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Treatment of obesity with celastrol.
Liu J, Lee J, Salazar Hernandez MA, Mazitschek R, Ozcan U. Liu J, et al. Among authors: salazar hernandez ma. Cell. 2015 May 21;161(5):999-1011. doi: 10.1016/j.cell.2015.05.011. Cell. 2015. PMID: 26000480 Free PMC article.
IL1R1 is required for celastrol's leptin-sensitization and antiobesity effects.
Feng X, Guan D, Auen T, Choi JW, Salazar Hernández MA, Lee J, Chun H, Faruk F, Kaplun E, Herbert Z, Copps KD, Ozcan U. Feng X, et al. Among authors: salazar hernandez ma. Nat Med. 2019 Apr;25(4):575-582. doi: 10.1038/s41591-019-0358-x. Epub 2019 Mar 4. Nat Med. 2019. PMID: 30833749 Free PMC article.
XBP1s Is an Anti-lipogenic Protein.
Herrema H, Zhou Y, Zhang D, Lee J, Salazar Hernandez MA, Shulman GI, Ozcan U. Herrema H, et al. Among authors: salazar hernandez ma. J Biol Chem. 2016 Aug 12;291(33):17394-404. doi: 10.1074/jbc.M116.728949. Epub 2016 Jun 20. J Biol Chem. 2016. PMID: 27325692 Free PMC article.
Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction.
Liu J, Ibi D, Taniguchi K, Lee J, Herrema H, Akosman B, Mucka P, Salazar Hernandez MA, Uyar MF, Park SW, Karin M, Ozcan U. Liu J, et al. Among authors: salazar hernandez ma. Cell. 2016 Nov 3;167(4):1052-1066.e18. doi: 10.1016/j.cell.2016.10.015. Cell. 2016. PMID: 27814504 Free PMC article.