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Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model.
Rogers TF, Zhao F, Huang D, Beutler N, Burns A, He WT, Limbo O, Smith C, Song G, Woehl J, Yang L, Abbott RK, Callaghan S, Garcia E, Hurtado J, Parren M, Peng L, Ramirez S, Ricketts J, Ricciardi MJ, Rawlings SA, Wu NC, Yuan M, Smith DM, Nemazee D, Teijaro JR, Voss JE, Wilson IA, Andrabi R, Briney B, Landais E, Sok D, Jardine JG, Burton DR. Rogers TF, et al. Among authors: limbo o. Science. 2020 Aug 21;369(6506):956-963. doi: 10.1126/science.abc7520. Epub 2020 Jun 15. Science. 2020. PMID: 32540903 Free PMC article.
Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model.
Rogers TF, Zhao F, Huang D, Beutler N, Burns A, He WT, Limbo O, Smith C, Song G, Woehl J, Yang L, Abbott RK, Callaghan S, Garcia E, Hurtado J, Parren M, Peng L, Ricketts J, Ricciardi MJ, Rawlings SA, Smith DM, Nemazee D, Teijaro JR, Voss JE, Andrabi R, Briney B, Landais E, Sok D, Jardine JG, Burton DR. Rogers TF, et al. Among authors: limbo o. bioRxiv [Preprint]. 2020 May 15:2020.05.11.088674. doi: 10.1101/2020.05.11.088674. bioRxiv. 2020. PMID: 32511387 Free PMC article. Updated. Preprint.
A Rapid Assay for SARS-CoV-2 Neutralizing Antibodies That Is Insensitive to Antiretroviral Drugs.
Huang D, Tran JT, Peng L, Yang L, Suhandynata RT, Hoffman MA, Zhao F, Song G, He WT, Limbo O, Callaghan S, Landais E, Andrabi R, Sok D, Jardine JG, Burton DR, Voss JE, Fitzgerald RL, Nemazee D. Huang D, et al. Among authors: limbo o. J Immunol. 2021 Jul 1;207(1):344-351. doi: 10.4049/jimmunol.2100155. Epub 2021 Jun 28. J Immunol. 2021. PMID: 34183368 Free PMC article.
Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease.
Zhou P, Song G, He WT, Beutler N, Tse LV, Martinez DR, Schäfer A, Anzanello F, Yong P, Peng L, Dueker K, Musharrafieh R, Callaghan S, Capozzola T, Yuan M, Liu H, Limbo O, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Jardine JG, Wilson IA, Safonova Y, Rogers TF, Baric RS, Gralinski LE, Burton DR, Andrabi R. Zhou P, et al. Among authors: limbo o. bioRxiv [Preprint]. 2022 Mar 7:2022.03.04.479488. doi: 10.1101/2022.03.04.479488. bioRxiv. 2022. PMID: 35291291 Free PMC article. Updated. Preprint.
Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways.
Zhao F, Keating C, Ozorowski G, Shaabani N, Francino-Urdaniz IM, Barman S, Limbo O, Burns A, Zhou P, Ricciardi MJ, Woehl J, Tran Q, Turner HL, Peng L, Huang D, Nemazee D, Andrabi R, Sok D, Teijaro JR, Whitehead TA, Ward AB, Burton DR, Jardine JG. Zhao F, et al. Among authors: limbo o. iScience. 2022 Sep 16;25(9):104914. doi: 10.1016/j.isci.2022.104914. Epub 2022 Aug 11. iScience. 2022. PMID: 35971553 Free PMC article.
Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus.
Zhao F, Berndsen ZT, Pedreño-Lopez N, Burns A, Allen JD, Barman S, Lee WH, Chakraborty S, Gnanakaran S, Sewall LM, Ozorowski G, Limbo O, Song G, Yong P, Callaghan S, Coppola J, Weisgrau KL, Lifson JD, Nedellec R, Voigt TB, Laurino F, Louw J, Rosen BC, Ricciardi M, Crispin M, Desrosiers RC, Rakasz EG, Watkins DI, Andrabi R, Ward AB, Burton DR, Sok D. Zhao F, et al. Among authors: limbo o. Nat Commun. 2022 Sep 6;13(1):5236. doi: 10.1038/s41467-022-32783-2. Nat Commun. 2022. PMID: 36068229 Free PMC article.
Fully synthetic platform to rapidly generate tetravalent bispecific nanobody-based immunoglobulins.
Misson Mindrebo L, Liu H, Ozorowski G, Tran Q, Woehl J, Khalek I, Smith JM, Barman S, Zhao F, Keating C, Limbo O, Verma M, Liu J, Stanfield RL, Zhu X, Turner HL, Sok D, Huang PS, Burton DR, Ward AB, Wilson IA, Jardine JG. Misson Mindrebo L, et al. Among authors: limbo o. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2216612120. doi: 10.1073/pnas.2216612120. Epub 2023 Jun 5. Proc Natl Acad Sci U S A. 2023. PMID: 37276407 Free PMC article.
Broadening a SARS-CoV-1-neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution.
Zhao F, Yuan M, Keating C, Shaabani N, Limbo O, Joyce C, Woehl J, Barman S, Burns A, Tran Q, Zhu X, Ricciardi M, Peng L, Smith J, Huang D, Briney B, Sok D, Nemazee D, Teijaro JR, Wilson IA, Burton DR, Jardine JG. Zhao F, et al. Among authors: limbo o. Sci Signal. 2023 Aug 15;16(798):eabk3516. doi: 10.1126/scisignal.abk3516. Epub 2023 Aug 15. Sci Signal. 2023. PMID: 37582161
Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins.
Khalek IS, Senji Laxme RR, Nguyen YTK, Khochare S, Patel RN, Woehl J, Smith JM, Saye-Francisco K, Kim Y, Misson Mindrebo L, Tran Q, Kędzior M, Boré E, Limbo O, Verma M, Stanfield RL, Menzies SK, Ainsworth S, Harrison RA, Burton DR, Sok D, Wilson IA, Casewell NR, Sunagar K, Jardine JG. Khalek IS, et al. Among authors: limbo o. Sci Transl Med. 2024 Feb 21;16(735):eadk1867. doi: 10.1126/scitranslmed.adk1867. Epub 2024 Feb 21. Sci Transl Med. 2024. PMID: 38381847
34 results