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PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum.
Alhalabi KT, Stichel D, Sievers P, Peterziel H, Sommerkamp AC, Sturm D, Wittmann A, Sill M, Jäger N, Beck P, Pajtler KW, Snuderl M, Jour G, Delorenzo M, Martin AM, Levy A, Dalvi N, Hansford JR, Gottardo NG, Uro-Coste E, Maurage CA, Godfraind C, Vandenbos F, Pietsch T, Kramm C, Filippidou M, Kattamis A, Jones C, Øra I, Mikkelsen TS, Zapotocky M, Sumerauer D, Scheie D, McCabe M, Wesseling P, Tops BBJ, Kranendonk MEG, Karajannis MA, Bouvier N, Papaemmanuil E, Dohmen H, Acker T, von Hoff K, Schmid S, Miele E, Filipski K, Kitanovski L, Krskova L, Gojo J, Haberler C, Alvaro F, Ecker J, Selt F, Milde T, Witt O, Oehme I, Kool M, von Deimling A, Korshunov A, Pfister SM, Sahm F, Jones DTW. Alhalabi KT, et al. Acta Neuropathol. 2021 Nov;142(5):841-857. doi: 10.1007/s00401-021-02354-8. Epub 2021 Aug 21. Acta Neuropathol. 2021. PMID: 34417833 Free PMC article.
Here, we describe a molecularly distinct subset of predominantly pediatric CNS neoplasms (n = 60) that harbor PATZ1 fusions. The original histological diagnoses of these tumors covered a wide spectrum of tumor types and malignancy grades. ...RNA sequencing revealed …
Here, we describe a molecularly distinct subset of predominantly pediatric CNS neoplasms (n = 60) that harbor PATZ1 fusions. T …
PATZ1 (MAZR) Co-occupies Genomic Sites With p53 and Inhibits Liver Cancer Cell Proliferation via Regulating p27.
Ng ZL, Siew J, Li J, Ji G, Huang M, Liao X, Yu S, Chew Y, Png CW, Zhang Y, Wen S, Yang H, Zhou Y, Long YC, Jiang ZH, Wu Q. Ng ZL, et al. Front Cell Dev Biol. 2021 Feb 1;9:586150. doi: 10.3389/fcell.2021.586150. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33598459 Free PMC article.
However, the role of PATZ1 in cancer progression remains controversial largely due to lack of genome-wide studies. ...Our PATZ1 ChIP-seq and gene expression microarray analyses revealed that PATZ1 is strongly related to cancer signatures and cel …
However, the role of PATZ1 in cancer progression remains controversial largely due to lack of genome-wide studies. ...Our P …
PATZ1 in Non-Small Cell Lung Cancer: A New Biomarker That Negatively Correlates with PD-L1 Expression and Suppresses the Malignant Phenotype.
Lucà S, Franco R, Napolitano A, Soria V, Ronchi A, Zito Marino F, Della Corte CM, Morgillo F, Fiorelli A, Luciano A, Palma G, Arra C, Battista S, Cerchia L, Fedele M. Lucà S, et al. Cancers (Basel). 2023 Apr 6;15(7):2190. doi: 10.3390/cancers15072190. Cancers (Basel). 2023. PMID: 37046851 Free PMC article.
PATZ1 is an emerging cancer-related transcriptional regulator and diagnostic/prognostic biomarker in different malignant tumors, but its role in lung cancer is still obscure. ...We also showed that PATZ1 overexpression inhibits NSCLC cell proliferation …
PATZ1 is an emerging cancer-related transcriptional regulator and diagnostic/prognostic biomarker in different malignant tumor …
PATZ1 knockdown enhances malignant phenotype in thyroid epithelial follicular cells and thyroid cancer cells.
Iesato A, Nakamura T, Izumi H, Uehara T, Ito KI. Iesato A, et al. Oncotarget. 2017 Aug 2;8(47):82754-82772. doi: 10.18632/oncotarget.19787. eCollection 2017 Oct 10. Oncotarget. 2017. PMID: 29137300 Free PMC article.
This study was designed to examine the involvement of PATZ1 in carcinogenesis and dedifferentiation of thyroid cancer. ...In thyroid cancer cell lines, PATZ1 functioned as a tumor suppressor regardless of p53 status. ...
This study was designed to examine the involvement of PATZ1 in carcinogenesis and dedifferentiation of thyroid cancer. ...In t …
Ewing sarcoma and Ewing-like tumors.
Sbaraglia M, Righi A, Gambarotti M, Dei Tos AP. Sbaraglia M, et al. Virchows Arch. 2020 Jan;476(1):109-119. doi: 10.1007/s00428-019-02720-8. Epub 2019 Dec 4. Virchows Arch. 2020. PMID: 31802230 Review.
Ewing sarcoma (ES) and Ewing-like sarcomas are highly aggressive round cell mesenchymal neoplasms, most often occurring in children and young adults. The identification of novel molecular alterations has greatly contributed to a profound reappraisal of classification, to t …
Ewing sarcoma (ES) and Ewing-like sarcomas are highly aggressive round cell mesenchymal neoplasms, most often occurring in children a …
PATZ1 acts as a tumor suppressor in thyroid cancer via targeting p53-dependent genes involved in EMT and cell migration.
Chiappetta G, Valentino T, Vitiello M, Pasquinelli R, Monaco M, Palma G, Sepe R, Luciano A, Pallante P, Palmieri D, Aiello C, Rea D, Losito SN, Arra C, Fusco A, Fedele M. Chiappetta G, et al. Oncotarget. 2015 Mar 10;6(7):5310-23. doi: 10.18632/oncotarget.2776. Oncotarget. 2015. PMID: 25595894 Free PMC article.
PATZ1, a POZ-Zinc finger protein, is emerging as an important regulator of development and cancer, but its cancer-related function as oncogene or tumor-suppressor is still debated. ...These results provide insights into a potential tumor-suppressor role of …
PATZ1, a POZ-Zinc finger protein, is emerging as an important regulator of development and cancer, but its cancer-relat …
PATZ1 is required for efficient HIV-1 infection.
Aziati ID, Yoshida T, Hamano A, Maeda K, Takeuchi H, Yamaoka S. Aziati ID, et al. Biochem Biophys Res Commun. 2019 Jun 25;514(2):538-544. doi: 10.1016/j.bbrc.2019.04.175. Epub 2019 May 3. Biochem Biophys Res Commun. 2019. PMID: 31060775
Knockdown or knockout of endogenous PATZ1 revealed a supportive role of PATZ1 in HIV-1 infection, but not in transduction with murine leukemia virus-based retroviral vector. More specifically, knockdown or knockout of PATZ1 impaired the viral cDNA synthesis b …
Knockdown or knockout of endogenous PATZ1 revealed a supportive role of PATZ1 in HIV-1 infection, but not in transduction with …
PATZ1-Rearranged Tumors of the Central Nervous System: Characterization of a Pediatric Series of Seven Cases.
Rossi S, Barresi S, Colafati GS, Genovese S, Tancredi C, Costabile V, Patrizi S, Giovannoni I, Asioli S, Poliani PL, Gardiman MP, Cardoni A, Del Baldo G, Antonelli M, Gianno F, Piccirilli E, Catino G, Martucci L, Quacquarini D, Toni F, Melchionda F, Viscardi E, Zucchelli M, Dal Pos S, Gatti E, Liserre R, Schiavello E, Diomedi-Camassei F, Carai A, Mastronuzzi A, Gessi M, Giannini C, Novelli A, Onetti Muda A, Miele E, Alesi V, Alaggio R. Rossi S, et al. Mod Pathol. 2024 Feb;37(2):100387. doi: 10.1016/j.modpat.2023.100387. Epub 2023 Nov 23. Mod Pathol. 2024. PMID: 38007157
PATZ1-rearranged sarcomas are well-recognized tumors as part of the family of round cell sarcoma with EWSR1-non-ETS fusions. Whether PATZ1-rearranged central nervous system (CNS) tumors are a distinct tumor type is debatable. ...
PATZ1-rearranged sarcomas are well-recognized tumors as part of the family of round cell sarcoma with EWSR1-non-ETS fusions. Whether …
Loss of One or Two PATZ1 Alleles Has a Critical Role in the Progression of Thyroid Carcinomas Induced by the RET/PTC1 Oncogene.
Monaco M, Palma G, Vitiello M, Capiluongo A, D'Andrea B, Vuttariello E, Luciano A, Cerchia L, Chiappetta G, Arra C, Fusco A, Fedele M. Monaco M, et al. Cancers (Basel). 2018 Mar 27;10(4):92. doi: 10.3390/cancers10040092. Cancers (Basel). 2018. PMID: 29584698 Free PMC article.
The restoration of PATZ1 expression in thyroid cancer cells reverted their malignant phenotype by inducing mesenchymal-to-epithelial transition, thus validating a tumor suppressor role for PATZ1 and suggesting its involvement in thyroid cancer progress …
The restoration of PATZ1 expression in thyroid cancer cells reverted their malignant phenotype by inducing mesenchymal-to-epit …
PATZ1 interacts with p53 and regulates expression of p53-target genes enhancing apoptosis or cell survival based on the cellular context.
Valentino T, Palmieri D, Vitiello M, Pierantoni GM, Fusco A, Fedele M. Valentino T, et al. Cell Death Dis. 2013 Dec 12;4(12):e963. doi: 10.1038/cddis.2013.500. Cell Death Dis. 2013. PMID: 24336083 Free PMC article.
Indeed, knockdown of PATZ1 in p53-null osteosarcoma cells upregulates BAX expression and decreases survival of 5FU-treated cells, then suggesting an anti-apoptotic role of PATZ1 in p53-null cancer cells. ...Conversely, its opposite and anti-apoptotic role in …
Indeed, knockdown of PATZ1 in p53-null osteosarcoma cells upregulates BAX expression and decreases survival of 5FU-treated cells, the …
84 results