Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
1993 2
2005 1
2006 5
2007 15
2008 18
2009 20
2010 13
2011 17
2012 16
2013 26
2014 18
2015 13
2016 15
2017 18
2018 19
2019 20
2020 20
2021 24
2022 19
2023 21
2024 18

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

308 results

Results by year

Filters applied: . Clear all
Page 1
PPP2CA Is a Novel Therapeutic Target in Neuroblastoma Cells That Can Be Activated by the SET Inhibitor OP449.
Galiger C, Dahlhaus M, Vitek MP, Debatin KM, Beltinger C. Galiger C, et al. Front Oncol. 2022 Jun 22;12:744984. doi: 10.3389/fonc.2022.744984. eCollection 2022. Front Oncol. 2022. PMID: 35814385 Free PMC article.
Protein phosphatase 2 (PP2A) with its catalytic subunit PPP2CA is a major phosphatase in cancer cells, including NB. We show that reduction of PPP2CA by knock-down decreased growth of NB cells and that complete ablation of PPP2CA by knock-out was not tolerate …
Protein phosphatase 2 (PP2A) with its catalytic subunit PPP2CA is a major phosphatase in cancer cells, including NB. We show that red …
Ppp2ca knockout in mice spermatogenesis.
Pan X, Chen X, Tong X, Tang C, Li J. Pan X, et al. Reproduction. 2015 Apr;149(4):385-91. doi: 10.1530/REP-14-0231. Epub 2015 Jan 27. Reproduction. 2015. PMID: 25628439
We generated a Ppp2ca conditional knockout (CKO) in C57BL/6J mice. Exon 2 of Ppp2ca was knocked out in a spatial or temporal-specific manner in primordial germ cells at E12.5. This Ppp2ca-null mutation caused infertility in male C57BL/6J mice. These CKO mice …
We generated a Ppp2ca conditional knockout (CKO) in C57BL/6J mice. Exon 2 of Ppp2ca was knocked out in a spatial or temporal-s …
The miR-345-3p/PPP2CA signaling axis promotes proliferation and invasion of breast cancer cells.
Zeng Q, Jin F, Qian H, Chen H, Wang Y, Zhang D, Wei Y, Chen T, Guo B, Chai C. Zeng Q, et al. Carcinogenesis. 2022 Mar 24;43(2):150-159. doi: 10.1093/carcin/bgab124. Carcinogenesis. 2022. PMID: 34922339 Free PMC article.
Further research identified protein phosphatase 2 catalytic subunit alpha (PPP2CA), a suppressor of AKT phosphorylation, as a candidate target of miR-345-3p. In vitro, miR-345-3p mimics promoted AKT phosphorylation by targeting its negative regulator, PPP2CA. ...Tog …
Further research identified protein phosphatase 2 catalytic subunit alpha (PPP2CA), a suppressor of AKT phosphorylation, as a candida …
Establishment of a PPP2CA homozygous knockout human embryonic stem cell line via CRISPR/Cas9 system.
Ding T, Gao Z, Liu H, Li Y, Liu S, Jian L. Ding T, et al. Stem Cell Res. 2023 Mar;67:103029. doi: 10.1016/j.scr.2023.103029. Epub 2023 Jan 16. Stem Cell Res. 2023. PMID: 36724553 Free article.
Protein phosphatase 2A (PPP2CA) is one of the four main Ser/Thr phosphatase enzymes, which involved in the negative control of cell growth and division. PPP2CA is the main protein phosphatase in the heart, which regulates Ca (2+) through a series of ion channels and …
Protein phosphatase 2A (PPP2CA) is one of the four main Ser/Thr phosphatase enzymes, which involved in the negative control of cell g …
The effect of PPP2CA expression on the prognosis of patients with hepatocellular carcinoma and its molecular biological characteristics.
Liang J, Huang Y, Yang C, Huang S, Xie J, Nong X, Liu J, Zhang Y, Zhang Z. Liang J, et al. J Gastrointest Oncol. 2021 Dec;12(6):3008-3021. doi: 10.21037/jgo-21-720. J Gastrointest Oncol. 2021. PMID: 35070426 Free PMC article.
RESULTS: The immunohistochemistry (IHC) of tissue sections confirmed that PPP2CA was highly expressed in most HCC tissues; the high expression of PPP2CA was significantly correlated with microvascular invasion (MVI) and portal vein tumor thrombi (P<0.05). ...Thro …
RESULTS: The immunohistochemistry (IHC) of tissue sections confirmed that PPP2CA was highly expressed in most HCC tissues; the high e …
Potential Role and Clinical Value of PPP2CA in Hepatocellular Carcinoma.
Yang CL, Qiu X, Lin JY, Chen XY, Zhang YM, Hu XY, Zhong JH, Tang S, Li XY, Xiang BD, Zhang ZM. Yang CL, et al. J Clin Transl Hepatol. 2021 Oct 28;9(5):661-671. doi: 10.14218/JCTH.2020.00168. Epub 2021 May 13. J Clin Transl Hepatol. 2021. PMID: 34722181 Free PMC article.
Immunohistochemistry of tissue sections confirmed that PPP2CA protein was up-regulated in HCC tissues. High PPP2CA expression in HCC patients was associated with shorter overall, progression-free and disease-free survival. ...CONCLUSIONS: PPP2CA is up-regulat …
Immunohistochemistry of tissue sections confirmed that PPP2CA protein was up-regulated in HCC tissues. High PPP2CA expression …
PPP2CA Inhibition Promotes Ferroptosis Sensitivity Through AMPK/SCD1 Pathway in Colorectal Cancer.
Liang X, Zhang H, Shang W, Wang M, Li J, Zhao Y, Fang C. Liang X, et al. Dig Dis Sci. 2024 Jun;69(6):2083-2095. doi: 10.1007/s10620-024-08416-7. Epub 2024 Apr 18. Dig Dis Sci. 2024. PMID: 38637456
Besides, we found that the inhibition of PPP2CA further led to the suppression of SCD1 expression in CRC cells in a AMPK-dependent way. CONCLUSION: Ultimately, we conclude that PPP2CA may regulate Erastin-induced ferroptosis through AMPK/SCD1 signaling pathway....
Besides, we found that the inhibition of PPP2CA further led to the suppression of SCD1 expression in CRC cells in a AMPK-dependent wa …
Mapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA.
Brewer A, Sathe G, Pflug BE, Clarke RG, Macartney TJ, Sapkota GP. Brewer A, et al. iScience. 2024 Feb 19;27(3):109302. doi: 10.1016/j.isci.2024.109302. eCollection 2024 Mar 15. iScience. 2024. PMID: 38450154 Free PMC article.
To address this, we employed dTAG proteolysis-targeting chimeras to efficiently and selectively degrade dTAG-PPP2CA in homozygous knock-in HEK293 cells. Unbiased global phospho-proteomics identified 2,204 proteins with significantly increased phosphorylation upon dTAG-P …
To address this, we employed dTAG proteolysis-targeting chimeras to efficiently and selectively degrade dTAG-PPP2CA in homozygous kno …
Genetic variants in PPP2CA are associated with gastric cancer risk in a Chinese population.
Huang T, He K, Mao Y, Zhu M, Yan C, Yu F, Qi Q, Wang T, Wang Y, Du J, Liu L. Huang T, et al. Sci Rep. 2017 Sep 13;7(1):11499. doi: 10.1038/s41598-017-12040-z. Sci Rep. 2017. PMID: 28904398 Free PMC article.
Therefore, we hypothesized that genetic variants in PPP2CA might influence susceptibility of gastric cancer. To test this hypothesis, three tagging single nucleotide polymorphisms (SNPs) in PPP2CA were genotyped in a case-control study including 1,113 cases and 1,84 …
Therefore, we hypothesized that genetic variants in PPP2CA might influence susceptibility of gastric cancer. To test this hypothesis, …
308 results