Leadlay PF - Search Results

1

Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions.

Olano C, Wilkinson B, Sánchez C, Moss SJ, Sheridan R, Math V, Weston AJ, Braña AF, Martin CJ, Oliynyk M, Méndez C, Leadlay PF, Salas JA. Olano C, et al. Among authors: leadlay pf. Chem Biol. 2004 Jan;11(1):87-97. doi: 10.1016/j.chembiol.2003.12.018. Chem Biol. 2004. PMID: 15112998 Free article.

2

Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase.

Olano C, Wilkinson B, Moss SJ, Braña AF, Méndez C, Leadlay PF, Salas JA. Olano C, et al. Among authors: leadlay pf. Chem Commun (Camb). 2003 Nov 21;(22):2780-2. doi: 10.1039/b310648a. Chem Commun (Camb). 2003. PMID: 14651102

3

Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation.

Olano C, Moss SJ, Braña AF, Sheridan RM, Math V, Weston AJ, Méndez C, Leadlay PF, Wilkinson B, Salas JA. Olano C, et al. Among authors: leadlay pf. Mol Microbiol. 2004 Jun;52(6):1745-56. doi: 10.1111/j.1365-2958.2004.04090.x. Mol Microbiol. 2004. PMID: 15186422 Free article.

4

Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues.

Moss SJ, Carletti I, Olano C, Sheridan RM, Ward M, Math V, Nur-E-Alam M, Braña AF, Zhang MQ, Leadlay PF, Méndez C, Salas JA, Wilkinson B. Moss SJ, et al. Among authors: leadlay pf. Chem Commun (Camb). 2006 Jun 14;(22):2341-3. doi: 10.1039/b602931k. Epub 2006 May 11. Chem Commun (Camb). 2006. PMID: 16733573

5

Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.

Wilkinson B, Gregory MA, Moss SJ, Carletti I, Sheridan RM, Kaja A, Ward M, Olano C, Mendez C, Salas JA, Leadlay PF, vanGinckel R, Zhang MQ. Wilkinson B, et al. Among authors: leadlay pf. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5814-7. doi: 10.1016/j.bmcl.2006.08.073. Epub 2006 Sep 8. Bioorg Med Chem Lett. 2006. PMID: 16962775

6

Skipping in a hybrid polyketide synthase. Evidence for ACP-to-ACP chain transfer.

Thomas I, Martin CJ, Wilkinson CJ, Staunton J, Leadlay PF. Thomas I, et al. Among authors: leadlay pf. Chem Biol. 2002 Jul;9(7):781-7. doi: 10.1016/s1074-5521(02)00164-3. Chem Biol. 2002. PMID: 12144921

7

Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272.

Gaisser S, Kellenberger L, Kaja AL, Weston AJ, Lill RE, Wirtz G, Kendrew SG, Low L, Sheridan RM, Wilkinson B, Galloway IS, Stutzman-Engwall K, McArthur HA, Staunton J, Leadlay PF. Gaisser S, et al. Among authors: leadlay pf. Org Biomol Chem. 2003 Aug 21;1(16):2840-7. doi: 10.1039/b304022d. Org Biomol Chem. 2003. PMID: 12968333

8

Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthase.

Martin CJ, Timoney MC, Sheridan RM, Kendrew SG, Wilkinson B, Staunton JC, Leadlay PF. Martin CJ, et al. Among authors: leadlay pf. Org Biomol Chem. 2003 Dec 7;1(23):4144-7. doi: 10.1039/b310740j. Epub 2003 Oct 29. Org Biomol Chem. 2003. PMID: 14685317

9

Rapamycin biosynthesis: Elucidation of gene product function.

Gregory MA, Hong H, Lill RE, Gaisser S, Petkovic H, Low L, Sheehan LS, Carletti I, Ready SJ, Ward MJ, Kaja AL, Weston AJ, Challis IR, Leadlay PF, Martin CJ, Wilkinson B, Sheridan RM. Gregory MA, et al. Among authors: leadlay pf. Org Biomol Chem. 2006 Oct 7;4(19):3565-8. doi: 10.1039/b608813a. Epub 2006 Aug 22. Org Biomol Chem. 2006. PMID: 16990929

10

A hybrid modular polyketide synthase obtained by domain swapping.

Oliynyk M, Brown MJ, Cortés J, Staunton J, Leadlay PF. Oliynyk M, et al. Among authors: leadlay pf. Chem Biol. 1996 Oct;3(10):833-9. doi: 10.1016/s1074-5521(96)90069-1. Chem Biol. 1996. PMID: 8939702

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