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Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells.
Bodogai M, O'Connell J, Kim K, Kim Y, Moritoh K, Chen C, Gusev F, Vaughan K, Shulzhenko N, Mattison JA, Lee-Chang C, Chen W, Carlson O, Becker KG, Gurung M, Morgun A, White J, Meade T, Perdue K, Mack M, Ferrucci L, Trinchieri G, de Cabo R, Rogaev E, Egan J, Wu J, Biragyn A. Bodogai M, et al. Among authors: kim y, kim k. Sci Transl Med. 2018 Nov 14;10(467):eaat4271. doi: 10.1126/scitranslmed.aat4271. Sci Transl Med. 2018. PMID: 30429354 Free PMC article.
Muscle cannabinoid 1 receptor regulates Il-6 and myostatin expression, governing physical performance and whole-body metabolism.
González-Mariscal I, Montoro RA, O'Connell JF, Kim Y, Gonzalez-Freire M, Liu QR, Alfaras I, Carlson OD, Lehrmann E, Zhang Y, Becker KG, Hardivillé S, Ghosh P, Egan JM. González-Mariscal I, et al. Among authors: kim y. FASEB J. 2019 May;33(5):5850-5863. doi: 10.1096/fj.201801145R. Epub 2019 Feb 6. FASEB J. 2019. PMID: 30726112 Free PMC article.
These results collectively show that CB1R in muscle is sufficient to regulate whole-body metabolism and physical performance and is a novel target for the treatment of sarcopenic obesity. -Gonzalez-Mariscal, I., Montoro, R. A., O'Connell, J. F., Kim, Y., Gonzalez-Fr …
These results collectively show that CB1R in muscle is sufficient to regulate whole-body metabolism and physical performance and is a novel …
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