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Page 1
USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer.
Xie H, Zhou J, Liu X, Xu Y, Hepperla AJ, Simon JM, Wang T, Yao H, Liao C, Baldwin AS, Gong K, Zhang Q. Xie H, et al. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2119854119. doi: 10.1073/pnas.2119854119. Epub 2022 Aug 29. Proc Natl Acad Sci U S A. 2022. PMID: 36037364 Free PMC article.
As a result, USP13 promoted ZHX2 protein stability in an enzymatically dependent manner, and depletion of USP13 led to ZHX2 down-regulation in ccRCC. ...Our findings support that USP13 may be a key effector in ccRCC tumorigenesis....
As a result, USP13 promoted ZHX2 protein stability in an enzymatically dependent manner, and depletion of USP13 led to ZHX2 do …
USP13 promotes breast cancer metastasis through FBXL14-induced Twist1 ubiquitination.
Zhao B, Huo W, Yu X, Shi X, Lv L, Yang Y, Kang J, Li S, Wu H. Zhao B, et al. Cell Oncol (Dordr). 2023 Jun;46(3):717-733. doi: 10.1007/s13402-023-00779-9. Epub 2023 Feb 3. Cell Oncol (Dordr). 2023. PMID: 36732432 Free PMC article.
We found that the effect of USP13 in promoting the migration and invasion capacities of breast cancer cells can at least partly be achieved through its regulation of Twist1, while Twist1 can inhibit the transcriptional activity of USP13. CONCLUSIONS: Our data …
We found that the effect of USP13 in promoting the migration and invasion capacities of breast cancer cells can at least partl …
The deubiquitinase (DUB) USP13 promotes Mcl-1 stabilisation in cervical cancer.
Morgan EL, Patterson MR, Barba-Moreno D, Scarth JA, Wilson A, Macdonald A. Morgan EL, et al. Oncogene. 2021 Mar;40(11):2112-2129. doi: 10.1038/s41388-021-01679-8. Epub 2021 Feb 24. Oncogene. 2021. PMID: 33627786 Free PMC article.
We confirmed that USP13 expression was increased in cervical cancer cell lines, cytology samples from patients with cervical disease and in cervical cancer tissue. ...Together, our data demonstrates that USP13 is a potential oncogene in cervical can …
We confirmed that USP13 expression was increased in cervical cancer cell lines, cytology samples from patients with cervical d …
USP13 deubiquitinates and stabilizes cyclin D1 to promote gastric cancer cell cycle progression and cell proliferation.
Ma C, Wang D, Tian Z, Gao W, Zang Y, Qian L, Xu X, Jia J, Liu Z. Ma C, et al. Oncogene. 2023 Jul;42(29):2249-2262. doi: 10.1038/s41388-023-02739-x. Epub 2023 Jun 13. Oncogene. 2023. PMID: 37311811 Free PMC article.
The dysregulation of the DUBs may give rise to the occurrence and development of tumors. In this study, we investigated the gastric cancer (GC) data from the TCGA and GEO databases and found that ubiquitin-specific protease USP13 was significantly up-regulated in GC …
The dysregulation of the DUBs may give rise to the occurrence and development of tumors. In this study, we investigated the gastric cance …
USP13 genetics and expression in a family with thyroid cancer.
Maria AG, Azevedo B, Settas N, Hannah-Shmouni F, Stratakis CA, Faucz FR. Maria AG, et al. Endocrine. 2022 Aug;77(2):281-290. doi: 10.1007/s12020-022-03068-x. Epub 2022 May 18. Endocrine. 2022. PMID: 35583846 Free PMC article.
Studies regarding the role of USP13 in cancer development and progression are divergent and there are no previous data regarding the role of USP13 gene in PTCs. ...The USP13 c.1483G > A variant enhanced the effects seen in USP13 overexpressio …
Studies regarding the role of USP13 in cancer development and progression are divergent and there are no previous data regardi …
The Deubiquitinase USP13 Maintains Cancer Cell Stemness by Promoting FASN Stability in Small Cell Lung Cancer.
Wang J, Lin W, Li R, Cheng H, Sun S, Shao F, Yang Y, Zhang L, Feng X, Gao S, Gao Y, He J. Wang J, et al. Front Oncol. 2022 Jul 11;12:899987. doi: 10.3389/fonc.2022.899987. eCollection 2022. Front Oncol. 2022. PMID: 35898882 Free PMC article.
USP13 is significantly amplified in over 20% of lung cancer patients and critical for tumor progression. ...In vitro and in vivo depletion of USP13 inhibited SCLC cancer stem cells (CSCs) properties and tumorigenesis, and this inhibitory effect was res …
USP13 is significantly amplified in over 20% of lung cancer patients and critical for tumor progression. ...In vitro and in vi …
Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating beta-catenin.
Guo Y, Tian J, Guo Y, Wang C, Chen C, Cai S, Yu W, Sun B, Yan J, Li Z, Fan J, Qi Q, Zhang D, Jin W, Hua Z, Chen G. Guo Y, et al. Cell Rep. 2023 Dec 26;42(12):113511. doi: 10.1016/j.celrep.2023.113511. Epub 2023 Dec 2. Cell Rep. 2023. PMID: 38043062 Free article.
KRAS mutations are frequently detected in non-small cell lung cancers (NSCLCs). Although covalent KRAS(G12C) inhibitors have been developed to treat KRAS(G12C)-mutant cancers, effective treatments are still lacking for other KRAS-mutant NSCLCs. Thus, identifying a K …
KRAS mutations are frequently detected in non-small cell lung cancers (NSCLCs). Although covalent KRAS(G12C) inhibitors have been dev …
Deubiquitinase USP13 promotes the epithelial-mesenchymal transition and metastasis in gastric cancer by maintaining Snail protein.
Zhang T, Zheng J, Qiao L, Zhao W. Zhang T, et al. Pathol Res Pract. 2022 Jan;229:153705. doi: 10.1016/j.prp.2021.153705. Epub 2021 Nov 24. Pathol Res Pract. 2022. PMID: 34872023
A previous study reported that high USP13 mRNA expression confers poor prognosis in gastric cancer (GC). ...We also confirmed increased USP13 expression in GC cell lines. USP13 knockdown prominently suppressed MGC-803 cell migration and invasion. ...
A previous study reported that high USP13 mRNA expression confers poor prognosis in gastric cancer (GC). ...We also confirmed …
CK2-Mediated Phosphorylation Upregulates the Stability of USP13 and Promotes Ovarian Cancer Cell Proliferation.
Kwon J, Zhang J, Mok B, Han C. Kwon J, et al. Cancers (Basel). 2022 Dec 29;15(1):200. doi: 10.3390/cancers15010200. Cancers (Basel). 2022. PMID: 36612196 Free PMC article.
USP13 is highly amplified in human ovarian cancer, and elevated expression of USP13 promotes tumorigenesis and metastasis of ovarian cancer. ...Here, we found that USP13 is phosphorylated at Thr122 in ovarian cancer cells. Phosphorylated …
USP13 is highly amplified in human ovarian cancer, and elevated expression of USP13 promotes tumorigenesis and metastas …
USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity.
Kwon J, Zhang J, Mok B, Allsup S, Kim C, Toretsky J, Han C. Kwon J, et al. Mol Cancer. 2023 Dec 13;22(1):204. doi: 10.1186/s12943-023-01892-x. Mol Cancer. 2023. PMID: 38093367 Free PMC article.
Lung squamous cell carcinoma (LUSC) is associated with high mortality and limited targeted therapies. USP13 is one of the most amplified genes in LUSC, yet its role in lung cancer is largely unknown. ...We showed a strong molecular association between USP13 a …
Lung squamous cell carcinoma (LUSC) is associated with high mortality and limited targeted therapies. USP13 is one of the most amplif …
67 results