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Genome-wide analysis of high-risk primary brain cancer pedigrees identifies PDXDC1 as a candidate brain cancer predisposition gene.
Cannon-Albright LA, Farnham JM, Stevens J, Teerlink CC, Palmer CA, Rowe K, Cessna MH, Blumenthal DT. Cannon-Albright LA, et al. Neuro Oncol. 2021 Feb 25;23(2):277-283. doi: 10.1093/neuonc/noaa161. Neuro Oncol. 2021. PMID: 32644145 Free PMC article.
BACKGROUND: There is evidence for an inherited contribution to primary brain cancer. Linkage analysis of high-risk brain cancer pedigrees has identified candidate regions of interest in which brain cancer predisposition genes are likely to reside. METHODS: Ge …
BACKGROUND: There is evidence for an inherited contribution to primary brain cancer. Linkage analysis of high-risk brain cancer …
Pdxdc1 modulates prepulse inhibition of acoustic startle in the mouse.
Feldcamp LA, Boutros PC, Raymond R, Fletcher PJ, Nobrega JN, Wong AHC. Feldcamp LA, et al. Transl Psychiatry. 2017 May 9;7(5):e1125. doi: 10.1038/tp.2017.85. Transl Psychiatry. 2017. PMID: 28485732 Free PMC article.
We determined that Pdxdc1 mRNA and protein are both strongly expressed in the hippocampus and levels of Pdxdc1 are inversely correlated with PPI across the six mouse strains. Using shRNA packaged in a lentiviral vector, we suppressed Pdxdc1 protein levels in …
We determined that Pdxdc1 mRNA and protein are both strongly expressed in the hippocampus and levels of Pdxdc1 are inversely c …
Genotype-based gene signature of glioma risk.
Huang YT, Zhang Y, Wu Z, Michaud DS. Huang YT, et al. Neuro Oncol. 2017 Jul 1;19(7):940-950. doi: 10.1093/neuonc/now288. Neuro Oncol. 2017. PMID: 28339748 Free PMC article.
Four novel glioma susceptibility genes were identified with internal and external validation, including DRD5 (P = 3.0 10-79), WDR1 (P = 8.4 10-77), NOMO1 (P = 1.3 10-25), and PDXDC1 (P = 8.3 10-24). The genotype-predicted transcription pattern between cases and controls is …
Four novel glioma susceptibility genes were identified with internal and external validation, including DRD5 (P = 3.0 10-79), WDR1 (P = 8.4 …
Genetically predicted plasma phospholipid arachidonic acid concentrations and 10 site-specific cancers in UK biobank and genetic consortia participants: A mendelian randomization study.
Larsson SC, Carter P, Vithayathil M, Mason AM, Michaëlsson K, Baron JA, Burgess S. Larsson SC, et al. Clin Nutr. 2021 May;40(5):3332-3337. doi: 10.1016/j.clnu.2020.11.004. Epub 2020 Nov 7. Clin Nutr. 2021. PMID: 33199044 Free PMC article.
The associations of those variants with cancer were taken from the UK Biobank (n = 367,643), FinnGen consortium (n = 135,638), International Lung Cancer Consortium (n = 27,209), Prostate Cancer Association Group to Investigate Cancer Associated Alterat …
The associations of those variants with cancer were taken from the UK Biobank (n = 367,643), FinnGen consortium (n = 135,638), Intern …
Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes.
Durinck S, Stawiski EW, Pavía-Jiménez A, Modrusan Z, Kapur P, Jaiswal BS, Zhang N, Toffessi-Tcheuyap V, Nguyen TT, Pahuja KB, Chen YJ, Saleem S, Chaudhuri S, Heldens S, Jackson M, Peña-Llopis S, Guillory J, Toy K, Ha C, Harris CJ, Holloman E, Hill HM, Stinson J, Rivers CS, Janakiraman V, Wang W, Kinch LN, Grishin NV, Haverty PM, Chow B, Gehring JS, Reeder J, Pau G, Wu TD, Margulis V, Lotan Y, Sagalowsky A, Pedrosa I, de Sauvage FJ, Brugarolas J, Seshagiri S. Durinck S, et al. Nat Genet. 2015 Jan;47(1):13-21. doi: 10.1038/ng.3146. Epub 2014 Nov 17. Nat Genet. 2015. PMID: 25401301 Free PMC article.
To further understand the molecular distinctions between kidney cancer subtypes, we analyzed exome, transcriptome and copy number alteration data from 167 primary human tumors that included renal oncocytomas and non-clear cell renal cell carcinomas (nccRCCs), consisting of …
To further understand the molecular distinctions between kidney cancer subtypes, we analyzed exome, transcriptome and copy number alt …
A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population.
Dorajoo R, Sun Y, Han Y, Ke T, Burger A, Chang X, Low HQ, Guan W, Lemaitre RN, Khor CC, Yuan JM, Koh WP, Ong CN, Tai ES, Liu J, van Dam RM, Heng CK, Friedlander Y. Dorajoo R, et al. Genes Nutr. 2015 Nov;10(6):53. doi: 10.1007/s12263-015-0502-2. Epub 2015 Nov 19. Genes Nutr. 2015. PMID: 26584805 Free PMC article.
We further replicated the associations between common index variants at the NTAN1/PDXDC1 locus and n-6 PUFAs LA and DGLA, and between the JMJD1C locus and n-6 PUFA LA (p value between 0.0490 and 9.88 10(-4)). ...
We further replicated the associations between common index variants at the NTAN1/PDXDC1 locus and n-6 PUFAs LA and DGLA, and between …