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MTMR7 suppresses the phenotypic switching of vascular smooth muscle cell and vascular intimal hyperplasia after injury via regulating p62/mTORC1-mediated glucose metabolism.
Sun X, Yang Y, Zhao W, Wang M, Chen Y, Wang J, Yang D, Yang Y. Sun X, et al. Atherosclerosis. 2024 Mar;390:117470. doi: 10.1016/j.atherosclerosis.2024.117470. Epub 2024 Feb 1. Atherosclerosis. 2024. PMID: 38342025
METHODS AND RESULTS: MTMR7 expression was significantly downregulated in injured arteries. Compared to wild type (WT) mice, Mtmr7-transgenic (Mtmr7-Tg) mice showed reduced intima/media ratio, decreased percentage of Ki-67-positive cells within neointima, and …
METHODS AND RESULTS: MTMR7 expression was significantly downregulated in injured arteries. Compared to wild type (WT) mice, Mtmr7 …
Genetics of prion diseases.
Lloyd SE, Mead S, Collinge J. Lloyd SE, et al. Curr Opin Genet Dev. 2013 Jun;23(3):345-51. doi: 10.1016/j.gde.2013.02.012. Epub 2013 Mar 19. Curr Opin Genet Dev. 2013. PMID: 23518043 Free PMC article. Review.
Two recent genome wide association studies in human have identified four new loci of interest: ZBTB38-RASA2 in UK CJD cases and MTMR7 and NPAS2 in variant CJD. Complementary studies in mouse have used complex crosses to identify new modifiers such as Cpne8 and provided sup …
Two recent genome wide association studies in human have identified four new loci of interest: ZBTB38-RASA2 in UK CJD cases and MTMR7 …
Myotubularin-related protein 7 activates peroxisome proliferator-activated receptor-gamma.
Weidner P, Söhn M, Schroeder T, Helm L, Hauber V, Gutting T, Betge J, Röcken C, Rohrbacher FN, Pattabiraman VR, Bode JW, Seger R, Saar D, Nunes-Alves A, Wade RC, Ebert MPA, Burgermeister E. Weidner P, et al. Oncogenesis. 2020 Jun 10;9(6):59. doi: 10.1038/s41389-020-0238-8. Oncogenesis. 2020. PMID: 32522977 Free PMC article.
Phosphoinositide phosphatase Myotubularin-Related-Protein-7 (MTMR7) was identified as cytosolic interaction partner of PPARgamma. ...MTMR7-CC peptides mimicked PPARgamma-activation in vitro and in vivo due to LXXLL motifs in the CC domain. ...
Phosphoinositide phosphatase Myotubularin-Related-Protein-7 (MTMR7) was identified as cytosolic interaction partner of PPARgamma. ... …
Myotubularin-related protein 7 inhibits insulin signaling in colorectal cancer.
Weidner P, Söhn M, Gutting T, Friedrich T, Gaiser T, Magdeburg J, Kienle P, Ruh H, Hopf C, Behrens HM, Röcken C, Hanoch T, Seger R, Ebert MP, Burgermeister E. Weidner P, et al. Oncotarget. 2016 Aug 2;7(31):50490-50506. doi: 10.18632/oncotarget.10466. Oncotarget. 2016. PMID: 27409167 Free PMC article.
The presence of MTMR7 in the stroma correlated with poor prognosis, whereas MTMR7 expression in the tumor was not predictive for patients' survival. Insulin reduced MTMR7 protein levels in human CRC cell lines, and CRC patients with type 2 diabetes mellitus ( …
The presence of MTMR7 in the stroma correlated with poor prognosis, whereas MTMR7 expression in the tumor was not predictive f …
Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
Weidner P, Saar D, Söhn M, Schroeder T, Yu Y, Zöllner FG, Ponelies N, Zhou X, Zwicky A, Rohrbacher FN, Pattabiraman VR, Tanriver M, Bauer A, Ahmed H, Ametamey SM, Riffel P, Seger R, Bode JW, Wade RC, Ebert MPA, Kragelund BB, Burgermeister E. Weidner P, et al. Cancer Lett. 2024 Apr 28;588:216783. doi: 10.1016/j.canlet.2024.216783. Epub 2024 Mar 9. Cancer Lett. 2024. PMID: 38462034 Free article.
Using cell and structural biology combined with animal studies, we show that MTMR7 binds and inhibits RAS at cellular membranes. Overexpression of MTMR7 reduced RAS GTPase activities and protein levels, ERK1/2 phosphorylation, c-FOS transcription and cancer cell pro …
Using cell and structural biology combined with animal studies, we show that MTMR7 binds and inhibits RAS at cellular membranes. Over …
Expression of the EGFR-RAS Inhibitory Proteins DOK1 and MTMR7 and its Significance in Colorectal Adenoma and Adenoma Recurrence.
Gutting T, Merkel A, Fink DJ, Hetjens S, Weidner P, Yu Y, Kähler G, Ebert MP, Gaiser T, Burgermeister E, Belle S. Gutting T, et al. J Gastrointestin Liver Dis. 2021 Dec 21;30(4):446-455. doi: 10.15403/jgld-3681. J Gastrointestin Liver Dis. 2021. PMID: 34941983 Free article.
We aimed to characterize the expression of docking protein 1 (DOK1) and myotubularin-related protein 7 (MTMR7), which share inhibiting functions on EGFR-RAS-signalling, a major oncogenic driver in CRC, and their association with clinical variables and adenoma recurrence. . …
We aimed to characterize the expression of docking protein 1 (DOK1) and myotubularin-related protein 7 (MTMR7), which share inhibitin …
Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk.
Sanchez-Juan P, Bishop MT, Aulchenko YS, Brandel JP, Rivadeneira F, Struchalin M, Lambert JC, Amouyel P, Combarros O, Sainz J, Carracedo A, Uitterlinden AG, Hofman A, Zerr I, Kretzschmar HA, Laplanche JL, Knight RS, Will RG, van Duijn CM. Sanchez-Juan P, et al. Neurobiol Aging. 2012 Jul;33(7):1487.e21-8. doi: 10.1016/j.neurobiolaging.2011.10.011. Epub 2011 Dec 2. Neurobiol Aging. 2012. PMID: 22137330
Rs4921542 (p = 1.6 10(-8)) is an intronic variant in the myotubularin related protein 7 gene (MTMR7), which is specifically expressed in the central nervous system (CNS) and dephosphorylates phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. ...
Rs4921542 (p = 1.6 10(-8)) is an intronic variant in the myotubularin related protein 7 gene (MTMR7), which is specifically expressed …
Silencing myotubularin related protein 7 enhances proliferation and early differentiation of C2C12 myoblast.
Yuan Z, Chen Y, Zhang X, Zhou X, Li M, Chen H, Wu M, Zhang Y, Mo D. Yuan Z, et al. Biochem Biophys Res Commun. 2017 Mar 11;484(3):592-597. doi: 10.1016/j.bbrc.2017.01.143. Epub 2017 Jan 31. Biochem Biophys Res Commun. 2017. PMID: 28153733
MTMR7 was increased during myoblast differentiation and exhibited high expression level at primary fibers formation stages in pigs. This suggests that MTMR7 may be involved in myogenesis. In our study, we investigated the roles of MTMR7 on proliferation and d …
MTMR7 was increased during myoblast differentiation and exhibited high expression level at primary fibers formation stages in pigs. T …
Myotubularin related protein 7 is essential for the spermatogonial stem cell homeostasis via PI3K/AKT signaling.
Zhao D, Shen C, Gao T, Li H, Guo Y, Li F, Liu C, Liu Y, Chen X, Zhang X, Wu Y, Yu Y, Lin M, Yuan Y, Chen X, Huang X, Yang S, Yu J, Zhang J, Zheng B. Zhao D, et al. Cell Cycle. 2019 Oct;18(20):2800-2813. doi: 10.1080/15384101.2019.1661174. Epub 2019 Sep 3. Cell Cycle. 2019. PMID: 31478454 Free PMC article.
We have previously identified MTMR7 in the proteomic profile of mouse spermatogonial stem cell (SSC) maturation and differentiation, implying that MTMR7 is associated with neonatal testicular development. In this study, to further explore the distribution and functi …
We have previously identified MTMR7 in the proteomic profile of mouse spermatogonial stem cell (SSC) maturation and differentiation, …
Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9.
Mochizuki Y, Majerus PW. Mochizuki Y, et al. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9768-73. doi: 10.1073/pnas.1333958100. Epub 2003 Jul 30. Proc Natl Acad Sci U S A. 2003. PMID: 12890864 Free PMC article.
An MTMR7-binding protein was found in an anti-MTMR7 immunoprecipitate from N1E-115 cells and identified as MTM-related protein 9 (MTMR9) by tandem mass spectrometry. The coiled-coil domain of MTMR9 was sufficient for binding to MTMR7. The binding of MTMR9 inc …
An MTMR7-binding protein was found in an anti-MTMR7 immunoprecipitate from N1E-115 cells and identified as MTM-related protein …
20 results