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Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial.
Lorentz CU, Verbout NG, Wallisch M, Hagen MW, Shatzel JJ, Olson SR, Puy C, Hinds MT, McCarty OJT, Gailani D, Gruber A, Tucker EI. Lorentz CU, et al. Among authors: wallisch m. Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):799-809. doi: 10.1161/ATVBAHA.118.312328. Arterioscler Thromb Vasc Biol. 2019. PMID: 30700130 Free PMC article. Clinical Trial.
The protein C activator AB002 rapidly interrupts thrombus development in baboons.
Tucker EI, Verbout NG, Markway BD, Wallisch M, Lorentz CU, Hinds MT, Shatzel JJ, Pelc LA, Wood DC, McCarty OJT, Di Cera E, Gruber A. Tucker EI, et al. Among authors: wallisch m. Blood. 2020 Feb 27;135(9):689-699. doi: 10.1182/blood.2019002771. Blood. 2020. PMID: 31977000 Free PMC article. Clinical Trial.
Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates.
Wallisch M, Lorentz CU, Lakshmanan HHS, Johnson J, Carris MR, Puy C, Gailani D, Hinds MT, McCarty OJT, Gruber A, Tucker EI. Wallisch M, et al. Res Pract Thromb Haemost. 2020 Feb 11;4(2):205-216. doi: 10.1002/rth2.12309. eCollection 2020 Feb. Res Pract Thromb Haemost. 2020. PMID: 32110750 Free PMC article.
Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus.
Silasi R, Keshari RS, Regmi G, Lupu C, Georgescu C, Simmons JH, Wallisch M, Kohs TCL, Shatzel JJ, Olson SR, Lorentz CU, Puy C, Tucker EI, Gailani D, Strickland S, Gruber A, McCarty OJT, Lupu F. Silasi R, et al. Among authors: wallisch m. Blood. 2021 Jul 15;138(2):178-189. doi: 10.1182/blood.2020009345. Blood. 2021. PMID: 33598692 Free PMC article.
Ibrutinib Inhibits BMX-Dependent Endothelial VCAM-1 Expression In Vitro and Pro-Atherosclerotic Endothelial Activation and Platelet Adhesion In Vivo.
Kohs TCL, Olson SR, Pang J, Jordan KR, Zheng TJ, Xie A, Hodovan J, Muller M, McArthur C, Johnson J, Sousa BB, Wallisch M, Kievit P, Aslan JE, Seixas JD, Bernardes GJL, Hinds MT, Lindner JR, McCarty OJT, Puy C, Shatzel JJ. Kohs TCL, et al. Among authors: wallisch m. Cell Mol Bioeng. 2022 Apr 18;15(3):231-243. doi: 10.1007/s12195-022-00723-1. eCollection 2022 Jun. Cell Mol Bioeng. 2022. PMID: 35611166 Free PMC article.
Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease.
Sparkenbaugh EM, Henderson MW, Miller-Awe M, Abrams C, Ilich A, Trebak F, Ramadas N, Vital S, Bohinc D, Bane KL, Chen C, Patel M, Wallisch M, Renné T, Gruber A, Cooley B, Gailani D, Kasztan M, Vercellotti GM, Belcher JD, Gavins FE, Stavrou EX, Key NS, Pawlinski R. Sparkenbaugh EM, et al. Among authors: wallisch m. Blood. 2023 Apr 13;141(15):1871-1883. doi: 10.1182/blood.2022017074. Blood. 2023. PMID: 36706361 Free PMC article.
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