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The TRIOBP Isoforms and Their Distinct Roles in Actin Stabilization, Deafness, Mental Illness, and Cancer.
Zaharija B, Samardžija B, Bradshaw NJ. Zaharija B, et al. Molecules. 2020 Oct 27;25(21):4967. doi: 10.3390/molecules25214967. Molecules. 2020. PMID: 33121024 Free PMC article. Review.
Splicing of the TRIOBP gene is complex, with the two most studied TRIOBP protein isoforms sharing no overlapping amino acid sequence with each other. ...In contrast, TRIOBP-4 is an entirely disordered protein with a highly specialized expression pattern. ...
Splicing of the TRIOBP gene is complex, with the two most studied TRIOBP protein isoforms sharing no overlapping amino acid se …
ANKRD24 organizes TRIOBP to reinforce stereocilia insertion points.
Krey JF, Liu C, Belyantseva IA, Bateschell M, Dumont RA, Goldsmith J, Chatterjee P, Morrill RS, Fedorov LM, Foster S, Kim J, Nuttall AL, Jones SM, Choi D, Friedman TB, Ricci AJ, Zhao B, Barr-Gillespie PG. Krey JF, et al. J Cell Biol. 2022 Apr 4;221(4):e202109134. doi: 10.1083/jcb.202109134. Epub 2022 Feb 17. J Cell Biol. 2022. PMID: 35175278 Free PMC article.
Annular ANKRD24 continues into the lower rootlet, where it surrounds and binds TRIOBP-5, which itself bundles rootlet F-actin. TRIOBP-5 is mislocalized in Ankrd24KO/KO hair cells, and ANKRD24 no longer localizes with rootlets in mice lacking TRIOBP-5; exogeno …
Annular ANKRD24 continues into the lower rootlet, where it surrounds and binds TRIOBP-5, which itself bundles rootlet F-actin. TRI …
TRIOBP-5 sculpts stereocilia rootlets and stiffens supporting cells enabling hearing.
Katsuno T, Belyantseva IA, Cartagena-Rivera AX, Ohta K, Crump SM, Petralia RS, Ono K, Tona R, Imtiaz A, Rehman A, Kiyonari H, Kaneko M, Wang YX, Abe T, Ikeya M, Fenollar-Ferrer C, Riordan GP, Wilson EA, Fitzgerald TS, Segawa K, Omori K, Ito J, Frolenkov GI, Friedman TB, Kitajiri SI. Katsuno T, et al. JCI Insight. 2019 Jun 20;4(12):e128561. doi: 10.1172/jci.insight.128561. eCollection 2019 Jun 20. JCI Insight. 2019. PMID: 31217345 Free PMC article.
Mutations ablating human and mouse TRIOBP-4 and TRIOBP-5 isoforms are associated with profound deafness, as inner ear mechanosensory hair cells degenerate after stereocilia rootlets fail to develop. However, the mechanisms regulating formation of stereocilia rootlet …
Mutations ablating human and mouse TRIOBP-4 and TRIOBP-5 isoforms are associated with profound deafness, as inner ear mechanos …
TRIOBP-1 Protein Aggregation Exists in Both Major Depressive Disorder and Schizophrenia, and Can Occur through Two Distinct Regions of the Protein.
Zaharija B, Odorčić M, Hart A, Samardžija B, Marreiros R, Prikulis I, Juković M, Hyde TM, Kleinman JE, Korth C, Bradshaw NJ. Zaharija B, et al. Int J Mol Sci. 2022 Sep 21;23(19):11048. doi: 10.3390/ijms231911048. Int J Mol Sci. 2022. PMID: 36232351 Free PMC article.
In this way, it was possible to narrow down the aggregation-critical region of TRIOBP-1 to just 8 amino acids (333-340 of the 652 amino acid-long TRIOBP-1). ...The presence of insoluble TRIOBP-1 in brain samples from patients, combined with insight into the m …
In this way, it was possible to narrow down the aggregation-critical region of TRIOBP-1 to just 8 amino acids (333-340 of the 652 ami …
Genetic Hearing Loss Overview.
Shearer AE, Hildebrand MS, Schaefer AM, Smith RJH. Shearer AE, et al. 1999 Feb 14 [updated 2023 Sep 28]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 1999 Feb 14 [updated 2023 Sep 28]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301607 Free Books & Documents. Review.
TRIOBP modulates beta-catenin signaling by regulation of miR-29b in idiopathic pulmonary fibrosis.
Wang L, Zhao W, Xia C, Ma S, Li Z, Wang N, Ding L, Wang Y, Cheng L, Liu H, Yang J, Li Y, Rosas I, Yu G. Wang L, et al. Cell Mol Life Sci. 2023 Dec 29;81(1):13. doi: 10.1007/s00018-023-05080-4. Cell Mol Life Sci. 2023. PMID: 38157020 Free PMC article.
Recently, our study identified that F-Actin Binding Protein (TRIOBP) is one of the target genes of miR-29b and found that deficiency of TRIOBP increases resistance to lung fibrosis in vivo. TRIOBP knockdown inhibited the proliferation of epithelial cells and …
Recently, our study identified that F-Actin Binding Protein (TRIOBP) is one of the target genes of miR-29b and found that deficiency …
A novel mutation in TRIOBP gene leading to congenital deafness in a Chinese family.
Zhou B, Yu L, Wang Y, Shang W, Xie Y, Wang X, Han F. Zhou B, et al. BMC Med Genet. 2020 Jun 1;21(1):121. doi: 10.1186/s12881-020-01055-5. BMC Med Genet. 2020. PMID: 32487028 Free PMC article.
BACKGROUND: The autosomal recessive non-syndromic deafness DFNB28 is characterized by prelingual sensorineural hearing loss. The disease is related with mutations in TRIOBP (Trio- and F-actin-Binding Protein) gene, which has three transcripts referred to as TRIOBP-5 …
BACKGROUND: The autosomal recessive non-syndromic deafness DFNB28 is characterized by prelingual sensorineural hearing loss. The disease is …
Emerging roles of TRIO and F-actin-binding protein in human diseases.
Park S, Lee H, Kim M, Park J, Kim SH, Park J. Park S, et al. Cell Commun Signal. 2018 Jun 11;16(1):29. doi: 10.1186/s12964-018-0237-y. Cell Commun Signal. 2018. PMID: 29890989 Free PMC article. Review.
TRIOBP-1 is important for regulating F-actin filament reorganization. ...TRIOBP variant-5 contains all exons. Earlier studies indicated that TRIOBP-4/5 mutation is a pivotal element of autosomal recessive nonsyndromic hearing loss. ...
TRIOBP-1 is important for regulating F-actin filament reorganization. ...TRIOBP variant-5 contains all exons. Earlier studies …
Elucidation of repeat motifs R1- and R2-related TRIOBP variants in autosomal recessive nonsyndromic hearing loss DFNB28 among indigenous South African individuals.
Kabahuma RI, Schubert WD, Labuschagne C, Yan D, Pepper MS, Liu XZ. Kabahuma RI, et al. Mol Genet Genomic Med. 2022 Oct;10(10):e2015. doi: 10.1002/mgg3.2015. Epub 2022 Aug 27. Mol Genet Genomic Med. 2022. PMID: 36029164 Free PMC article.
BACKGROUND: DFNB28, a recessively inherited nonsyndromic form of deafness in humans, is caused by mutations in the TRIOBP gene (MIM #609761) on chromosome 22q13. Its protein TRIOBP helps to tightly bundle F-actin filaments, forming a rootlet that penetrates through …
BACKGROUND: DFNB28, a recessively inherited nonsyndromic form of deafness in humans, is caused by mutations in the TRIOBP gene (MIM # …
Aggregation of the protein TRIOBP-1 and its potential relevance to schizophrenia.
Bradshaw NJ, Bader V, Prikulis I, Lueking A, Müllner S, Korth C. Bradshaw NJ, et al. PLoS One. 2014 Oct 21;9(10):e111196. doi: 10.1371/journal.pone.0111196. eCollection 2014. PLoS One. 2014. PMID: 25333879 Free PMC article.
The 3' splice variant TRIOBP-1 is found to be the antibody substrate and has a high aggregation propensity when over-expressed in neuroblastoma cells, while the major 5' splice variant, TRIOBP-4, does not. Endogenous TRIOBP-1 can also spontaneously aggregate, …
The 3' splice variant TRIOBP-1 is found to be the antibody substrate and has a high aggregation propensity when over-expressed in neu …
86 results