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Global proteomics of Ubqln2-based murine models of ALS.
Whiteley AM, Prado MA, de Poot SAH, Paulo JA, Ashton M, Dominguez S, Weber M, Ngu H, Szpyt J, Jedrychowski MP, Easton A, Gygi SP, Kurz T, Monteiro MJ, Brown EJ, Finley D. Whiteley AM, et al. J Biol Chem. 2021 Jan-Jun;296:100153. doi: 10.1074/jbc.RA120.015960. Epub 2020 Dec 10. J Biol Chem. 2021. PMID: 33277362 Free PMC article.
ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function.
Wu JJ, Cai A, Greenslade JE, Higgins NR, Fan C, Le NTT, Tatman M, Whiteley AM, Prado MA, Dieriks BV, Curtis MA, Shaw CE, Siddique T, Faull RLM, Scotter EL, Finley D, Monteiro MJ. Wu JJ, et al. Among authors: whiteley am. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15230-15241. doi: 10.1073/pnas.1917371117. Epub 2020 Jun 8. Proc Natl Acad Sci U S A. 2020. PMID: 32513711 Free PMC article.
21 results