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Page 1
Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer.
Nissim S, Leshchiner I, Mancias JD, Greenblatt MB, Maertens O, Cassa CA, Rosenfeld JA, Cox AG, Hedgepeth J, Wucherpfennig JI, Kim AJ, Henderson JE, Gonyo P, Brandt A, Lorimer E, Unger B, Prokop JW, Heidel JR, Wang XX, Ukaegbu CI, Jennings BC, Paulo JA, Gableske S, Fierke CA, Getz G, Sunyaev SR, Wade Harper J, Cichowski K, Kimmelman AC, Houvras Y, Syngal S, Williams C, Goessling W. Nissim S, et al. Nat Genet. 2019 Sep;51(9):1308-1314. doi: 10.1038/s41588-019-0475-y. Epub 2019 Aug 12. Nat Genet. 2019. PMID: 31406347 Free PMC article.
Heterozygous rabl3 mutant zebrafish show increased susceptibility to cancer formation. Transcriptomic and mass spectrometry approaches implicate RABL3 in RAS pathway regulation and identify an interaction with RAP1GDS1 (SmgGDS), a chaperone regulating prenylation of …
Heterozygous rabl3 mutant zebrafish show increased susceptibility to cancer formation. Transcriptomic and mass spectrometry approache …
GTPase splice variants RAC1 and RAC1B display isoform-specific differences in localization, prenylation, and interaction with the chaperone protein SmgGDS.
Koehn OJ, Lorimer E, Unger B, Harris R, Das AS, Suazo KF, Auger SA, Distefano MD, Prokop JW, Williams CL. Koehn OJ, et al. J Biol Chem. 2023 Jun;299(6):104698. doi: 10.1016/j.jbc.2023.104698. Epub 2023 Apr 12. J Biol Chem. 2023. PMID: 37059183 Free PMC article.
Identifying events that regulate the prenylation and localization of small GTPases will help define new strategies for therapeutic targeting of these proteins in disorders such as cancer, cardiovascular disease, and neurological deficits. Splice variants of the chaperone p …
Identifying events that regulate the prenylation and localization of small GTPases will help define new strategies for therapeutic targeting …
t(4;11)(q21;p15) translocation involving NUP98 and RAP1GDS1 genes: characterization of a new subset of T acute lymphoblastic leukaemia.
Mecucci C, La Starza R, Negrini M, Sabbioni S, Crescenzi B, Leoni P, Di Raimondo F, Krampera M, Cimino G, Tafuri A, Cuneo A, Vitale A, Foà R. Mecucci C, et al. Br J Haematol. 2000 Jun;109(4):788-93. doi: 10.1046/j.1365-2141.2000.02106.x. Br J Haematol. 2000. PMID: 10929031 Free article.
In both cases, the molecular characterization showed an involvement of the NUP98 gene on 11p15 which rearranges with the RAP1GDS1 gene on 4q21. The morphological and immunological features of the leukaemic cells, as well as the clinical behaviour and response to induction …
In both cases, the molecular characterization showed an involvement of the NUP98 gene on 11p15 which rearranges with the RAP1GDS1 gen …
The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia.
Hussey DJ, Nicola M, Moore S, Peters GB, Dobrovic A. Hussey DJ, et al. Blood. 1999 Sep 15;94(6):2072-9. Blood. 1999. PMID: 10477737 Free article.
In the NUP98-RAP1GDS1 fusion transcript (abbreviated as NRG), the 5' end of the NUP98 gene is joined in frame to the coding region of the RAP1GDS1 gene. ...This is the first report of an NUP98 translocation in lymphocytic leukemia and the first time that RAP1GDS1 …
In the NUP98-RAP1GDS1 fusion transcript (abbreviated as NRG), the 5' end of the NUP98 gene is joined in frame to the coding region of …
SmgGDS: An Emerging Master Regulator of Prenylation and Trafficking by Small GTPases in the Ras and Rho Families.
Brandt AC, Koehn OJ, Williams CL. Brandt AC, et al. Front Mol Biosci. 2021 Jun 16;8:685135. doi: 10.3389/fmolb.2021.685135. eCollection 2021. Front Mol Biosci. 2021. PMID: 34222337 Free PMC article. Review.
Understanding how prenylation and trafficking are regulated will help define new therapeutic strategies for cancer and other disorders involving abnormal signaling by these small GTPases. ...We conclude with a discussion of current strategies for therapeutic targeting of S …
Understanding how prenylation and trafficking are regulated will help define new therapeutic strategies for cancer and other disorder …
Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells.
Bowler E, Porazinski S, Uzor S, Thibault P, Durand M, Lapointe E, Rouschop KMA, Hancock J, Wilson I, Ladomery M. Bowler E, et al. BMC Cancer. 2018 Apr 2;18(1):355. doi: 10.1186/s12885-018-4227-7. BMC Cancer. 2018. PMID: 29606096 Free PMC article.
RESULTS: In PC3 cells the exon inclusion rate PSI (psi) was seen to change by > 25% in 12 cancer-associated genes; MBP, APAF1, PUF60, SYNE2, CDC42BPA, FGFR10P, BTN2A2, UTRN, RAP1GDS1, PTPN13, TTC23 and CASP9 (caspase 9). ...CONCLUSIONS: Significant changes in alt …
RESULTS: In PC3 cells the exon inclusion rate PSI (psi) was seen to change by > 25% in 12 cancer-associated genes; MBP, APAF1, PUF …
NUP98/11p15 translocations affect CD34+ cells in myeloid and T lymphoid leukemias.
Crescenzi B, Nofrini V, Barba G, Matteucci C, Di Giacomo D, Gorello P, Beverloo B, Vitale A, Wlodarska I, Vandenberghe P, La Starza R, Mecucci C. Crescenzi B, et al. Leuk Res. 2015 Jul;39(7):769-72. doi: 10.1016/j.leukres.2015.04.014. Epub 2015 May 7. Leuk Res. 2015. PMID: 26004809 Free article.
Single cell analysis by FICTION (Fluorescence Immunophenotype and Interphase Cytogenetics as a Tool for Investigation of Neoplasms) showed that, despite diverse partners, i.e. NSD1, DDX10, RAP1GDS1, and LNP1, NUP98 translocations always affected a CD34+/CD133+ hemat …
Single cell analysis by FICTION (Fluorescence Immunophenotype and Interphase Cytogenetics as a Tool for Investigation of Neoplasms) s …
Molecular evaluation of the NUP98/RAP1GDS1 gene frequency in adults with T-acute lymphoblastic leukemia.
Cimino G, Sprovieri T, Rapanotti MC, Foà R, Mecucci C, Mandelli F. Cimino G, et al. Haematologica. 2001 Apr;86(4):436-7. Haematologica. 2001. PMID: 11325654
The NUP98/RAP1GDS1 (NRG) is a new fusion gene, originating from the t(4;11)(q21;p15) translocation, that characterizes a subset of T-cell acute lymphoblastic leukemia (T-ALL). ...
The NUP98/RAP1GDS1 (NRG) is a new fusion gene, originating from the t(4;11)(q21;p15) translocation, that characterizes a subset of T- …
The SmgGDS splice variant SmgGDS-558 is a key promoter of tumor growth and RhoA signaling in breast cancer.
Hauser AD, Bergom C, Schuld NJ, Chen X, Lorimer EL, Huang J, Mackinnon AC, Williams CL. Hauser AD, et al. Mol Cancer Res. 2014 Jan;12(1):130-42. doi: 10.1158/1541-7786.MCR-13-0362. Epub 2013 Nov 6. Mol Cancer Res. 2014. PMID: 24197117 Free PMC article.
Breast cancer malignancy is promoted by the small GTPases RhoA and RhoC. ...Taken together, these findings define SmgGDS-558 as a unique promoter of RhoA and NF-kappaB activity and a novel therapeutic target in breast cancer. IMPLICATIONS: This study defines a new m …
Breast cancer malignancy is promoted by the small GTPases RhoA and RhoC. ...Taken together, these findings define SmgGDS-558 as a uni …
34 results