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Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.
Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay PF, Wilkinson B. Andexer JN, et al. Among authors: moss sj. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4776-81. doi: 10.1073/pnas.1015773108. Epub 2011 Mar 7. Proc Natl Acad Sci U S A. 2011. PMID: 21383123 Free PMC article.
Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms.
Woolard J, Vousden W, Moss SJ, Krishnakumar A, Gammons MV, Nowak DG, Dixon N, Micklefield J, Spannhoff A, Bedford MT, Gregory MA, Martin CJ, Leadlay PF, Zhang MQ, Harper SJ, Bates DO, Wilkinson B. Woolard J, et al. Among authors: moss sj. Chem Sci. 2011 Feb 1;2011(2):273-278. doi: 10.1039/C0SC00297F. Chem Sci. 2011. PMID: 22822423 Free PMC article.
391 results