Spiekermann K - Search Results

1

GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia.

Greif PA, Dufour A, Konstandin NP, Ksienzyk B, Zellmeier E, Tizazu B, Sturm J, Benthaus T, Herold T, Yaghmaie M, Dörge P, Hopfner KP, Hauser A, Graf A, Krebs S, Blum H, Kakadia PM, Schneider S, Hoster E, Schneider F, Stanulla M, Braess J, Sauerland MC, Berdel WE, Büchner T, Woermann BJ, Hiddemann W, Spiekermann K, Bohlander SK. Greif PA, et al. Among authors: spiekermann k. Blood. 2012 Jul 12;120(2):395-403. doi: 10.1182/blood-2012-01-403220. Epub 2012 May 30. Blood. 2012. PMID: 22649106 Free article. Clinical Trial.

2

Expression of granulocyte colony-stimulating factor- and granulocyte-macrophage colony-stimulating factor-associated signal transduction proteins of the JAK/STAT pathway in normal granulopoiesis and in blast cells of acute myelogenous leukemia.

Biethahn S, Alves F, Wilde S, Hiddemann W, Spiekermann K. Biethahn S, et al. Among authors: spiekermann k. Exp Hematol. 1999 May;27(5):885-94. doi: 10.1016/s0301-472x(99)00017-x. Exp Hematol. 1999. PMID: 10340405 Free article.

3

Constitutive activation of STAT transcription factors in acute myelogenous leukemia.

Spiekermann K, Biethahn S, Wilde S, Hiddemann W, Alves F. Spiekermann K, et al. Eur J Haematol. 2001 Aug;67(2):63-71. Eur J Haematol. 2001. PMID: 11722592

4

Constitutive activation of STAT3 and STAT5 is induced by leukemic fusion proteins with protein tyrosine kinase activity and is sufficient for transformation of hematopoietic precursor cells.

Spiekermann K, Pau M, Schwab R, Schmieja K, Franzrahe S, Hiddemann W. Spiekermann K, et al. Exp Hematol. 2002 Mar;30(3):262-71. doi: 10.1016/s0301-472x(01)00787-1. Exp Hematol. 2002. PMID: 11882364 Free article.

5

The protein tyrosine kinase inhibitor SU5614 inhibits VEGF-induced endothelial cell sprouting and induces growth arrest and apoptosis by inhibition of c-kit in AML cells.

Spiekermann K, Faber F, Voswinckel R, Hiddemann W. Spiekermann K, et al. Exp Hematol. 2002 Jul;30(7):767-73. doi: 10.1016/s0301-472x(02)00837-8. Exp Hematol. 2002. PMID: 12135675 Free article.

6

A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia.

Spiekermann K, Bagrintseva K, Schoch C, Haferlach T, Hiddemann W, Schnittger S. Spiekermann K, et al. Blood. 2002 Nov 1;100(9):3423-5. doi: 10.1182/blood-2002-03-0953. Blood. 2002. PMID: 12384447 Free article.

7

The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3.

Spiekermann K, Dirschinger RJ, Schwab R, Bagrintseva K, Faber F, Buske C, Schnittger S, Kelly LM, Gilliland DG, Hiddemann W. Spiekermann K, et al. Blood. 2003 Feb 15;101(4):1494-504. doi: 10.1182/blood-2002-04-1045. Epub 2002 Oct 24. Blood. 2003. PMID: 12406902 Free article.

8

Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells.

Spiekermann K, Bagrintseva K, Schwab R, Schmieja K, Hiddemann W. Spiekermann K, et al. Clin Cancer Res. 2003 Jun;9(6):2140-50. Clin Cancer Res. 2003. PMID: 12796379

9

Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells.

Bagrintseva K, Schwab R, Kohl TM, Schnittger S, Eichenlaub S, Ellwart JW, Hiddemann W, Spiekermann K. Bagrintseva K, et al. Among authors: spiekermann k. Blood. 2004 Mar 15;103(6):2266-75. doi: 10.1182/blood-2003-05-1653. Epub 2003 Nov 6. Blood. 2004. PMID: 14604974 Free article.

10

KIT exon 8 mutations associated with core-binding factor (CBF)-acute myeloid leukemia (AML) cause hyperactivation of the receptor in response to stem cell factor.

Kohl TM, Schnittger S, Ellwart JW, Hiddemann W, Spiekermann K. Kohl TM, et al. Among authors: spiekermann k. Blood. 2005 Apr 15;105(8):3319-21. doi: 10.1182/blood-2004-06-2068. Epub 2004 Dec 23. Blood. 2005. PMID: 15618474 Free article.

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