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The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.
Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BT, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M. Zhang JG, et al. Among authors: kile bt. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2071-6. doi: 10.1073/pnas.96.5.2071. Proc Natl Acad Sci U S A. 1999. PMID: 10051596 Free PMC article.
High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production.
Heazlewood SY, Ahmad T, Cao B, Cao H, Domingues M, Sun X, Heazlewood CK, Li S, Williams B, Fulton M, White JF, Nebl T, Nefzger CM, Polo JM, Kile BT, Kraus F, Ryan MT, Sun YB, Choong PFM, Ellis SL, Anko ML, Nilsson SK. Heazlewood SY, et al. Among authors: kile bt. Nat Commun. 2023 Apr 13;14(1):2099. doi: 10.1038/s41467-023-37780-7. Nat Commun. 2023. PMID: 37055407 Free PMC article.
Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction.
Alexander WS, Starr R, Metcalf D, Nicholson SE, Farley A, Elefanty AG, Brysha M, Kile BT, Richardson R, Baca M, Zhang JG, Willson TA, Viney EM, Sprigg NS, Rakar S, Corbin J, Mifsud S, DiRago L, Cary D, Nicola NA, Hilton DJ. Alexander WS, et al. Among authors: kile bt. J Leukoc Biol. 1999 Oct;66(4):588-92. doi: 10.1002/jlb.66.4.588. J Leukoc Biol. 1999. PMID: 10534114 Review.
Negative regulators of cytokine signaling.
Kile BT, Nicola NA, Alexander WS. Kile BT, et al. Int J Hematol. 2001 Apr;73(3):292-8. doi: 10.1007/BF02981953. Int J Hematol. 2001. PMID: 11345194 Review.
Functional analysis of Asb-1 using genetic modification in mice.
Kile BT, Metcalf D, Mifsud S, DiRago L, Nicola NA, Hilton DJ, Alexander WS. Kile BT, et al. Mol Cell Biol. 2001 Sep;21(18):6189-97. doi: 10.1128/MCB.21.18.6189-6197.2001. Mol Cell Biol. 2001. PMID: 11509662 Free PMC article.
The suppressors of cytokine signalling (SOCS).
Kile BT, Alexander WS. Kile BT, et al. Cell Mol Life Sci. 2001 Oct;58(11):1627-35. doi: 10.1007/PL00000801. Cell Mol Life Sci. 2001. PMID: 11706989 Review.
The SOCS box: a tale of destruction and degradation.
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ. Kile BT, et al. Trends Biochem Sci. 2002 May;27(5):235-41. doi: 10.1016/s0968-0004(02)02085-6. Trends Biochem Sci. 2002. PMID: 12076535 Review.
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene.
Alexander WS, Viney EM, Zhang JG, Metcalf D, Kauppi M, Hyland CD, Carpinelli MR, Stevenson W, Croker BA, Hilton AA, Ellis S, Selan C, Nandurkar HH, Goodnow CC, Kile BT, Nicola NA, Roberts AW, Hilton DJ. Alexander WS, et al. Among authors: kile bt. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16442-7. doi: 10.1073/pnas.0607872103. Epub 2006 Oct 24. Proc Natl Acad Sci U S A. 2006. PMID: 17062753 Free PMC article.
149 results