Wetzel JM - Search Results

1

Design and synthesis of novel alpha1a adrenoceptor-selective dihydropyridine antagonists for the treatment of benign prostatic hyperplasia.

Nagarathnam D, Wetzel JM, Miao SW, Marzabadi MR, Chiu G, Wong WC, Hong X, Fang J, Forray C, Branchek TA, Heydorn WE, Chang RS, Broten T, Schorn TW, Gluchowski C. Nagarathnam D, et al. Among authors: wetzel jm. J Med Chem. 1998 Dec 17;41(26):5320-33. doi: 10.1021/jm980506g. J Med Chem. 1998. PMID: 9857099

2

Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as selective alpha(1d)-adrenergic receptor antagonists.

Konkel MJ, Wetzel JM, Cahir M, Craig DA, Noble SA, Gluchowski C. Konkel MJ, et al. Among authors: wetzel jm. J Med Chem. 2005 Apr 21;48(8):3076-9. doi: 10.1021/jm0491391. J Med Chem. 2005. PMID: 15828846

3

Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits.

Chen CA, Jiang Y, Lu K, Daniewska I, Mazza CG, Negron L, Forray C, Parola T, Li B, Hegde LG, Wolinsky TD, Craig DA, Kong R, Wetzel JM, Andersen K, Marzabadi MR. Chen CA, et al. Among authors: wetzel jm. J Med Chem. 2007 Aug 9;50(16):3883-90. doi: 10.1021/jm060383x. J Med Chem. 2007. PMID: 17668922

4

Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine.

Wetzel JM, Miao SW, Forray C, Borden LA, Branchek TA, Gluchowski C. Wetzel JM, et al. J Med Chem. 1995 May 12;38(10):1579-81. doi: 10.1021/jm00010a001. J Med Chem. 1995. PMID: 7752182 No abstract available.

5

Identification of a dihydropyridine as a potent alpha1a adrenoceptor-selective antagonist that inhibits phenylephrine-induced contraction of the human prostate.

Wong WC, Chiu G, Wetzel JM, Marzabadi MR, Nagarathnam D, Wang D, Fang J, Miao SW, Hong X, Forray C, Vaysse PJ, Branchek TA, Gluchowski C, Tang R, Lepor H. Wong WC, et al. Among authors: wetzel jm. J Med Chem. 1998 Jul 2;41(14):2643-50. doi: 10.1021/jm980077m. J Med Chem. 1998. PMID: 9651170

6

Characterization of specific binding of [125I]L-762,459, a selective alpha1A-adrenoceptor radioligand to rat and human tissues.

O'Malley SS, Chen TB, Francis BE, Gibson RE, Burns HD, DiSalvo J, Bayne ML, Wetzel JM, Nagarathnam D, Marzabadi M, Gluchowski C, Chang RS. O'Malley SS, et al. Among authors: wetzel jm. Eur J Pharmacol. 1998 May 8;348(2-3):287-95. doi: 10.1016/s0014-2999(98)00149-6. Eur J Pharmacol. 1998. PMID: 9652345

7

Design and synthesis of novel dihydropyridine alpha-1a antagonists.

Marzabadi MR, Hong X, Nagarathnam D, Miao SW, Chiu G, Wong WC, Wetzel JM, Fang J, Forray C, Chen TB, O'Malley SS, Chang RS, Gluchowski C. Marzabadi MR, et al. Among authors: wetzel jm. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2843-8. doi: 10.1016/s0960-894x(99)00484-9. Bioorg Med Chem Lett. 1999. PMID: 10522703

8

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones.

Nagarathnam D, Miao SW, Lagu B, Chiu G, Fang J, Murali Dhar TG, Zhang J, Tyagarajan S, Marzabadi MR, Zhang F, Wong WC, Sun W, Tian D, Wetzel JM, Forray C, Chang RS, Broten TP, Ransom RW, Schorn TW, Chen TB, O'Malley S, Kling P, Schneck K, Bendesky R, Harrell CM, et al. Nagarathnam D, et al. Among authors: wetzel jm. J Med Chem. 1999 Nov 18;42(23):4764-77. doi: 10.1021/jm990200p. J Med Chem. 1999. PMID: 10579840

9

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety.

Murali Dhar TG, Nagarathnam D, Marzabadi MR, Lagu B, Wong WC, Chiu G, Tyagarajan S, Miao SW, Zhang F, Sun W, Tian D, Shen Q, Zhang J, Wetzel JM, Forray C, Chang RS, Broten TP, Schorn TW, Chen TB, O'Malley S, Ransom R, Schneck K, Bendesky R, Harrell CM, Vyas KP, et al. Murali Dhar TG, et al. Among authors: wetzel jm. J Med Chem. 1999 Nov 18;42(23):4778-93. doi: 10.1021/jm990201h. J Med Chem. 1999. PMID: 10579841

10

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series.

Wong WC, Sun W, Lagu B, Tian D, Marzabadi MR, Zhang F, Nagarathnam D, Miao SW, Wetzel JM, Peng J, Forray C, Chang RS, Chen TB, Ransom R, O'Malley S, Broten TP, Kling P, Vyas KP, Zhang K, Gluchowski C. Wong WC, et al. Among authors: wetzel jm. J Med Chem. 1999 Nov 18;42(23):4804-13. doi: 10.1021/jm9902032. J Med Chem. 1999. PMID: 10579843

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