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Tspan2: a tetraspanin protein involved in oligodendrogenesis and cancer metastasis.
Yaseen IH, Monk PN, Partridge LJ. Yaseen IH, et al. Biochem Soc Trans. 2017 Apr 15;45(2):465-475. doi: 10.1042/BST20160022. Biochem Soc Trans. 2017. PMID: 28408487 Free PMC article. Review.
Furthermore, in human lung cancer, Tspan2 could be involved in the progression of the tumour metastasis by modulating cancer cell motility and invasion functions. In this review, we discuss the available evidence for the potential role of Tspan2 and introduce possib …
Furthermore, in human lung cancer, Tspan2 could be involved in the progression of the tumour metastasis by modulating cancer cell mot …
The role of tetraspanins pan-cancer.
Huang R, Sun H, Lin R, Zhang J, Yin H, Xian S, Li M, Wang S, Li Z, Qiao Y, Jiang M, Yan P, Meng T, Huang Z. Huang R, et al. iScience. 2022 Jul 19;25(8):104777. doi: 10.1016/j.isci.2022.104777. eCollection 2022 Aug 19. iScience. 2022. PMID: 35992081 Free PMC article.
In this work, we analyzed TSPAN1, TSPAN10, TSPAN11, TSPAN12, TSPAN13, TSPAN14, TSPAN15, TSPAN16, TSPAN17, TSPAN18, TSPAN18-AS1, TSPAN19, TSPAN2, TSPAN3, TSPAN31, TSPAN32, TSPAN33, TSPAN4, TSPAN5, TSPAN6, TSPAN7, TSPAN8, TSPAN9, TSPAN9-IT1 (24 TSPAN family genes) in relatio …
In this work, we analyzed TSPAN1, TSPAN10, TSPAN11, TSPAN12, TSPAN13, TSPAN14, TSPAN15, TSPAN16, TSPAN17, TSPAN18, TSPAN18-AS1, TSPAN19, …
TSPAN2 is involved in cell invasion and motility during lung cancer progression.
Otsubo C, Otomo R, Miyazaki M, Matsushima-Hibiya Y, Kohno T, Iwakawa R, Takeshita F, Okayama H, Ichikawa H, Saya H, Kiyono T, Ochiya T, Tashiro F, Nakagama H, Yokota J, Enari M. Otsubo C, et al. Cell Rep. 2014 Apr 24;7(2):527-538. doi: 10.1016/j.celrep.2014.03.027. Epub 2014 Apr 13. Cell Rep. 2014. PMID: 24726368 Free article.
TSPAN2 is highly expressed in p53-mutated lung cancer cells, and high expression of TSPAN2 is associated with the poor prognosis of lung adenocarinomas. TSPAN2 knockdown suppresses metastasis to the lungs and liver, enabling prolonged survival. ...
TSPAN2 is highly expressed in p53-mutated lung cancer cells, and high expression of TSPAN2 is associated with the poor prognos …
Transmigration of Tetraspanin 2 (Tspan2) siRNA Via Microglia Derived Exosomes across the Blood Brain Barrier Modifies the Production of Immune Mediators by Microglia Cells.
Reynolds JL, Mahajan SD. Reynolds JL, et al. J Neuroimmune Pharmacol. 2020 Sep;15(3):554-563. doi: 10.1007/s11481-019-09895-6. Epub 2019 Dec 10. J Neuroimmune Pharmacol. 2020. PMID: 31823250 Free PMC article.
A dose dependent (5-40 pmol) increase in Cy5-Tspan2 uptake with a corresponding decrease in gene expression for Tspan2 occurred in HTHU-HIV microglia. ...Graphical Abstract Microglia-derived exosomes loaded with Tspan2 siRNA transmigrate across the BBB and kn …
A dose dependent (5-40 pmol) increase in Cy5-Tspan2 uptake with a corresponding decrease in gene expression for Tspan2 occurre …
Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression.
Gao P, Lyu Q, Ghanam AR, Lazzarotto CR, Newby GA, Zhang W, Choi M, Slivano OJ, Holden K, Walker JA 2nd, Kadina AP, Munroe RJ, Abratte CM, Schimenti JC, Liu DR, Tsai SQ, Long X, Miano JM. Gao P, et al. Genome Biol. 2021 Mar 16;22(1):83. doi: 10.1186/s13059-021-02304-3. Genome Biol. 2021. PMID: 33722289 Free PMC article.
Here, a comparative analysis of CRISPR-mediated homology-directed repair (HDR) versus the recently reported prime editing 2 (PE2) system was carried out in mice over a TFBS called a CArG box in the Tspan2 promoter. RESULTS: Quantitative RT-PCR showed loss of Tspan2 …
Here, a comparative analysis of CRISPR-mediated homology-directed repair (HDR) versus the recently reported prime editing 2 (PE2) system was …
Selective expression of TSPAN2 in vascular smooth muscle is independently regulated by TGF-beta1/SMAD and myocardin/serum response factor.
Zhao J, Wu W, Zhang W, Lu YW, Tou E, Ye J, Gao P, Jourd'heuil D, Singer HA, Wu M, Long X. Zhao J, et al. FASEB J. 2017 Jun;31(6):2576-2591. doi: 10.1096/fj.201601021R. Epub 2017 Mar 3. FASEB J. 2017. PMID: 28258189 Free PMC article.
We also found that TSPAN2 is highly expressed in smooth muscle-enriched tissues and down-regulated in in vitro models of VSMC phenotypic modulation. ...In vitro functional studies showed that TSPAN2 suppresses VSMC proliferation and migration. Luciferase reporter an …
We also found that TSPAN2 is highly expressed in smooth muscle-enriched tissues and down-regulated in in vitro models of VSMC phenoty …
Involvement of the Tetraspanin 2 (TSPAN2) Gene in Migraine: A Case-Control Study in Han Chinese.
Fang J, Yuan X, An X, Qu H, Wang C, Hong G, Zheng L, Yi K, Chen S, Wang X, Ma Q. Fang J, et al. Front Neurol. 2018 Sep 11;9:714. doi: 10.3389/fneur.2018.00714. eCollection 2018. Front Neurol. 2018. PMID: 30258394 Free PMC article.
A case-control study (425 patients with migraine and 425 healthy controls) in a Chinese Han population was performed to evaluate the associations between migraine and TSPAN2 via a genotype-phenotype analysis between TSPAN2 and clinical symptoms. ...Considering that …
A case-control study (425 patients with migraine and 425 healthy controls) in a Chinese Han population was performed to evaluate the associa …
The immunomodulatory oligodendrocyte.
Zeis T, Enz L, Schaeren-Wiemers N. Zeis T, et al. Brain Res. 2016 Jun 15;1641(Pt A):139-148. doi: 10.1016/j.brainres.2015.09.021. Epub 2015 Sep 28. Brain Res. 2016. PMID: 26423932 Review.
C1s, C2 and C3, C1R), complement regulatory molecules (e.g. CD46, CD55, CD59), tetraspanins (e.g. TSPAN2), neuroimmune regulatory proteins (e.g. CD200, CD47) as well as extracellular matrix proteins (e.g. ...
C1s, C2 and C3, C1R), complement regulatory molecules (e.g. CD46, CD55, CD59), tetraspanins (e.g. TSPAN2), neuroimmune regulatory pro …
Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles.
Zheng W, Rädler J, Sork H, Niu Z, Roudi S, Bost JP, Görgens A, Zhao Y, Mamand DR, Liang X, Wiklander OPB, Lehto T, Gupta D, Nordin JZ, El Andaloussi S. Zheng W, et al. Nat Commun. 2023 Aug 7;14(1):4734. doi: 10.1038/s41467-023-40453-0. Nat Commun. 2023. PMID: 37550290 Free PMC article.
We identify 24 proteins with conserved EV-sorting abilities across five types of producer cells. TSPAN2 and TSPAN3 emerge as lead candidates and outperform the well-studied CD63 scaffold. ...
We identify 24 proteins with conserved EV-sorting abilities across five types of producer cells. TSPAN2 and TSPAN3 emerge as lead can …
Specific tetraspanin functions.
Hemler ME. Hemler ME. J Cell Biol. 2001 Dec 24;155(7):1103-7. doi: 10.1083/jcb.200108061. Epub 2001 Dec 24. J Cell Biol. 2001. PMID: 11756464 Free PMC article. Review.
51 results