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Page 1
Molecular Pathways: Interleukin-35 in Autoimmunity and Cancer.
Pylayeva-Gupta Y. Pylayeva-Gupta Y. Clin Cancer Res. 2016 Oct 15;22(20):4973-4978. doi: 10.1158/1078-0432.CCR-16-0743. Epub 2016 Aug 31. Clin Cancer Res. 2016. PMID: 27582486 Review.
Recent studies have revealed that by directing de novo generation of regulatory T and B cells and inhibiting T effector responses, IL35 plays an important role in the development of autoimmune diseases and cancer. IL35 is overexpressed in a variety of cancers and ma …
Recent studies have revealed that by directing de novo generation of regulatory T and B cells and inhibiting T effector responses, IL35 play …
IL-36alpha suppresses proliferation of ovarian cancer cells.
Chang L, Guo R, Yuan Z. Chang L, et al. Tumour Biol. 2017 Jun;39(6):1010428317706918. doi: 10.1177/1010428317706918. Tumour Biol. 2017. PMID: 28621240 Free article.
Interleukin-36alpha (IL-36alpha), also formerly known as IL-1F6, is pertaining to IL-1 family members that has been shown to play an important pro-inflammatory role in chronic immune disorders. However, the role IL-36alpha in the setting of cancer remains unknown. Here, in …
Interleukin-36alpha (IL-36alpha), also formerly known as IL-1F6, is pertaining to IL-1 family members that has been shown to play an importa …
IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic.
Dong H, Hao Y, Li W, Yang W, Gao P. Dong H, et al. Front Immunol. 2022 Jul 12;13:921275. doi: 10.3389/fimmu.2022.921275. eCollection 2022. Front Immunol. 2022. PMID: 35903102 Free PMC article. Review.
Abnormal levels of IL-36 cytokine expression are involved in the pathogenesis of inflammation, autoimmunity, allergy and cancer. The present study provides a summary of recent reports on IL-36 cytokines that participate in the pathogenesis of inflammatory diseases, and the …
Abnormal levels of IL-36 cytokine expression are involved in the pathogenesis of inflammation, autoimmunity, allergy and cancer. The …
Immune Regulation by T Regulatory Cells in Hepatitis B Virus-Related Inflammation and Cancer.
Trehanpati N, Vyas AK. Trehanpati N, et al. Scand J Immunol. 2017 Mar;85(3):175-181. doi: 10.1111/sji.12524. Scand J Immunol. 2017. PMID: 28109025 Free article. Review.
Hepatocellular carcinoma (HCC) is the leading cause of cancer death, and hepatitis B virus (HBV) infection is one of the commonest causes in Asian countries. ...
Hepatocellular carcinoma (HCC) is the leading cause of cancer death, and hepatitis B virus (HBV) infection is one of the commonest ca …
Interleukin-36alpha suppresses growth of non-small cell lung cancer in vitro by reducing angiogenesis.
Xie X, Hu H, He J, Liu Y, Guo F, Luo F, Jiang M, Wang L. Xie X, et al. FEBS Open Bio. 2021 May;11(5):1353-1363. doi: 10.1002/2211-5463.13141. Epub 2021 May 2. FEBS Open Bio. 2021. PMID: 33713575 Free PMC article.
Recently, several studies have indicated that IL-36alpha has potential anticancer effects against certain types of cancer. However, the expression pattern and functional role of IL-36alpha in non-small cell lung cancer (NSCLC) have not been elucidated. ...Intratumor …
Recently, several studies have indicated that IL-36alpha has potential anticancer effects against certain types of cancer. However, t …
Decreased expression of interleukin-36alpha predicts poor prognosis in colorectal cancer patients.
Wang ZS, Cong ZJ, Luo Y, Mu YF, Qin SL, Zhong M, Chen JJ. Wang ZS, et al. Int J Clin Exp Pathol. 2014 Oct 15;7(11):8077-81. eCollection 2014. Int J Clin Exp Pathol. 2014. PMID: 25550854 Free PMC article.
Interleukin-36alpha (IL-36alpha), previously designated as IL-1F6, has been found to have a pathogenic role in psoriasis. However, possible functions of IL-36alpha in cancer remain unclear. In present study, we investigate the possible role of interleukin-36alpha involved …
Interleukin-36alpha (IL-36alpha), previously designated as IL-1F6, has been found to have a pathogenic role in psoriasis. However, possible …
Interleukin-36alpha inhibits colorectal cancer metastasis by enhancing the infiltration and activity of CD8(+) T lymphocytes.
Wei X, Yao Y, Wang X, Sun J, Zhao W, Qiu L, Zhai W, Qi Y, Gao Y, Wu Y. Wei X, et al. Int Immunopharmacol. 2021 Nov;100:108152. doi: 10.1016/j.intimp.2021.108152. Epub 2021 Sep 21. Int Immunopharmacol. 2021. PMID: 34555640
Colorectal cancer is one of the deadliest cancers, and the discovery of new diagnostic biomarkers and therapeutic targets is vital. ...
Colorectal cancer is one of the deadliest cancers, and the discovery of new diagnostic biomarkers and therapeutic targets is v …
IL-36 cytokines in inflammatory and malignant diseases: not the new kid on the block anymore.
Byrne J, Baker K, Houston A, Brint E. Byrne J, et al. Cell Mol Life Sci. 2021 Sep;78(17-18):6215-6227. doi: 10.1007/s00018-021-03909-4. Epub 2021 Aug 7. Cell Mol Life Sci. 2021. PMID: 34365521 Free PMC article. Review.
In the disease context, over activation of IL-36 has now been associated with many inflammatory diseases including Psoriasis and inflammatory bowel diseases, with roles in cancer also now being investigated. This review summarises the current knowledge of IL-36 biology, it …
In the disease context, over activation of IL-36 has now been associated with many inflammatory diseases including Psoriasis and inflammator …
Uncovering novel drug targets for bipolar disorder: a Mendelian randomization analysis of brain, cerebrospinal fluid, and plasma proteomes.
Jia T, Liu T, Hu S, Li Y, Chen P, Qin F, He Y, Han F, Zhang C. Jia T, et al. Psychol Med. 2024 May 9:1-11. doi: 10.1017/S0033291724001077. Online ahead of print. Psychol Med. 2024. PMID: 38720515
In cerebrospinal fluid, increased BD risk was associated with increased levels of FRZB, AGRP, and IL36A and decreased CTSF and LRP8. Plasma analysis revealed that decreased LMAN2L, CX3CL1, PI3, NCAM1, and TIMP4 correlated with increased BD risk, but ITIH1 did not. ...
In cerebrospinal fluid, increased BD risk was associated with increased levels of FRZB, AGRP, and IL36A and decreased CTSF and LRP8. …
IL-36 s in the colorectal cancer: is interleukin 36 good or bad for the development of colorectal cancer?
Chen F, Qu M, Zhang F, Tan Z, Xia Q, Hambly BD, Bao S, Tao K. Chen F, et al. BMC Cancer. 2020 Feb 3;20(1):92. doi: 10.1186/s12885-020-6587-z. BMC Cancer. 2020. PMID: 32013927 Free PMC article.
BACKGROUND AND AIMS: Colorectal cancer (CRC) is a major killer. Host immunity is important in tumorigenesis. ...Using immunohistochemistry/histopathology, IL-36alpha, IL-36beta and IL-36gamma were determined, in comparison to non-cancer tissues. RESULTS: A significa …
BACKGROUND AND AIMS: Colorectal cancer (CRC) is a major killer. Host immunity is important in tumorigenesis. ...Using immunohistochem …
20 results