Acute lung injury is reduced by the α7nAChR agonist PNU-282987 through changes in the macrophage profile.
Pinheiro NM, Santana FP, Almeida RR, Guerreiro M, Martins MA, Caperuto LC, Câmara NO, Wensing LA, Prado VF, Tibério IF, Prado MA, Prado CM.
Pinheiro NM, et al.
FASEB J. 2017 Jan;31(1):320-332. doi: 10.1096/fj.201600431R. Epub 2016 Oct 11.
FASEB J. 2017.
PMID: 27729414
The collective results suggest that PNU-282987, an agonist of alpha7nAChR, reduces LPS-induced experimental ALI, thus supporting the notion that drugs that act on alpha7nAChRs should be explored for ARDS treatment in humans.-Pinheiro, N. M., Santana, F. P. R., Almei …
The collective results suggest that PNU-282987, an agonist of alpha7nAChR, reduces LPS-induced experimental ALI, thus supporting the notion …