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Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction.
von Stockum S, Sanchez-Martinez A, Corrà S, Chakraborty J, Marchesan E, Locatello L, Da Rè C, Cusumano P, Caicci F, Ferrari V, Costa R, Bubacco L, Rasotto MB, Szabo I, Whitworth AJ, Scorrano L, Ziviani E. von Stockum S, et al. Among authors: whitworth aj. Life Sci Alliance. 2019 Apr 15;2(2):e201900392. doi: 10.26508/lsa.201900392. Print 2019 Apr. Life Sci Alliance. 2019. PMID: 30988163 Free PMC article.
Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration.
Loreto A, Hill CS, Hewitt VL, Orsomando G, Angeletti C, Gilley J, Lucci C, Sanchez-Martinez A, Whitworth AJ, Conforti L, Dajas-Bailador F, Coleman MP. Loreto A, et al. Among authors: whitworth aj. Neurobiol Dis. 2020 Feb;134:104678. doi: 10.1016/j.nbd.2019.104678. Epub 2019 Nov 15. Neurobiol Dis. 2020. PMID: 31740269 Free PMC article.
DJ-1: A promising therapeutic candidate for ischemia-reperfusion injury.
De Lazzari F, Prag HA, Gruszczyk AV, Whitworth AJ, Bisaglia M. De Lazzari F, et al. Among authors: whitworth aj. Redox Biol. 2021 May;41:101884. doi: 10.1016/j.redox.2021.101884. Epub 2021 Jan 30. Redox Biol. 2021. PMID: 33561740 Free PMC article. Review.
77 results