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Page 1
Autophagy maintains stemness by preventing senescence.
García-Prat L, Martínez-Vicente M, Perdiguero E, Ortet L, Rodríguez-Ubreva J, Rebollo E, Ruiz-Bonilla V, Gutarra S, Ballestar E, Serrano AL, Sandri M, Muñoz-Cánoves P. García-Prat L, et al. Among authors: ortet l. Nature. 2016 Jan 7;529(7584):37-42. doi: 10.1038/nature16187. Nature. 2016. PMID: 26738589
Geriatric muscle stem cells switch reversible quiescence into senescence.
Sousa-Victor P, Gutarra S, García-Prat L, Rodriguez-Ubreva J, Ortet L, Ruiz-Bonilla V, Jardí M, Ballestar E, González S, Serrano AL, Perdiguero E, Muñoz-Cánoves P. Sousa-Victor P, et al. Among authors: ortet l. Nature. 2014 Feb 20;506(7488):316-21. doi: 10.1038/nature13013. Epub 2014 Feb 12. Nature. 2014. PMID: 24522534
FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age.
García-Prat L, Perdiguero E, Alonso-Martín S, Dell'Orso S, Ravichandran S, Brooks SR, Juan AH, Campanario S, Jiang K, Hong X, Ortet L, Ruiz-Bonilla V, Flández M, Moiseeva V, Rebollo E, Jardí M, Sun HW, Musarò A, Sandri M, Del Sol A, Sartorelli V, Muñoz-Cánoves P. García-Prat L, et al. Among authors: ortet l. Nat Cell Biol. 2020 Nov;22(11):1307-1318. doi: 10.1038/s41556-020-00593-7. Epub 2020 Oct 26. Nat Cell Biol. 2020. PMID: 33106654
3-deazaadenosine (3DA) alleviates senescence to promote cellular fitness and cell therapy efficiency in mice.
Guerrero A, Innes AJ, Roux PF, Buisman SC, Jung J, Ortet L, Moiseeva V, Wagner V, Robinson L, Ausema A, Potapova A, Perdiguero E, Weersing E, Aarts M, Martin N, Wuestefeld T, Muñoz-Cánoves P, de Haan G, Bischof O, Gil J. Guerrero A, et al. Among authors: ortet l. Nat Aging. 2022 Sep;2:851-866. doi: 10.1038/s43587-022-00279-9. Epub 2022 Sep 13. Nat Aging. 2022. PMID: 36438588 Free PMC article.
Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration.
Moiseeva V, Cisneros A, Sica V, Deryagin O, Lai Y, Jung S, Andrés E, An J, Segalés J, Ortet L, Lukesova V, Volpe G, Benguria A, Dopazo A, Benitah SA, Urano Y, Del Sol A, Esteban MA, Ohkawa Y, Serrano AL, Perdiguero E, Muñoz-Cánoves P. Moiseeva V, et al. Among authors: ortet l. Nature. 2023 Jan;613(7942):169-178. doi: 10.1038/s41586-022-05535-x. Epub 2022 Dec 21. Nature. 2023. PMID: 36544018 Free PMC article.
Author Correction: Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration.
Moiseeva V, Cisneros A, Sica V, Deryagin O, Lai Y, Jung S, Andrés E, An J, Segalés J, Ortet L, Lukesova V, Volpe G, Benguria A, Dopazo A, Benitah SA, Urano Y, Del Sol A, Esteban MA, Ohkawa Y, Serrano AL, Perdiguero E, Muñoz-Cánoves P. Moiseeva V, et al. Among authors: ortet l. Nature. 2023 Feb;614(7949):E45. doi: 10.1038/s41586-023-05765-7. Nature. 2023. PMID: 36747036 Free PMC article. No abstract available.