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Novel gold(I) complexes induce apoptosis in leukemia cells via the ROS-induced mitochondrial pathway with an upregulation of Harakiri and overcome multi drug resistances in leukemia and lymphoma cells and sensitize drug resistant tumor cells to apoptosis in vitro.
Ahrweiler-Sawaryn MC, Biswas A, Frias C, Frias J, Wilke NL, Wilke N, Berkessel A, Prokop A. Ahrweiler-Sawaryn MC, et al. Among authors: prokop a. Biomed Pharmacother. 2023 May;161:114507. doi: 10.1016/j.biopha.2023.114507. Epub 2023 Mar 21. Biomed Pharmacother. 2023. PMID: 36958194 Free article.
Unusual eta2-allene osmacycle with apoptotic properties.
He X, Gong L, Kräling K, Gründler K, Frias C, Webster RD, Meggers E, Prokop A, Xia H. He X, et al. Among authors: prokop a. Chembiochem. 2010 Jul 26;11(11):1607-13. doi: 10.1002/cbic.201000055. Chembiochem. 2010. PMID: 20575131
[NiII(3-OMe-salophene)]: a potent agent with antitumor activity.
Lee SY, Hille A, Frias C, Kater B, Bonitzki B, Wölfl S, Scheffler H, Prokop A, Gust R. Lee SY, et al. Among authors: prokop a. J Med Chem. 2010 Aug 26;53(16):6064-70. doi: 10.1021/jm100459k. J Med Chem. 2010. PMID: 20669965
Organometallic nucleosides induce non-classical leukemic cell death that is mitochondrial-ROS dependent and facilitated by TCL1-oncogene burden.
Prinz C, Vasyutina E, Lohmann G, Schrader A, Romanski S, Hirschhäuser C, Mayer P, Frias C, Herling CD, Hallek M, Schmalz HG, Prokop A, Mougiakakos D, Herling M. Prinz C, et al. Among authors: prokop a. Mol Cancer. 2015 Jun 4;14:114. doi: 10.1186/s12943-015-0378-1. Mol Cancer. 2015. PMID: 26041471 Free PMC article.
386 results