Lucas X - Search Results

1

4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).

Hügle M, Lucas X, Weitzel G, Ostrovskyi D, Breit B, Gerhardt S, Einsle O, Günther S, Wohlwend D. Hügle M, et al. Among authors: lucas x. J Med Chem. 2016 Feb 25;59(4):1518-30. doi: 10.1021/acs.jmedchem.5b01267. Epub 2016 Jan 14. J Med Chem. 2016. PMID: 26731611

2

4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines.

Hügle M, Regenass P, Warstat R, Hau M, Schmidtkunz K, Lucas X, Wohlwend D, Einsle O, Jung M, Breit B, Günther S. Hügle M, et al. Among authors: lucas x. J Med Chem. 2020 Dec 24;63(24):15603-15620. doi: 10.1021/acs.jmedchem.0c00478. Epub 2020 Dec 4. J Med Chem. 2020. PMID: 33275431

3

Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.

Hügle M, Lucas X, Ostrovskyi D, Regenass P, Gerhardt S, Einsle O, Hau M, Jung M, Breit B, Günther S, Wohlwend D. Hügle M, et al. Among authors: lucas x. Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12476-12480. doi: 10.1002/anie.201705516. Epub 2017 Sep 7. Angew Chem Int Ed Engl. 2017. PMID: 28766825

4

Discovery of the inhibitory effect of a phosphatidylinositol derivative on P-glycoprotein by virtual screening followed by in vitro cellular studies.

Lucas X, Simon S, Schubert R, Günther S. Lucas X, et al. PLoS One. 2013 Apr 9;8(4):e60679. doi: 10.1371/journal.pone.0060679. Print 2013. PLoS One. 2013. PMID: 23593281 Free PMC article.

5

4-Acyl pyrroles: mimicking acetylated lysines in histone code reading.

Lucas X, Wohlwend D, Hügle M, Schmidtkunz K, Gerhardt S, Schüle R, Jung M, Einsle O, Günther S. Lucas X, et al. Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14055-9. doi: 10.1002/anie.201307652. Epub 2013 Nov 24. Angew Chem Int Ed Engl. 2013. PMID: 24272870 No abstract available.

6

Targeting the BET family for the treatment of leukemia.

Lucas X, Günther S. Lucas X, et al. Epigenomics. 2014 Apr;6(2):153-5. doi: 10.2217/epi.14.5. Epigenomics. 2014. PMID: 24811781 Free article. No abstract available.

7

Using chiral molecules as an approach to address low-druggability recognition sites.

Lucas X, Günther S. Lucas X, et al. J Comput Chem. 2014 Nov 5;35(29):2114-21. doi: 10.1002/jcc.23726. Epub 2014 Sep 16. J Comput Chem. 2014. PMID: 25223950

8

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes.

Hügle M, Lucas X, Weitzel G, Ostrovskyi D, Breit B, Gerhardt S, Schmidtkunz K, Jung M, Schüle R, Einsle O, Günther S, Wohlwend D. Hügle M, et al. Among authors: lucas x. Data Brief. 2016 Apr 11;7:1370-4. doi: 10.1016/j.dib.2016.04.009. eCollection 2016 Jun. Data Brief. 2016. PMID: 27158652 Free PMC article.

9

The purchasable chemical space: a detailed picture.

Lucas X, Grüning BA, Bleher S, Günther S. Lucas X, et al. J Chem Inf Model. 2015 May 26;55(5):915-24. doi: 10.1021/acs.jcim.5b00116. Epub 2015 Apr 30. J Chem Inf Model. 2015. PMID: 25894297

10

Target Fishing by Cross-Docking to Explain Polypharmacological Effects.

Patel H, Lucas X, Bendik I, Günther S, Merfort I. Patel H, et al. Among authors: lucas x. ChemMedChem. 2015 Jul;10(7):1209-17. doi: 10.1002/cmdc.201500123. Epub 2015 Jun 1. ChemMedChem. 2015. PMID: 26033840

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