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1945 2
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1947 1
1948 1
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1950 2
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1954 2
1955 6
1956 1
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1961 5
1962 4
1963 28
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1965 69
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2006 1020
2007 986
2008 1154
2009 1168
2010 1262
2011 1383
2012 1395
2013 1554
2014 1823
2015 1993
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The following term was not found in PubMed: Katzurin
Page 1
Did you mean sam azurin (14 results)?
The U6 snRNA m(6)A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.
Pendleton KE, Chen B, Liu K, Hunter OV, Xie Y, Tu BP, Conrad NK. Pendleton KE, et al. Cell. 2017 May 18;169(5):824-835.e14. doi: 10.1016/j.cell.2017.05.003. Cell. 2017. PMID: 28525753 Free PMC article.
Maintenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for a wide variety of biological processes. We demonstrate that the N(6)-adenosine methyltransferase METTL16 regulates expression of human MAT2A, which encodes the SAM synthetase …
Maintenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for a wide variety of biological processes. W …
Sam Domains in Multiple Diseases.
Vincenzi M, Mercurio FA, Leone M. Vincenzi M, et al. Curr Med Chem. 2020;27(3):450-476. doi: 10.2174/0929867325666181009114445. Curr Med Chem. 2020. PMID: 30306850 Review.
This study intends to collect state-of-the-art knowledge on the different modes by which Sam domains can favor disease onset and progression. METHODS: This review was build up by searching throughout the literature, for: a) the structural properties of Sam domains, …
This study intends to collect state-of-the-art knowledge on the different modes by which Sam domains can favor disease onset and prog …
The structure of the SAM/SAH-binding riboswitch.
Weickhmann AK, Keller H, Wurm JP, Strebitzer E, Juen MA, Kremser J, Weinberg Z, Kreutz C, Duchardt-Ferner E, Wöhnert J. Weickhmann AK, et al. Nucleic Acids Res. 2019 Mar 18;47(5):2654-2665. doi: 10.1093/nar/gky1283. Nucleic Acids Res. 2019. PMID: 30590743 Free PMC article.
S-adenosylmethionine (SAM) is a central metabolite since it is used as a methyl group donor in many different biochemical reactions. Many bacteria control intracellular SAM concentrations using riboswitch-based mechanisms. A number of structurally different riboswit …
S-adenosylmethionine (SAM) is a central metabolite since it is used as a methyl group donor in many different biochemical reactions. …
Radical SAM enzymes: Nature's choice for radical reactions.
Broderick JB, Broderick WE, Hoffman BM. Broderick JB, et al. FEBS Lett. 2023 Jan;597(1):92-101. doi: 10.1002/1873-3468.14519. Epub 2022 Oct 27. FEBS Lett. 2023. PMID: 36251330 Free PMC article. Review.
Enzymes that use a [4Fe-4S](1+) cluster plus S-adenosyl-l-methionine (SAM) to initiate radical reactions (radical SAM) form the largest enzyme superfamily, with over half a million members across the tree of life. ...The simplicity of SAM as a radical precurs …
Enzymes that use a [4Fe-4S](1+) cluster plus S-adenosyl-l-methionine (SAM) to initiate radical reactions (radical SAM) form th …
Diversity of the reaction mechanisms of SAM-dependent enzymes.
Sun Q, Huang M, Wei Y. Sun Q, et al. Acta Pharm Sin B. 2021 Mar;11(3):632-650. doi: 10.1016/j.apsb.2020.08.011. Epub 2020 Aug 26. Acta Pharm Sin B. 2021. PMID: 33777672 Free PMC article. Review.
Methyltransferases (MTases), a major group of SAM-dependent enzymes, catalyze methyl transfer from SAM to C, O, N, and S atoms in small-molecule secondary metabolites and macromolecules, including proteins and nucleic acids. ...Herein, we mainly describe the nonmeth …
Methyltransferases (MTases), a major group of SAM-dependent enzymes, catalyze methyl transfer from SAM to C, O, N, and S atoms …
Have You Seen SAM?
Fleming S, Tang R, Ferguson J, Kwok R, Jansen S. Fleming S, et al. EJVES Short Rep. 2018 Feb 6;38:8-11. doi: 10.1016/j.ejvssr.2017.12.001. eCollection 2018. EJVES Short Rep. 2018. PMID: 29780893 Free PMC article.
REPORT: A case is reported of a patient with SAM affecting the renal arteries bilaterally, where the diagnosis was made by excluding other inflammatory, immunological, and infectious mimickers. DISCUSSION: As SAM carries a significant mortality and morbidity from en …
REPORT: A case is reported of a patient with SAM affecting the renal arteries bilaterally, where the diagnosis was made by excluding …
Making and breaking carbon-carbon bonds in class C radical SAM methyltransferases.
Brimberry MA, Mathew L, Lanzilotta W. Brimberry MA, et al. J Inorg Biochem. 2022 Jan;226:111636. doi: 10.1016/j.jinorgbio.2021.111636. Epub 2021 Oct 22. J Inorg Biochem. 2022. PMID: 34717253 Free PMC article. Review.
At the heart of radical SAM catalysis is a highly reactive 5'-deoxyadenosyl radical intermediate (5'-dAdo) generated through reductive cleavage of SAM or nucleophilic attack of the unique iron of the [4Fe-4S](+) cluster on the 5' C atom of SAM. ...While remin …
At the heart of radical SAM catalysis is a highly reactive 5'-deoxyadenosyl radical intermediate (5'-dAdo) generated through reductiv …
S-Adenosylmethionine: more than just a methyl donor.
Lee YH, Ren D, Jeon B, Liu HW. Lee YH, et al. Nat Prod Rep. 2023 Sep 20;40(9):1521-1549. doi: 10.1039/d2np00086e. Nat Prod Rep. 2023. PMID: 36891755 Free PMC article. Review.
The reaction scope is further expanded as SAM itself can be modified prior to the group transfer such that a SAM-derived carboxymethyl or aminopropyl moiety can also be transferred. Moreover, the sulfonium cation in SAM has itself been found to be critical fo …
The reaction scope is further expanded as SAM itself can be modified prior to the group transfer such that a SAM-derived carbo …
Structure-based insights into recognition and regulation of SAM-sensing riboswitches.
Zheng L, Song Q, Xu X, Shen X, Li C, Li H, Chen H, Ren A. Zheng L, et al. Sci China Life Sci. 2023 Jan;66(1):31-50. doi: 10.1007/s11427-022-2188-7. Epub 2022 Nov 29. Sci China Life Sci. 2023. PMID: 36459353 Review.
SAM riboswitch is one of the most abundant riboswitches that bind to SAM with high affinity and selectivity, serving as regulatory modules in multiple metabolic pathways. To date, seven SAM-specific riboswitch classes that belong to four families, one SAM …
SAM riboswitch is one of the most abundant riboswitches that bind to SAM with high affinity and selectivity, serving as regula …
MetJ-Based Mutually Interfering SAM-ON/SAM-OFF Biosensors.
Watanabe T, Kimura Y, Umeno D. Watanabe T, et al. ACS Synth Biol. 2024 Feb 16;13(2):624-633. doi: 10.1021/acssynbio.3c00621. Epub 2024 Jan 29. ACS Synth Biol. 2024. PMID: 38286030
SAM is a corepressor of MetJ, which suppresses the MetJ promoter with an increasing cellular concentration of SAM (SAM-OFF sensor). ...By taking the ratio of SAM-ON/SAM-OFF signals and by resetting the default pool size of SAM, we could r …
SAM is a corepressor of MetJ, which suppresses the MetJ promoter with an increasing cellular concentration of SAM (SAM- …
40,161 results
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