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Collagen of chronically inflamed skin is over-modified and upregulates secretion of matrix metalloproteinase 2 and matrix-degrading enzymes by endothelial cells and fibroblasts.
Hirota A, Ebihara T, Kusubata M, Kobayashi M, Kobayashi K, Kuwaba K, Tanaka K, Kiriyama T, Irie S, Koyama Y. Hirota A, et al. Among authors: kusubata m. J Invest Dermatol. 2003 Dec;121(6):1317-25. doi: 10.1111/j.1523-1747.2003.12637.x. J Invest Dermatol. 2003. PMID: 14675176 Free article.
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