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Page 1
Medulloblastoma comprises four distinct molecular variants.
Northcott PA, Korshunov A, Witt H, Hielscher T, Eberhart CG, Mack S, Bouffet E, Clifford SC, Hawkins CE, French P, Rutka JT, Pfister S, Taylor MD. Northcott PA, et al. Among authors: witt h. J Clin Oncol. 2011 Apr 10;29(11):1408-14. doi: 10.1200/JCO.2009.27.4324. Epub 2010 Sep 7. J Clin Oncol. 2011. PMID: 20823417 Free PMC article.
Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes.
Korshunov A, Remke M, Gessi M, Ryzhova M, Hielscher T, Witt H, Tobias V, Buccoliero AM, Sardi I, Gardiman MP, Bonnin J, Scheithauer B, Kulozik AE, Witt O, Mork S, von Deimling A, Wiestler OD, Giangaspero F, Rosenblum M, Pietsch T, Lichter P, Pfister SM. Korshunov A, et al. Among authors: witt h, witt o. Acta Neuropathol. 2010 Aug;120(2):253-60. doi: 10.1007/s00401-010-0688-8. Epub 2010 Apr 21. Acta Neuropathol. 2010. PMID: 20407781
The genetics of pediatric brain tumors.
Dubuc AM, Northcott PA, Mack S, Witt H, Pfister S, Taylor MD. Dubuc AM, et al. Among authors: witt h. Curr Neurol Neurosci Rep. 2010 May;10(3):215-23. doi: 10.1007/s11910-010-0103-9. Curr Neurol Neurosci Rep. 2010. PMID: 20425037 Review.
Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification.
Korshunov A, Remke M, Werft W, Benner A, Ryzhova M, Witt H, Sturm D, Wittmann A, Schöttler A, Felsberg J, Reifenberger G, Rutkowski S, Scheurlen W, Kulozik AE, von Deimling A, Lichter P, Pfister SM. Korshunov A, et al. Among authors: witt h. J Clin Oncol. 2010 Jun 20;28(18):3054-60. doi: 10.1200/JCO.2009.25.7121. Epub 2010 May 17. J Clin Oncol. 2010. PMID: 20479417
Molecular staging of intracranial ependymoma in children and adults.
Korshunov A, Witt H, Hielscher T, Benner A, Remke M, Ryzhova M, Milde T, Bender S, Wittmann A, Schöttler A, Kulozik AE, Witt O, von Deimling A, Lichter P, Pfister S. Korshunov A, et al. Among authors: witt h, witt o. J Clin Oncol. 2010 Jul 1;28(19):3182-90. doi: 10.1200/JCO.2009.27.3359. Epub 2010 Jun 1. J Clin Oncol. 2010. PMID: 20516456
Role of LIM and SH3 protein 1 (LASP1) in the metastatic dissemination of medulloblastoma.
Traenka C, Remke M, Korshunov A, Bender S, Hielscher T, Northcott PA, Witt H, Ryzhova M, Felsberg J, Benner A, Riester S, Scheurlen W, Grunewald TG, von Deimling A, Kulozik AE, Reifenberger G, Taylor MD, Lichter P, Butt E, Pfister SM. Traenka C, et al. Among authors: witt h. Cancer Res. 2010 Oct 15;70(20):8003-14. doi: 10.1158/0008-5472.CAN-10-0592. Epub 2010 Oct 5. Cancer Res. 2010. PMID: 20924110
TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma.
Pfaff E, Remke M, Sturm D, Benner A, Witt H, Milde T, von Bueren AO, Wittmann A, Schöttler A, Jorch N, Graf N, Kulozik AE, Witt O, Scheurlen W, von Deimling A, Rutkowski S, Taylor MD, Tabori U, Lichter P, Korshunov A, Pfister SM. Pfaff E, et al. Among authors: witt h, witt o. J Clin Oncol. 2010 Dec 10;28(35):5188-96. doi: 10.1200/JCO.2010.31.1670. Epub 2010 Nov 8. J Clin Oncol. 2010. PMID: 21060032
An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice.
Gronych J, Korshunov A, Bageritz J, Milde T, Jugold M, Hambardzumyan D, Remke M, Hartmann C, Witt H, Jones DT, Witt O, Heiland S, Bendszus M, Holland EC, Pfister S, Lichter P. Gronych J, et al. Among authors: witt h, witt o. J Clin Invest. 2011 Apr;121(4):1344-8. doi: 10.1172/JCI44656. Epub 2011 Mar 14. J Clin Invest. 2011. PMID: 21403401 Free PMC article.
Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma.
Cin H, Meyer C, Herr R, Janzarik WG, Lambert S, Jones DT, Jacob K, Benner A, Witt H, Remke M, Bender S, Falkenstein F, Van Anh TN, Olbrich H, von Deimling A, Pekrun A, Kulozik AE, Gnekow A, Scheurlen W, Witt O, Omran H, Jabado N, Collins VP, Brummer T, Marschalek R, Lichter P, Korshunov A, Pfister SM. Cin H, et al. Among authors: witt h, witt o. Acta Neuropathol. 2011 Jun;121(6):763-74. doi: 10.1007/s00401-011-0817-z. Epub 2011 Mar 20. Acta Neuropathol. 2011. PMID: 21424530
471 results