Ornstein PL - Search Results

1

Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes.

Wright RA, Arnold MB, Wheeler WJ, Ornstein PL, Schoepp DD. Wright RA, et al. Among authors: ornstein pl. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. doi: 10.1007/s002100000305. Naunyn Schmiedebergs Arch Pharmacol. 2000. PMID: 11138847

2

Synthesis and structure-activity relationship studies of novel 2-diarylethyl substituted (2-carboxycycloprop-1-yl)glycines as high-affinity group II metabotropic glutamate receptor ligands.

Sørensen US, Bleisch TJ, Kingston AE, Wright RA, Johnson BG, Schoepp DD, Ornstein PL. Sørensen US, et al. Among authors: ornstein pl. Bioorg Med Chem. 2003 Jan 17;11(2):197-205. doi: 10.1016/s0968-0896(02)00387-5. Bioorg Med Chem. 2003. PMID: 12470714

3

2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 1. Effects of alkyl, arylalkyl, and diarylalkyl substitution.

Ornstein PL, Bleisch TJ, Arnold MB, Wright RA, Johnson BG, Schoepp DD. Ornstein PL, et al. J Med Chem. 1998 Jan 29;41(3):346-57. doi: 10.1021/jm970497w. J Med Chem. 1998. PMID: 9464366

4

2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability.

Ornstein PL, Bleisch TJ, Arnold MB, Kennedy JH, Wright RA, Johnson BG, Tizzano JP, Helton DR, Kallman MJ, Schoepp DD, Hérin M. Ornstein PL, et al. J Med Chem. 1998 Jan 29;41(3):358-78. doi: 10.1021/jm970498o. J Med Chem. 1998. PMID: 9464367

5

LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors.

Kingston AE, Ornstein PL, Wright RA, Johnson BG, Mayne NG, Burnett JP, Belagaje R, Wu S, Schoepp DD. Kingston AE, et al. Among authors: ornstein pl. Neuropharmacology. 1998;37(1):1-12. doi: 10.1016/s0028-3908(97)00191-3. Neuropharmacology. 1998. PMID: 9680254

6

[3H]LY341495, a highly potent, selective and novel radioligand for labeling Group II metabotropic glutamate receptors.

Ornstein PL, Arnold MB, Bleisch TJ, Wright RA, Wheeler WJ, Schoepp DD. Ornstein PL, et al. Bioorg Med Chem Lett. 1998 Jul 21;8(14):1919-22. doi: 10.1016/s0960-894x(98)00329-1. Bioorg Med Chem Lett. 1998. PMID: 9873459

7

[3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells.

Johnson BG, Wright RA, Arnold MB, Wheeler WJ, Ornstein PL, Schoepp DD. Johnson BG, et al. Among authors: ornstein pl. Neuropharmacology. 1999 Oct;38(10):1519-29. doi: 10.1016/s0028-3908(99)00053-2. Neuropharmacology. 1999. PMID: 10530814

8

[3H]LY341495 binding to group II metabotropic glutamate receptors in rat brain.

Wright RA, Arnold MB, Wheeler WJ, Ornstein PL, Schoepp DD. Wright RA, et al. Among authors: ornstein pl. J Pharmacol Exp Ther. 2001 Aug;298(2):453-60. J Pharmacol Exp Ther. 2001. PMID: 11454905

9

Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo.

Weiss B, Alt A, Ogden AM, Gates M, Dieckman DK, Clemens-Smith A, Ho KH, Jarvie K, Rizkalla G, Wright RA, Calligaro DO, Schoepp D, Mattiuz EL, Stratford RE, Johnson B, Salhoff C, Katofiasc M, Phebus LA, Schenck K, Cohen M, Filla SA, Ornstein PL, Johnson KW, Bleakman D. Weiss B, et al. Among authors: ornstein pl. J Pharmacol Exp Ther. 2006 Aug;318(2):772-81. doi: 10.1124/jpet.106.101428. Epub 2006 May 11. J Pharmacol Exp Ther. 2006. PMID: 16690725

10

NMDA antagonist activity of (+/-)-(2SR,4RS)-4-(1H-tetrazol-5-ylmethyl)piperidine-2-carboxylic acid resides with the (-)-2R,4S-isomer.

Ornstein PL, Schoepp DD, Arnold MB, Jones ND, Deeter JB, Lodge D, Leander JD. Ornstein PL, et al. J Med Chem. 1992 Aug 21;35(17):3111-5. doi: 10.1021/jm00095a004. J Med Chem. 1992. PMID: 1387167

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