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Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential.
Coteron JM, Marco M, Esquivias J, Deng X, White KL, White J, Koltun M, El Mazouni F, Kokkonda S, Katneni K, Bhamidipati R, Shackleford DM, Angulo-Barturen I, Ferrer SB, Jiménez-Díaz MB, Gamo FJ, Goldsmith EJ, Charman WN, Bathurst I, Floyd D, Matthews D, Burrows JN, Rathod PK, Charman SA, Phillips MA. Coteron JM, et al. Among authors: rathod pk. J Med Chem. 2011 Aug 11;54(15):5540-61. doi: 10.1021/jm200592f. Epub 2011 Jul 14. J Med Chem. 2011. PMID: 21696174 Free PMC article.
Prized malaria drug target nailed.
Rathod PK, Phillips MA. Rathod PK, et al. Nat Struct Biol. 2003 May;10(5):316-8. doi: 10.1038/nsb0503-316. Nat Struct Biol. 2003. PMID: 12714998 No abstract available.
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.
Eastman RT, White J, Hucke O, Bauer K, Yokoyama K, Nallan L, Chakrabarti D, Verlinde CL, Gelb MH, Rathod PK, Van Voorhis WC. Eastman RT, et al. Among authors: rathod pk. J Biol Chem. 2005 Apr 8;280(14):13554-9. doi: 10.1074/jbc.M413556200. Epub 2005 Jan 20. J Biol Chem. 2005. PMID: 15661734 Free article.
122 results