009-2137.2016.02.061. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016. PMID: 27151043 Review. Chinese.
Acute myeloid leukemia (AML) is a malignant clonal hematologic disease from hematopoietic stem and progenitor cells. The isocitrate dehychogenase 2 (IDH2) gene mutation has been recently found, which may be associated with the course of AML. The incidence of IDH2 …
Acute myeloid leukemia (AML) is a malignant clonal hematologic disease from hematopoietic stem and progenitor cells. The isocitrate dehychog …
IDH2 mutations in acute myeloid leukemia.
Babakhanlou R, DiNardo C, Borthakur G. Babakhanlou R, et al. Leuk Lymphoma. 2023 Nov-Dec;64(11):1733-1741. doi: 10.1080/10428194.2023.2237153. Epub 2023 Jul 18. Leuk Lymphoma. 2023. PMID: 37462435 Review.
With an improved understanding of the pathophysiology of the disease, the advent of new treatment options has enriched the armamentarium of the physician to combat the disease. Mutations of the isocitrate dehydrogenase (IDHs) genes are common in AML and occur in 20-30% of …
With an improved understanding of the pathophysiology of the disease, the advent of new treatment options has enriched the armamentarium of …
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, Li Y, Bhagwat N, Vasanthakumar A, Fernandez HF, Tallman MS, Sun Z, Wolniak K, Peeters JK, Liu W, Choe SE, Fantin VR, Paietta E, Löwenberg B, Licht JD, Godley LA, Delwel R, Valk PJ, Thompson CB, Levine RL, Melnick A. Figueroa ME, et al. Cancer Cell. 2010 Dec 14;18(6):553-67. doi: 10.1016/j.ccr.2010.11.015. Epub 2010 Dec 9. Cancer Cell. 2010. PMID: 21130701 Free PMC article.
Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML.
DiNardo CD, Tiong IS, Quaglieri A, MacRaild S, Loghavi S, Brown FC, Thijssen R, Pomilio G, Ivey A, Salmon JM, Glytsou C, Fleming SA, Zhang Q, Ma H, Patel KP, Kornblau SM, Xu Z, Chua CC, Chen X, Blombery P, Flensburg C, Cummings N, Aifantis I, Kantarjian H, Huang DCS, Roberts AW, Majewski IJ, Konopleva M, Wei AH. DiNardo CD, et al. Blood. 2020 Mar 12;135(11):791-803. doi: 10.1182/blood.2019003988. Blood. 2020. PMID: 31932844 Free PMC article.
High response rates and durable remissions were typically associated with NPM1 or IDH2 mutations, with prolonged molecular remissions prevalent for NPM1 mutations. ...
High response rates and durable remissions were typically associated with NPM1 or IDH2 mutations, with prolonged molecular remissions …
Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma.
Zhang P, Zhang M. Zhang P, et al. Clin Epigenetics. 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. Clin Epigenetics. 2020. PMID: 33160401 Free PMC article. Review.
Histone modification alters the level of gene expression by regulating the acetylation status of lysine residues on the promoter surrounding histones, often leading to the silencing of tumour suppressor genes or the overexpression of proto-oncogenes in lymphoma. DNA …
Histone modification alters the level of gene expression by regulating the acetylation status of lysine residues on the promoter surr …
IDH2 inhibition in AML: Finally progress?
Stein EM. Stein EM. Best Pract Res Clin Haematol. 2015 Jun-Sep;28(2-3):112-5. doi: 10.1016/j.beha.2015.10.016. Epub 2015 Oct 19. Best Pract Res Clin Haematol. 2015. PMID: 26590767 Review.
Mutations in the active site of IDH1 at position R132 and an analogous mutation in the IDH2 gene at position R172 have been discovered. Notably, many cases of acute myeloid leukemia (AML) have mutations in R172 and R140. The impact of these mutations and early resul …
Mutations in the active site of IDH1 at position R132 and an analogous mutation in the IDH2 gene at position R172 have been di …
Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis.
Yoshimi A, Lin KT, Wiseman DH, Rahman MA, Pastore A, Wang B, Lee SC, Micol JB, Zhang XJ, de Botton S, Penard-Lacronique V, Stein EM, Cho H, Miles RE, Inoue D, Albrecht TR, Somervaille TCP, Batta K, Amaral F, Simeoni F, Wilks DP, Cargo C, Intlekofer AM, Levine RL, Dvinge H, Bradley RK, Wagner EJ, Krainer AR, Abdel-Wahab O. Yoshimi A, et al. Nature. 2019 Oct;574(7777):273-277. doi: 10.1038/s41586-019-1618-0. Epub 2019 Oct 2. Nature. 2019. PMID: 31578525 Free PMC article.
Transcription and pre-mRNA splicing are key steps in the control of gene expression and mutations in genes regulating each of these processes are common in leukaemia(1,2). ...Whereas mutations in either IDH2 or SRSF2 imparted distinct splicing changes, co-exp …
Transcription and pre-mRNA splicing are key steps in the control of gene expression and mutations in genes regulating each of …
Determination of IDH1, IDH2, MGMT, TERT and ATRX Gene Mutations in Glial Tumors.
Yaltirik CK, Yilmaz SG, Ozdogan S, Bilgin EY, Barut Z, Ture U, Isbir T. Yaltirik CK, et al. In Vivo. 2022 Jul-Aug;36(4):1694-1702. doi: 10.21873/invivo.12881. In Vivo. 2022. PMID: 35738587 Free PMC article.
The aim of our study was to evaluate isocitrate dehydrogenase 1 and 2 (IDH1, IDH2), telomerase reverse transcriptase (TERT), O-6- methylguanine-DNA methyltransferase (MGMT) and alpha-thalassemia/mental retardation, X-linked (ATRX) genes with next-generation sequenci …
The aim of our study was to evaluate isocitrate dehydrogenase 1 and 2 (IDH1, IDH2), telomerase reverse transcriptase (TERT), O-6- met …
1,397 results