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Ruthenium catalysed cross metathesis with fluorinated olefins.
Chem Commun (Camb). 2001 Sep 7;(17):1692-3. doi: 10.1039/b105031c.
Chem Commun (Camb). 2001.
PMID: 12240447
Ring opening-cross metathesis of unstrained cycloalkenes.
Randl S, Connon SJ, Blechert S.
Randl S, et al.
Chem Commun (Camb). 2001 Sep 21;(18):1796-7.
Chem Commun (Camb). 2001.
PMID: 12240319
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Concise enantioselective synthesis of 3,5-dialkyl-substituted indolizidine alkaloids via sequential cross-metathesis-double-reductive cyclization.
Randl S, Blechert S.
Randl S, et al.
J Org Chem. 2003 Nov 14;68(23):8879-82. doi: 10.1021/jo0346095.
J Org Chem. 2003.
PMID: 14604357
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Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D.
Vulpetti A, Ostermann N, Randl S, Yoon T, Mac Sweeney A, Cumin F, Lorthiois E, Rüdisser S, Erbel P, Maibaum J.
Vulpetti A, et al. Among authors: randl s.
ACS Med Chem Lett. 2018 Apr 24;9(5):490-495. doi: 10.1021/acsmedchemlett.8b00104. eCollection 2018 May 10.
ACS Med Chem Lett. 2018.
PMID: 29795765
Free PMC article.
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Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
Lorthiois E, Anderson K, Vulpetti A, Rogel O, Cumin F, Ostermann N, Steinbacher S, Mac Sweeney A, Delgado O, Liao SM, Randl S, Rüdisser S, Dussauge S, Fettis K, Kieffer L, de Erkenez A, Yang L, Hartwieg C, Argikar UA, La Bonte LR, Newton R, Kansara V, Flohr S, Hommel U, Jaffee B, Maibaum J.
Lorthiois E, et al. Among authors: randl s.
J Med Chem. 2017 Jul 13;60(13):5717-5735. doi: 10.1021/acs.jmedchem.7b00425. Epub 2017 Jun 30.
J Med Chem. 2017.
PMID: 28621538
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Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors.
Vulpetti A, Randl S, Rüdisser S, Ostermann N, Erbel P, Mac Sweeney A, Zoller T, Salem B, Gerhartz B, Cumin F, Hommel U, Dalvit C, Lorthiois E, Maibaum J.
Vulpetti A, et al. Among authors: randl s.
J Med Chem. 2017 Mar 9;60(5):1946-1958. doi: 10.1021/acs.jmedchem.6b01684. Epub 2017 Feb 20.
J Med Chem. 2017.
PMID: 28157311
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Small-molecule factor D inhibitors targeting the alternative complement pathway.
Maibaum J, Liao SM, Vulpetti A, Ostermann N, Randl S, Rüdisser S, Lorthiois E, Erbel P, Kinzel B, Kolb FA, Barbieri S, Wagner J, Durand C, Fettis K, Dussauge S, Hughes N, Delgado O, Hommel U, Gould T, Mac Sweeney A, Gerhartz B, Cumin F, Flohr S, Schubart A, Jaffee B, Harrison R, Risitano AM, Eder J, Anderson K.
Maibaum J, et al. Among authors: randl s.
Nat Chem Biol. 2016 Dec;12(12):1105-1110. doi: 10.1038/nchembio.2208. Epub 2016 Oct 24.
Nat Chem Biol. 2016.
PMID: 27775713
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