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Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial.
Lorentz CU, Verbout NG, Wallisch M, Hagen MW, Shatzel JJ, Olson SR, Puy C, Hinds MT, McCarty OJT, Gailani D, Gruber A, Tucker EI. Lorentz CU, et al. Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):799-809. doi: 10.1161/ATVBAHA.118.312328. Arterioscler Thromb Vasc Biol. 2019. PMID: 30700130 Free PMC article. Clinical Trial.
The protein C activator AB002 rapidly interrupts thrombus development in baboons.
Tucker EI, Verbout NG, Markway BD, Wallisch M, Lorentz CU, Hinds MT, Shatzel JJ, Pelc LA, Wood DC, McCarty OJT, Di Cera E, Gruber A. Tucker EI, et al. Among authors: lorentz cu. Blood. 2020 Feb 27;135(9):689-699. doi: 10.1182/blood.2019002771. Blood. 2020. PMID: 31977000 Free PMC article. Clinical Trial.
Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates.
Wallisch M, Lorentz CU, Lakshmanan HHS, Johnson J, Carris MR, Puy C, Gailani D, Hinds MT, McCarty OJT, Gruber A, Tucker EI. Wallisch M, et al. Among authors: lorentz cu. Res Pract Thromb Haemost. 2020 Feb 11;4(2):205-216. doi: 10.1002/rth2.12309. eCollection 2020 Feb. Res Pract Thromb Haemost. 2020. PMID: 32110750 Free PMC article.
Pharmacological targeting of coagulation factor XI mitigates the development of experimental atherosclerosis in low-density lipoprotein receptor-deficient mice.
Ngo ATP, Jordan KR, Mueller PA, Hagen MW, Reitsma SE, Puy C, Revenko AS, Lorentz CU, Tucker EI, Cheng Q, Hinds MT, Fazio S, Monia BP, Gailani D, Gruber A, Tavori H, McCarty OJT. Ngo ATP, et al. Among authors: lorentz cu. J Thromb Haemost. 2021 Apr;19(4):1001-1017. doi: 10.1111/jth.15236. Epub 2021 Feb 10. J Thromb Haemost. 2021. PMID: 33421301 Free PMC article.
Role of platelets in regulating activated coagulation factor XI activity.
Reitsma SE, Pang J, Raghunathan V, Shatzel JJ, Lorentz CU, Tucker EI, Gruber A, Gailani D, McCarty OJT, Puy C. Reitsma SE, et al. Among authors: lorentz cu. Am J Physiol Cell Physiol. 2021 Mar 1;320(3):C365-C374. doi: 10.1152/ajpcell.00056.2020. Epub 2021 Jan 20. Am J Physiol Cell Physiol. 2021. PMID: 33471623 Free PMC article.
Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus.
Silasi R, Keshari RS, Regmi G, Lupu C, Georgescu C, Simmons JH, Wallisch M, Kohs TCL, Shatzel JJ, Olson SR, Lorentz CU, Puy C, Tucker EI, Gailani D, Strickland S, Gruber A, McCarty OJT, Lupu F. Silasi R, et al. Among authors: lorentz cu. Blood. 2021 Jul 15;138(2):178-189. doi: 10.1182/blood.2020009345. Blood. 2021. PMID: 33598692 Free PMC article.
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