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Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative.
Hotez PJ, Zhan B, Bethony JM, Loukas A, Williamson A, Goud GN, Hawdon JM, Dobardzic A, Dobardzic R, Ghosh K, Bottazzi ME, Mendez S, Zook B, Wang Y, Liu S, Essiet-Gibson I, Chung-Debose S, Xiao S, Knox D, Meagher M, Inan M, Correa-Oliveira R, Vilk P, Shepherd HR, Brandt W, Russell PK. Hotez PJ, et al. Among authors: wang y. Int J Parasitol. 2003 Sep 30;33(11):1245-58. doi: 10.1016/s0020-7519(03)00158-9. Int J Parasitol. 2003. PMID: 13678639 Review.
Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals.
Bethony J, Loukas A, Smout M, Brooker S, Mendez S, Plieskatt J, Goud G, Bottazzi ME, Zhan B, Wang Y, Williamson A, Lustigman S, Correa-Oliveira R, Xiao S, Hotez PJ. Bethony J, et al. Among authors: wang y. FASEB J. 2005 Oct;19(12):1743-5. doi: 10.1096/fj.05-3936fje. Epub 2005 Jul 21. FASEB J. 2005. PMID: 16037096
Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials.
Goud GN, Bottazzi ME, Zhan B, Mendez S, Deumic V, Plieskatt J, Liu S, Wang Y, Bueno L, Fujiwara R, Samuel A, Ahn SY, Solanki M, Asojo OA, Wang J, Bethony JM, Loukas A, Roy M, Hotez PJ. Goud GN, et al. Among authors: wang j, wang y. Vaccine. 2005 Sep 15;23(39):4754-64. doi: 10.1016/j.vaccine.2005.04.040. Vaccine. 2005. PMID: 16054275
Biochemical characterization and vaccine potential of a heme-binding glutathione transferase from the adult hookworm Ancylostoma caninum.
Zhan B, Liu S, Perally S, Xue J, Fujiwara R, Brophy P, Xiao S, Liu Y, Feng J, Williamson A, Wang Y, Bueno LL, Mendez S, Goud G, Bethony JM, Hawdon JM, Loukas A, Jones K, Hotez PJ. Zhan B, et al. Among authors: wang y. Infect Immun. 2005 Oct;73(10):6903-11. doi: 10.1128/IAI.73.10.6903-6911.2005. Infect Immun. 2005. PMID: 16177370 Free PMC article.
Reduction of worm fecundity and canine host blood loss mediates protection against hookworm infection elicited by vaccination with recombinant Ac-16.
Fujiwara RT, Zhan B, Mendez S, Loukas A, Bueno LL, Wang Y, Plieskatt J, Oksov Y, Lustigman S, Bottazzi ME, Hotez P, Bethony JM. Fujiwara RT, et al. Among authors: wang y. Clin Vaccine Immunol. 2007 Mar;14(3):281-7. doi: 10.1128/CVI.00404-06. Epub 2007 Jan 31. Clin Vaccine Immunol. 2007. PMID: 17267592 Free PMC article.
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