Leadlay PF - Search Results

1

Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones.

Pidot SJ, Hong H, Seemann T, Porter JL, Yip MJ, Men A, Johnson M, Wilson P, Davies JK, Leadlay PF, Stinear TP. Pidot SJ, et al. Among authors: leadlay pf. BMC Genomics. 2008 Oct 7;9:462. doi: 10.1186/1471-2164-9-462. BMC Genomics. 2008. PMID: 18840298 Free PMC article.

2

Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans.

Hong H, Gates PJ, Staunton J, Stinear T, Cole ST, Leadlay PF, Spencer JB. Hong H, et al. Among authors: leadlay pf. Chem Commun (Camb). 2003 Nov 21;(22):2822-3. doi: 10.1039/b308163j. Chem Commun (Camb). 2003. PMID: 14651122

3

Identification of a phosphopantetheinyl transferase for erythromycin biosynthesis in Saccharopolyspora erythraea.

Weissman KJ, Hong H, Oliynyk M, Siskos AP, Leadlay PF. Weissman KJ, et al. Among authors: leadlay pf. Chembiochem. 2004 Jan 3;5(1):116-25. doi: 10.1002/cbic.200300775. Chembiochem. 2004. PMID: 14695521

4

Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.

Stinear TP, Mve-Obiang A, Small PL, Frigui W, Pryor MJ, Brosch R, Jenkin GA, Johnson PD, Davies JK, Lee RE, Adusumilli S, Garnier T, Haydock SF, Leadlay PF, Cole ST. Stinear TP, et al. Among authors: leadlay pf. Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1345-9. doi: 10.1073/pnas.0305877101. Epub 2004 Jan 21. Proc Natl Acad Sci U S A. 2004. PMID: 14736915 Free PMC article.

5

Engineered biosynthesis of phenyl-substituted polyketides.

Garcia-Bernardo J, Xiang L, Hong H, Moore BS, Leadlay PF. Garcia-Bernardo J, et al. Among authors: leadlay pf. Chembiochem. 2004 Aug 6;5(8):1129-31. doi: 10.1002/cbic.200400007. Chembiochem. 2004. PMID: 15300838 No abstract available.

6

Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans.

Stinear TP, Hong H, Frigui W, Pryor MJ, Brosch R, Garnier T, Leadlay PF, Cole ST. Stinear TP, et al. Among authors: leadlay pf. J Bacteriol. 2005 Mar;187(5):1668-76. doi: 10.1128/JB.187.5.1668-1676.2005. J Bacteriol. 2005. PMID: 15716437 Free PMC article.

7

A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase.

Hong H, Spencer JB, Porter JL, Leadlay PF, Stinear T. Hong H, et al. Among authors: leadlay pf. Chembiochem. 2005 Apr;6(4):643-8. doi: 10.1002/cbic.200400339. Chembiochem. 2005. PMID: 15750996 No abstract available.

8

Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion-trap mass spectrometry.

Hong H, Appleyard AN, Siskos AP, Garcia-Bernardo J, Staunton J, Leadlay PF. Hong H, et al. Among authors: leadlay pf. FEBS J. 2005 May;272(10):2373-87. doi: 10.1111/j.1742-4658.2005.04615.x. FEBS J. 2005. PMID: 15885088 Free article.

9

Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry.

Hong H, Stinear T, Skelton P, Spencer JB, Leadlay PF. Hong H, et al. Among authors: leadlay pf. Chem Commun (Camb). 2005 Sep 14;(34):4306-8. doi: 10.1039/b506835e. Epub 2005 Aug 5. Chem Commun (Camb). 2005. PMID: 16113730

10

Rapamycin biosynthesis: Elucidation of gene product function.

Gregory MA, Hong H, Lill RE, Gaisser S, Petkovic H, Low L, Sheehan LS, Carletti I, Ready SJ, Ward MJ, Kaja AL, Weston AJ, Challis IR, Leadlay PF, Martin CJ, Wilkinson B, Sheridan RM. Gregory MA, et al. Among authors: leadlay pf. Org Biomol Chem. 2006 Oct 7;4(19):3565-8. doi: 10.1039/b608813a. Epub 2006 Aug 22. Org Biomol Chem. 2006. PMID: 16990929

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