Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2010 1
2013 3
2016 1
2017 1
2018 5
2019 5
2020 3
2021 5
2022 2
2023 9
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

35 results

Results by year

Filters applied: . Clear all
Page 1
Acetylation of PHF5A Modulates Stress Responses and Colorectal Carcinogenesis through Alternative Splicing-Mediated Upregulation of KDM3A.
Wang Z, Yang X, Liu C, Li X, Zhang B, Wang B, Zhang Y, Song C, Zhang T, Liu M, Liu B, Ren M, Jiang H, Zou J, Liu X, Zhang H, Zhu WG, Yin Y, Zhang Z, Gu W, Luo J. Wang Z, et al. Mol Cell. 2019 Jun 20;74(6):1250-1263.e6. doi: 10.1016/j.molcel.2019.04.009. Epub 2019 May 1. Mol Cell. 2019. PMID: 31054974 Free article.
Pathologically, PHF5A K29 hyperacetylation and KDM3A upregulation axis are correlated with poor prognosis of colon cancer. Our findings uncover a mechanism of an anti-stress pathway through which acetylation on PHF5A promotes the cancer cells' capacity …
Pathologically, PHF5A K29 hyperacetylation and KDM3A upregulation axis are correlated with poor prognosis of colon cancer. Our …
PHF5A facilitates the development and progression of gastric cancer through SKP2-mediated stabilization of FOS.
Zhang Z, Peng L, Yang W, Li B, Hua Y, Luo S. Zhang Z, et al. J Transl Med. 2023 Jan 6;21(1):5. doi: 10.1186/s12967-022-03821-w. J Transl Med. 2023. PMID: 36609277 Free PMC article.
BACKGROUND: Gastric cancer (GC) is the fifth most common cancer and the third most common cause of cancer death worldwide. Plant homeodomain (PHD)-finger domain protein PHF5A has been demonstrated to play a promoting role in a variety of cancers …
BACKGROUND: Gastric cancer (GC) is the fifth most common cancer and the third most common cause of cancer death worldwi …
PHF5A is a potential diagnostic, prognostic, and immunological biomarker in pan-cancer.
Ding N, Li M, Zhao X. Ding N, et al. Sci Rep. 2023 Oct 16;13(1):17521. doi: 10.1038/s41598-023-44899-6. Sci Rep. 2023. PMID: 37845358 Free PMC article.
Studying the molecular mechanisms and regulatory functions of genes is crucial for exploring new approaches and tactics in cancer therapy. Studies have shown that the aberrant expression of PHF5A in tumors is linked to the origin and advancement of multiple cance …
Studying the molecular mechanisms and regulatory functions of genes is crucial for exploring new approaches and tactics in cancer the …
PHF5A Epigenetically Inhibits Apoptosis to Promote Breast Cancer Progression.
Zheng YZ, Xue MZ, Shen HJ, Li XG, Ma D, Gong Y, Liu YR, Qiao F, Xie HY, Lian B, Sun WL, Zhao HY, Yao L, Zuo WJ, Li DQ, Wang P, Hu X, Shao ZM. Zheng YZ, et al. Cancer Res. 2018 Jun 15;78(12):3190-3206. doi: 10.1158/0008-5472.CAN-17-3514. Epub 2018 Apr 26. Cancer Res. 2018. PMID: 29700004
Using an in vivo CRISPR screen targeting RNA-binding proteins, we identified PHD finger protein 5A (PHF5A) as a key splicing factor involved in tumor progression. PHF5A expression was frequently upregulated in breast cancer and correlated with poor survival, …
Using an in vivo CRISPR screen targeting RNA-binding proteins, we identified PHD finger protein 5A (PHF5A) as a key splicing factor i …
RNA Polymerase II-Associated Factor 1 Regulates Stem Cell Features of Pancreatic Cancer Cells, Independently of the PAF1 Complex, via Interactions With PHF5A and DDX3.
Karmakar S, Rauth S, Nallasamy P, Perumal N, Nimmakayala RK, Leon F, Gupta R, Barkeer S, Venkata RC, Raman V, Rachagani S, Ponnusamy MP, Batra SK. Karmakar S, et al. Gastroenterology. 2020 Nov;159(5):1898-1915.e6. doi: 10.1053/j.gastro.2020.07.053. Epub 2020 Aug 8. Gastroenterology. 2020. PMID: 32781084 Free PMC article.
BACKGROUND & AIMS: It is not clear how pancreatic cancer stem cells (CSCs) are regulated, resulting in ineffective treatments for pancreatic cancer. ...Knockdown of PAF1 reduces the ability of orthotopic pancreatic tumors to develop and progress in mice and thei …
BACKGROUND & AIMS: It is not clear how pancreatic cancer stem cells (CSCs) are regulated, resulting in ineffective treatments for …
PHF5A Contributes to the Maintenance of the Cancer Stem-like Phenotype in Non-Small Cell Lung Cancer by Regulating Histone Deacetylase 8.
Yang Y, Li M, Zhou X, Wang W, Shao Y, Yao J, Wang X. Yang Y, et al. Ann Clin Lab Sci. 2022 May;52(3):439-451. Ann Clin Lab Sci. 2022. PMID: 35777798
PHD-finger domain protein 5A (PHF5A) is related to tumorigenesis and development of non-small cell lung cancer (NSCLC). The role and regulatory mechanism of PHF5A in CSLCs of NSCLC remain unclear. This study aimed to identify the biological characteristics of …
PHD-finger domain protein 5A (PHF5A) is related to tumorigenesis and development of non-small cell lung cancer (NSCLC). The ro …
KMT2A associates with PHF5A-PHF14-HMG20A-RAI1 subcomplex in pancreatic cancer stem cells and epigenetically regulates their characteristics.
Mouti MA, Deng S, Pook M, Malzahn J, Rendek A, Militi S, Nibhani R, Soonawalla Z, Oppermann U, Hwang CI, Pauklin S. Mouti MA, et al. Nat Commun. 2023 Sep 14;14(1):5685. doi: 10.1038/s41467-023-41297-4. Nat Commun. 2023. PMID: 37709746 Free PMC article.
Pancreatic cancer (PC), one of the most aggressive and life-threatening human malignancies, is known for its resistance to cytotoxic therapies. ...Here, we identify the histone methyltransferase KMT2A as a physical binding partner of an RNA polymerase-associated PHF5A …
Pancreatic cancer (PC), one of the most aggressive and life-threatening human malignancies, is known for its resistance to cytotoxic …
PHF5A as a new OncoTarget and therapeutic prospects.
Li X, Liu D, Wang Y, Chen Y, Wang C, Lin Z, Tian L. Li X, et al. Heliyon. 2023 Jul 6;9(7):e18010. doi: 10.1016/j.heliyon.2023.e18010. eCollection 2023 Jul. Heliyon. 2023. PMID: 37483794 Free PMC article. Review.
Further, the participation of PHF5A in regulating the growth of cancer stem cells might not be ignored. The current review briefly overviews the structural and functional attributes of PHF5A along with its hitherto described role in the propagation of canc …
Further, the participation of PHF5A in regulating the growth of cancer stem cells might not be ignored. The current review bri …
Plant homeodomain-finger protein 5A: A key player in cancer progression.
Diaba-Nuhoho P. Diaba-Nuhoho P. Biomed Pharmacother. 2023 Dec 31;169:115857. doi: 10.1016/j.biopha.2023.115857. Epub 2023 Nov 9. Biomed Pharmacother. 2023. PMID: 37951028 Free article. Review.
PHF5A is implicated in the regulation of cancer cell proliferation, invasion, migration and metastasis. Knockdown of PHF5A prevented the invasion and metastasis of tumor cells. Here, the role of PHF5A in different cancers and their possible mech …
PHF5A is implicated in the regulation of cancer cell proliferation, invasion, migration and metastasis. Knockdown of PHF5A …
PHF5A promotes colorectal cancerprogression by alternative splicing of TEAD2.
Chang Y, Zhao Y, Wang L, Wu M, He C, Huang M, Lei Z, Yang J, Han S, Wang B, Chen Y, Liu C, Yu H, Xue L, Geng J, Chen Y, Dai T, Ren L, Wang Q, Liu X, Chu X, Chen C. Chang Y, et al. Mol Ther Nucleic Acids. 2021 Nov 3;26:1215-1227. doi: 10.1016/j.omtn.2021.10.025. eCollection 2021 Dec 3. Mol Ther Nucleic Acids. 2021. PMID: 34853721 Free PMC article.
Here, we demonstrated that PHF5A, a component of U2 small nuclear ribonucleoproteins, was frequently upregulated in colorectal cancer (CRC) samples and associated with poor prognosis. ...Pharmacological inhibition of PHF5A using pladienolide B had potent anti …
Here, we demonstrated that PHF5A, a component of U2 small nuclear ribonucleoproteins, was frequently upregulated in colorectal can …
35 results