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2001 1
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2012 4
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Page 1
Transcriptomic Association Analysis of the Metabolic Mechanism of Sulfamethoxazole in Channel Catfish (Ictalurus punctatus).
Du X, Sun R, Zhang L, Liu Y, Ai X. Du X, et al. Animals (Basel). 2024 Mar 30;14(7):1059. doi: 10.3390/ani14071059. Animals (Basel). 2024. PMID: 38612297 Free PMC article.
Also, UDP- glucuronosyltransferase (ugt), which is associated with glucuronidation, and UDP-glucuronosyltransferase 2C1-like (ugt2a1) showed significant upregulation. Carboxylesterase 5A-like (ces3), which promotes fatty acyl and cholesteryl ester metabolism, and the gluta …
Also, UDP- glucuronosyltransferase (ugt), which is associated with glucuronidation, and UDP-glucuronosyltransferase 2C1-like (ugt2a1) …
Glucuronidation Pathways of 5- and 7-Hydroxypropranolol: Determination of Glucuronide Structures and Enzyme Selectivity.
Yang F, Wenzel M, Bureik M, Parr MK. Yang F, et al. Molecules. 2023 Nov 26;28(23):7783. doi: 10.3390/molecules28237783. Molecules. 2023. PMID: 38067513 Free PMC article.
Among the 19 UGT enzymes examined, UGT1A1, UGT1A3, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2A1, and UGT2A2 were found to be involved in the glucuronidation of 5-OHP. ...
Among the 19 UGT enzymes examined, UGT1A1, UGT1A3, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2A1, and UGT2A2 were found to be involved in t …
Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol.
Yang F, Sharma SS, Bureik M, Parr MK. Yang F, et al. Curr Issues Mol Biol. 2023 Aug 26;45(9):7130-7146. doi: 10.3390/cimb45090451. Curr Issues Mol Biol. 2023. PMID: 37754235 Free PMC article.
In this study, the functional interactions of human CYP2D6 with four human UGTs (UGT1A7, UGT1A8, UGT1A9, and UGT2A1) were investigated using our previously established co-expression model system in the fission yeast Schizosaccharomyces pombe. ...Co-expression of either UGT …
In this study, the functional interactions of human CYP2D6 with four human UGTs (UGT1A7, UGT1A8, UGT1A9, and UGT2A1) were investigate …
Integrated clinical genomic analysis reveals xenobiotic metabolic genes are downregulated in meningiomas of current smokers.
Khan AB, Patel R, McDonald MF, Goethe E, English C, Gadot R, Shetty A, Nouri SH, Harmanci AO, Harmanci AS, Klisch TJ, Patel AJ. Khan AB, et al. J Neurooncol. 2023 Jun;163(2):397-405. doi: 10.1007/s11060-023-04359-7. Epub 2023 Jun 15. J Neurooncol. 2023. PMID: 37318677
Mutational signature from current and past smokers showed disrupted DNA mismatch repair (cosine-similarity = 0.759 and 0.783). DEG analysis revealed the xenobiotic metabolic genes UGT2A1 and UGT2A2 were both significantly downregulated in current smokers compared to past ( …
Mutational signature from current and past smokers showed disrupted DNA mismatch repair (cosine-similarity = 0.759 and 0.783). DEG analysis …
RNA Sequencing (RNA-Seq) Analysis Reveals Liver Lipid Metabolism Divergent Adaptive Response to Low- and High-Salinity Stress in Spotted Scat (Scatophagus argus).
Chen J, Cai B, Tian C, Jiang D, Shi H, Huang Y, Zhu C, Li G, Deng S. Chen J, et al. Animals (Basel). 2023 Apr 28;13(9):1503. doi: 10.3390/ani13091503. Animals (Basel). 2023. PMID: 37174540 Free PMC article.
The genes of steroid biosynthesis (sqle, dhcr7, and cyp51a1), steroid hormone biosynthesis (ugt2a1, ugt2a2, ugt2b20, and ugt2b31), and glycerophospholipid metabolism (cept1, pla2g4a, and ptdss2) were significantly down-regulated in the LS vs. ...
The genes of steroid biosynthesis (sqle, dhcr7, and cyp51a1), steroid hormone biosynthesis (ugt2a1, ugt2a2, ugt2b20, and ugt2b31), an …
A genome-wide association study identifies a novel association between SDC3 and apparent treatment-resistant hypertension.
Xiao X, Li R, Wu C, Yan Y, Yuan M, Cui B, Zhang Y, Zhang C, Zhang X, Zhang W, Hui R, Wang Y. Xiao X, et al. BMC Med. 2022 Nov 30;20(1):463. doi: 10.1186/s12916-022-02665-x. BMC Med. 2022. PMID: 36447229 Free PMC article.
RESULTS: The GWAS in first cohort revealed four suggestive loci (1p35, 4q13.2-21.1, 5q22-23.2, and 15q11.1-q12) represented by 23 SNPs. The 23 significant SNPs were in or near LAPTM5, SDC3, UGT2A1, FTMT, and NIPA1. eQTL analysis uncovered 14 SNPs in 1p35 locus all had same …
RESULTS: The GWAS in first cohort revealed four suggestive loci (1p35, 4q13.2-21.1, 5q22-23.2, and 15q11.1-q12) represented by 23 SNPs. The …
Complete Reaction Phenotyping of Propranolol and 4-Hydroxypropranolol with the 19 Enzymes of the Human UGT1 and UGT2 Families.
Yang F, Liu S, Wolber G, Bureik M, Parr MK. Yang F, et al. Int J Mol Sci. 2022 Jul 5;23(13):7476. doi: 10.3390/ijms23137476. Int J Mol Sci. 2022. PMID: 35806479 Free PMC article.
In the present study, glucuronidation of propranolol and its equipotent phase I metabolite 4-hydroxypropranolol by all 19 members of the human UGT1 and UGT2 families was monitored. UGT1A7, UGT1A9, UGT1A10 and UGT2A1 were found to glucuronidate propranolol, with UGT1A7, UGT …
In the present study, glucuronidation of propranolol and its equipotent phase I metabolite 4-hydroxypropranolol by all 19 members of the hum …
A Prognostic and Carboplatin Response Predictive Model in Ovarian Cancer: A Mono-Institutional Retrospective Study Based on Clinics and Pharmacogenomics.
Staropoli N, Arbitrio M, Salvino A, Scionti F, Ciliberto D, Ingargiola R, Labanca C, Agapito G, Iuliano E, Barbieri V, Cucè M, Zuccalà V, Cannataro M, Tassone P, Tagliaferri P. Staropoli N, et al. Biomedicines. 2022 May 23;10(5):1210. doi: 10.3390/biomedicines10051210. Biomedicines. 2022. PMID: 35625946 Free PMC article.
Among prognostic polymorphisms, we found a potential role of UGT2A1 both as a predictor of platinum-response (p = 0.01) and as prognostic of survival (p = 0.05). Finally, we identified 24 SNPs related to OS. UGT2A1 correlates to an "inflammatory-score" and retains a …
Among prognostic polymorphisms, we found a potential role of UGT2A1 both as a predictor of platinum-response (p = 0.01) and as progno …
61 results