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An alternative POLDIP3 transcript promotes hepatocellular carcinoma progression.
Liu XN, Yuan JH, Wang TT, Pan W, Sun SH. Liu XN, et al. Biomed Pharmacother. 2017 May;89:276-283. doi: 10.1016/j.biopha.2017.01.139. Epub 2017 Feb 24. Biomed Pharmacother. 2017. PMID: 28236701
Alternative splicing plays critical roles in many pathophysiological processes and splicing dysregulation is a hallmark of cancer. The different isoforms may have significantly different effects on cancers. ...In this study, we measured the expression of an alternat …
Alternative splicing plays critical roles in many pathophysiological processes and splicing dysregulation is a hallmark of cancer. Th …
The polymerase δ-interacting protein family and their emerging roles in diseases.
Huang P, Wu L, Zhu N, Zhao H, Du J. Huang P, et al. Front Med (Lausanne). 2022 Nov 8;9:1026931. doi: 10.3389/fmed.2022.1026931. eCollection 2022. Front Med (Lausanne). 2022. PMID: 36425112 Free PMC article. Review.
The members of the POLDIP family include POLDIP1, POLDIP2, and POLDIP3. Screened by the two-hybrid method, POLDIP1, POLDIP2, and POLDIP3 were initially discovered and named for their ability to bind to the p50 subunit of DNA polymerase delta. ...Finally, to provide …
The members of the POLDIP family include POLDIP1, POLDIP2, and POLDIP3. Screened by the two-hybrid method, POLDIP1, POLDIP2, and P …
Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution.
Björkman A, Johansen SL, Lin L, Schertzer M, Kanellis DC, Katsori AM, Christensen ST, Luo Y, Andersen JS, Elsässer SJ, Londono-Vallejo A, Bartek J, Schou KB. Björkman A, et al. Genes Dev. 2020 Aug 1;34(15-16):1065-1074. doi: 10.1101/gad.330050.119. Epub 2020 Jun 19. Genes Dev. 2020. PMID: 32561545 Free PMC article.
Loss of RTEL1 and Poldip3 leads to marked R-loop accumulation that is confined to sites of active replication, enhances endogenous replication stress, and fuels ensuing genomic instability. ...Overall, our data highlight a previously unsuspected role of RTEL1 and Poldip …
Loss of RTEL1 and Poldip3 leads to marked R-loop accumulation that is confined to sites of active replication, enhances endogenous re …
Comprehensive Characterization of RNA Processing Factors in Gastric Cancer Identifies a Prognostic Signature for Predicting Clinical Outcomes and Therapeutic Responses.
Lou S, Meng F, Yin X, Zhang Y, Han B, Xue Y. Lou S, et al. Front Immunol. 2021 Aug 3;12:719628. doi: 10.3389/fimmu.2021.719628. eCollection 2021. Front Immunol. 2021. PMID: 34413861 Free PMC article.
This study included 1079 GC cases from The Cancer Genome Atlas (TCGA, training set), our hospital cohort, and two other external validation sets (GSE15459, GSE62254). ...A 10-gene RNA processing-related prognostic signature, involving ZBTB7A, METTL2B, CACTIN, TRUB2, POL …
This study included 1079 GC cases from The Cancer Genome Atlas (TCGA, training set), our hospital cohort, and two other external vali …
Interactions between KSHV ORF57 and the novel human TREX proteins, CHTOP and CIP29.
Schumann S, Baquero-Perez B, Whitehouse A. Schumann S, et al. J Gen Virol. 2016 Aug;97(8):1904-1910. doi: 10.1099/jgv.0.000503. Epub 2016 May 16. J Gen Virol. 2016. PMID: 27189710 Free PMC article.
Recently, additional cellular proteins, namely CHTOP, CIP29 and POLDIP3 have been proposed as novel hTREX components. Herein, we extend our previous research and provide evidence that ORF57 interacts with CHTOP and CIP29, in contrast to POLDIP3. ...
Recently, additional cellular proteins, namely CHTOP, CIP29 and POLDIP3 have been proposed as novel hTREX components. Herein, we exte …
Acquired genetic alterations in tumor cells dictate the development of high-risk neuroblastoma and clinical outcomes.
Khan FH, Pandian V, Ramraj S, Natarajan M, Aravindan S, Herman TS, Aravindan N. Khan FH, et al. BMC Cancer. 2015 Jul 10;15:514. doi: 10.1186/s12885-015-1463-y. BMC Cancer. 2015. PMID: 26159519 Free PMC article.
Array CGH analysis of individual clones of MSDACs revealed genetic alterations in chromosomes 1, 7, 8, and 22, corresponding to a gain in the copy numbers of LOC100288142, CD1C, CFHR3, FOXP2, MDFIC, RALYL, CSMD3, SAMD12-AS1, and MAL2, and a loss in ADAM5, LOC400927, APOBEC3B, RPL …
Array CGH analysis of individual clones of MSDACs revealed genetic alterations in chromosomes 1, 7, 8, and 22, corresponding to a gain in th …
In search of antiaging modalities: evaluation of mTOR- and ROS/DNA damage-signaling by cytometry.
Darzynkiewicz Z, Zhao H, Halicka HD, Li J, Lee YS, Hsieh TC, Wu JM. Darzynkiewicz Z, et al. Cytometry A. 2014 May;85(5):386-99. doi: 10.1002/cyto.a.22452. Epub 2014 Feb 22. Cytometry A. 2014. PMID: 24677687 Free PMC article. Review.
While the primary target of each of these agents may be different the data obtained on several human cancer cell lines, WI-38 fibroblasts and normal lymphocytes suggest common downstream mechanism in which the decline in mTOR/S6K1 signaling and translation rate is coupled …
While the primary target of each of these agents may be different the data obtained on several human cancer cell lines, WI-38 fibrobl …
Host genome variations and risk of infections during induction treatment for childhood acute lymphoblastic leukaemia.
Lund B, Wesolowska-Andersen A, Lausen B, Borst L, Rasmussen KK, Müller K, Klungland H, Gupta R, Schmiegelow K. Lund B, et al. Eur J Haematol. 2014 Apr;92(4):321-30. doi: 10.1111/ejh.12243. Epub 2014 Jan 28. Eur J Haematol. 2014. PMID: 24330153
Classification and regression tree analysis demonstrated rs11033797 (OR51F1), rs2835265 (CBR1), rs28627172 (POLDIP3) and rs1129844 (CCL11) to be predictive of outcome. Among 61 patients for whom read-outs were available for all four SNPs, 40 of 41 patients with the worst S …
Classification and regression tree analysis demonstrated rs11033797 (OR51F1), rs2835265 (CBR1), rs28627172 (POLDIP3) and rs1129844 (C …
From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.
Colombrita C, Onesto E, Buratti E, de la Grange P, Gumina V, Baralle FE, Silani V, Ratti A. Colombrita C, et al. Biochim Biophys Acta. 2015 Dec;1849(12):1398-410. doi: 10.1016/j.bbagrm.2015.10.015. Epub 2015 Oct 26. Biochim Biophys Acta. 2015. PMID: 26514432
In particular, TDP-43 and FUS were found to regulate splicing and expression of genes related to neuronal (SEPT6, SULT4A1, TNIK) and RNA metabolism (DICER, ELAVL3/HuC, POLDIP3). Our extended analysis at protein level revealed that these changes have also impact on the prot …
In particular, TDP-43 and FUS were found to regulate splicing and expression of genes related to neuronal (SEPT6, SULT4A1, TNIK) and RNA met …
The endoplasmic reticulum stress-inducible protein Niban regulates eIF2alpha and S6K1/4E-BP1 phosphorylation.
Sun GD, Kobayashi T, Abe M, Tada N, Adachi H, Shiota A, Totsuka Y, Hino O. Sun GD, et al. Biochem Biophys Res Commun. 2007 Aug 17;360(1):181-7. doi: 10.1016/j.bbrc.2007.06.021. Epub 2007 Jun 12. Biochem Biophys Res Commun. 2007. PMID: 17588536
The Niban/NIBAN gene is specifically expressed in hereditary renal carcinomas of model animals and in human malignancies, including renal cancers. Although the expression profiles of Niban/NIBAN suggest that it plays an important role in carcinogenesis, no functional infor …
The Niban/NIBAN gene is specifically expressed in hereditary renal carcinomas of model animals and in human malignancies, including renal …
12 results