Uncovering novel drug targets for bipolar disorder: a Mendelian randomization analysis of brain, cerebrospinal fluid, and plasma proteomes.
Jia T, Liu T, Hu S, Li Y, Chen P, Qin F, He Y, Han F, Zhang C.
Jia T, et al.
Psychol Med. 2024 May 9:1-11. doi: 10.1017/S0033291724001077. Online ahead of print.
Psychol Med. 2024.
PMID: 38720515
In cerebrospinal fluid, increased BD risk was associated with increased levels of FRZB, AGRP, and IL36A and decreased CTSF and LRP8. Plasma analysis revealed that decreased LMAN2L, CX3CL1, PI3, NCAM1, and TIMP4 correlated with increased BD risk, but ITIH1 did not. ...
In cerebrospinal fluid, increased BD risk was associated with increased levels of FRZB, AGRP, and IL36A and decreased CTSF and LRP8. …