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CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans.
Li Y, Finkbeiner S, Ganner A, Gerber J, Klein M, Grafe M, Kandzia J, Thien A, Thedieck K, Breves G, Jank T, Baumeister R, Walz G, Neumann-Haefelin E. Li Y, et al. Among authors: thedieck k. Oncotarget. 2018 Jan 6;9(11):9581-9595. doi: 10.18632/oncotarget.24039. eCollection 2018 Feb 9. Oncotarget. 2018. PMID: 29515755 Free PMC article.
Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells.
Thedieck K, Holzwarth B, Prentzell MT, Boehlke C, Kläsener K, Ruf S, Sonntag AG, Maerz L, Grellscheid SN, Kremmer E, Nitschke R, Kuehn EW, Jonker JW, Groen AK, Reth M, Hall MN, Baumeister R. Thedieck K, et al. Cell. 2013 Aug 15;154(4):859-74. doi: 10.1016/j.cell.2013.07.031. Cell. 2013. PMID: 23953116 Free article.
TSC1 activates TGF-β-Smad2/3 signaling in growth arrest and epithelial-to-mesenchymal transition.
Thien A, Prentzell MT, Holzwarth B, Kläsener K, Kuper I, Boehlke C, Sonntag AG, Ruf S, Maerz L, Nitschke R, Grellscheid SN, Reth M, Walz G, Baumeister R, Neumann-Haefelin E, Thedieck K. Thien A, et al. Among authors: thedieck k. Dev Cell. 2015 Mar 9;32(5):617-30. doi: 10.1016/j.devcel.2015.01.026. Epub 2015 Feb 26. Dev Cell. 2015. PMID: 25727005 Free article.
PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy.
Ruf S, Heberle AM, Langelaar-Makkinje M, Gelino S, Wilkinson D, Gerbeth C, Schwarz JJ, Holzwarth B, Warscheid B, Meisinger C, van Vugt MA, Baumeister R, Hansen M, Thedieck K. Ruf S, et al. Among authors: thedieck k. Autophagy. 2017 Mar 4;13(3):486-505. doi: 10.1080/15548627.2016.1263781. Epub 2017 Jan 19. Autophagy. 2017. PMID: 28102733 Free PMC article.
G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.
Prentzell MT, Rehbein U, Cadena Sandoval M, De Meulemeester AS, Baumeister R, Brohée L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G; Genomics England Research Consortium; de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Ramos Pittol JM, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K. Prentzell MT, et al. Among authors: thedieck k. Cell. 2021 Feb 4;184(3):655-674.e27. doi: 10.1016/j.cell.2020.12.024. Epub 2021 Jan 25. Cell. 2021. PMID: 33497611 Free PMC article.
Finding new edges: systems approaches to MTOR signaling.
Heberle AM, Rehbein U, Rodríguez Peiris M, Thedieck K. Heberle AM, et al. Among authors: thedieck k. Biochem Soc Trans. 2021 Feb 26;49(1):41-54. doi: 10.1042/BST20190730. Biochem Soc Trans. 2021. PMID: 33544134 Free PMC article. Review.
The TSC Complex-mTORC1 Axis: From Lysosomes to Stress Granules and Back.
Rehbein U, Prentzell MT, Cadena Sandoval M, Heberle AM, Henske EP, Opitz CA, Thedieck K. Rehbein U, et al. Among authors: thedieck k. Front Cell Dev Biol. 2021 Oct 29;9:751892. doi: 10.3389/fcell.2021.751892. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34778262 Free PMC article. Review.
Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity.
Abdellatif M, Trummer-Herbst V, Heberle AM, Humnig A, Pendl T, Durand S, Cerrato G, Hofer SJ, Islam M, Voglhuber J, Ramos Pittol JM, Kepp O, Hoefler G, Schmidt A, Rainer PP, Scherr D, von Lewinski D, Bisping E, McMullen JR, Diwan A, Eisenberg T, Madeo F, Thedieck K, Kroemer G, Sedej S. Abdellatif M, et al. Among authors: thedieck k. Circulation. 2022 Jun 21;145(25):1853-1866. doi: 10.1161/CIRCULATIONAHA.122.059863. Epub 2022 May 26. Circulation. 2022. PMID: 35616058 Free PMC article.
43 results