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1946 1
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1958 7
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1992 2
1993 1
1995 5
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2011 6
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2020 3
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2024 0

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102 results

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Page 1
Sarin (GB, O-isopropyl methylphosphonofluoridate) neurotoxicity: critical review.
Abou-Donia MB, Siracuse B, Gupta N, Sobel Sokol A. Abou-Donia MB, et al. Crit Rev Toxicol. 2016 Nov;46(10):845-875. doi: 10.1080/10408444.2016.1220916. Epub 2016 Oct 5. Crit Rev Toxicol. 2016. PMID: 27705071 Free PMC article. Review.
Sarin (GB, O-isopropyl methylphosphonofluoridate) is a potent organophosphorus (OP) nerve agent that inhibits acetylcholinesterase (AChE) irreversibly. ...Accumulation of ACh at peripheral autonomic synapses leads to peripheral signs of intoxication and overstimulation of …
Sarin (GB, O-isopropyl methylphosphonofluoridate) is a potent organophosphorus (OP) nerve agent that inhibits acetylcholinesterase (A …
Diaqua-bis-[2-(5-isopropyl-5-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)nicotinato]cobalt(II).
Zhang Z, Liu JZ, Gao P, Huang ZJ. Zhang Z, et al. Acta Crystallogr Sect E Struct Rep Online. 2010 Nov 13;66(Pt 12):m1544-5. doi: 10.1107/S1600536810044715. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21589239 Free PMC article.
In the title complex, [Co(C(13)H(14)N(3)O(3))(2)(H(2)O)(2)], the Co(II) atom has a distorted octa-hedral coordination, formed by four N atoms from two ()-2-(5-isopropyl-5-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)nicotinate ligands and two O atoms from two water mol …
In the title complex, [Co(C(13)H(14)N(3)O(3))(2)(H(2)O)(2)], the Co(II) atom has a distorted octa-hedral coordination, formed by four N atom …
Diaqua-bis-[2-(5-isopropyl-5-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl-kappaN)nicotinato-kappaN]manganese(II).
Gao P, Liu JZ, Zhang Z, Huang ZJ. Gao P, et al. Acta Crystallogr Sect E Struct Rep Online. 2010 Nov 27;66(Pt 12):m1668. doi: 10.1107/S1600536810048506. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21589328 Free PMC article.
In the title compound, [Mn(C(13)H(14)N(3)O(3))(2)(H(2)O)(2)], the Mn(II) ion is coordinated by four N atoms from two ()-2-(5-isopropyl-5-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)nicotinate ligands and two water mol-ecules in a distorted octa-hedral environment. ...
In the title compound, [Mn(C(13)H(14)N(3)O(3))(2)(H(2)O)(2)], the Mn(II) ion is coordinated by four N atoms from two ()-2-(5-isopropyl …
Nicotinate esters: their binding to and hydrolysis by human serum albumin.
Steiner A, Mayer JM, Testa B. Steiner A, et al. J Pharm Pharmacol. 1992 Sep;44(9):745-9. doi: 10.1111/j.2042-7158.1992.tb05512.x. J Pharm Pharmacol. 1992. PMID: 1360527
Nicotinate esters were studied for their binding to, and hydrolysis by, human serum albumin. ...Only p-methoxyphenyl nicotinate was both a ligand and a substrate, and its rate constants of binding and hydrolysis were calculated in a stepwise procedure using a kineti …
Nicotinate esters were studied for their binding to, and hydrolysis by, human serum albumin. ...Only p-methoxyphenyl nicotinate …
Convenient Retinoid X Receptor Binding Assay Based on Fluorescence Change of the Antagonist NEt-C343.
Yukawa-Takamatsu K, Wang Y, Watanabe M, Takamura Y, Fujihara M, Nakamura-Nakayama M, Yamada S, Kikuzawa S, Makishima M, Kawasaki M, Ito S, Nakano S, Kakuta H. Yukawa-Takamatsu K, et al. J Med Chem. 2021 Jan 14;64(1):861-870. doi: 10.1021/acs.jmedchem.0c01883. Epub 2020 Dec 30. J Med Chem. 2021. PMID: 33378197
Here, we present a new fluorescent RXR antagonist 6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(11-oxo-2,3,6,7-tetrahydro-1H,5H,11H-pyrano[2,3-f]pyrido[3,2,1-ij]quinoline-10-carboxamido)phenyl)amino]nicotinic acid (NEt-C343, 7), which emits strong fluorescence only when …
Here, we present a new fluorescent RXR antagonist 6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(11-oxo-2,3,6,7-tetrahydro-1H,5H,11H-pyrano …
Nimodipine: synthesis and metabolic pathway.
Meyer H, Wehinger E, Bossert F, Scherling D. Meyer H, et al. Arzneimittelforschung. 1983;33(1):106-12. doi: 10.1002/chin.198320206. Arzneimittelforschung. 1983. PMID: 6681961
Key step of the synthesis of the calcium antagonistic cerebral vasodilator (+/-) isopropyl-2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (Bay e 9736, nimodipine) (5) is the cyclizing Michael addition of 3 onto 4. ...
Key step of the synthesis of the calcium antagonistic cerebral vasodilator (+/-) isopropyl-2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4- …
102 results