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Prognostic potential of whole exome sequencing in the clinical management of metachronous colorectal cancer liver metastases.
Heczko L, Hlaváč V, Holý P, Dvořák P, Liška V, Vyčítal O, Fiala O, Souček P. Heczko L, et al. Cancer Cell Int. 2023 Nov 26;23(1):295. doi: 10.1186/s12935-023-03135-x. Cancer Cell Int. 2023. PMID: 38008721 Free PMC article.
BACKGROUND: Colorectal cancer is a highly prevalent and deadly. The most common metastatic site is the liver. ...CONCLUSIONS: The results encourage further molecular profiling for personalized treatment of colorectal cancer liver metastases discerning metachronous f …
BACKGROUND: Colorectal cancer is a highly prevalent and deadly. The most common metastatic site is the liver. ...CONCLUSIONS: The res …
The sodium leak channel, NALCN, in health and disease.
Cochet-Bissuel M, Lory P, Monteil A. Cochet-Bissuel M, et al. Front Cell Neurosci. 2014 May 20;8:132. doi: 10.3389/fncel.2014.00132. eCollection 2014. Front Cell Neurosci. 2014. PMID: 24904279 Free PMC article. Review.
In addition, genes encoding NALCN, NLF- 1, UNC-79, and UNC-80 proteins may be susceptibility loci for several diseases including bipolar disorder, schizophrenia, Alzheimer's disease, autism, epilepsy, alcoholism, cardiac diseases and cancer. Although the physiological role …
In addition, genes encoding NALCN, NLF- 1, UNC-79, and UNC-80 proteins may be susceptibility loci for several diseases including bipolar dis …
Identification of novel therapeutic target genes and pathway in pancreatic cancer by integrative analysis.
Hu B, Shi C, Jiang HX, Qin SY. Hu B, et al. Medicine (Baltimore). 2017 Oct;96(42):e8261. doi: 10.1097/MD.0000000000008261. Medicine (Baltimore). 2017. PMID: 29049217 Free PMC article.
BACKGROUND: Gene alterations are crucial to the molecular pathogenesis of pancreatic cancer. The present study was designed to identify the potential candidate genes in the pancreatic carcinogenesis. METHODS: Gene Expression Omnibus database (GEO) datasets of pancreatic …
BACKGROUND: Gene alterations are crucial to the molecular pathogenesis of pancreatic cancer. The present study was designed to identi …
Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma.
Agelopoulos K, Richter GH, Schmidt E, Dirksen U, von Heyking K, Moser B, Klein HU, Kontny U, Dugas M, Poos K, Korsching E, Buch T, Weckesser M, Schulze I, Besoke R, Witten A, Stoll M, Köhler G, Hartmann W, Wardelmann E, Rossig C, Baumhoer D, Jürgens H, Burdach S, Berdel WE, Müller-Tidow C. Agelopoulos K, et al. Clin Cancer Res. 2015 Nov 1;21(21):4935-46. doi: 10.1158/1078-0432.CCR-14-2744. Epub 2015 Jul 15. Clin Cancer Res. 2015. PMID: 26179511 Free article.
PURPOSE: A low mutation rate seems to be a general feature of pediatric cancers, in particular in oncofusion gene-driven tumors. Genetically, Ewing sarcoma is defined by balanced chromosomal EWS/ETS translocations, which give rise to oncogenic chimeric proteins (EWS-ETS). …
PURPOSE: A low mutation rate seems to be a general feature of pediatric cancers, in particular in oncofusion gene-driven tumors. Gene …