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Structural basis for activation of DNMT1.
Kikuchi A, Onoda H, Yamaguchi K, Kori S, Matsuzawa S, Chiba Y, Tanimoto S, Yoshimi S, Sato H, Yamagata A, Shirouzu M, Adachi N, Sharif J, Koseki H, Nishiyama A, Nakanishi M, Defossez PA, Arita K. Kikuchi A, et al. Among authors: yamaguchi k. Nat Commun. 2022 Nov 21;13(1):7130. doi: 10.1038/s41467-022-34779-4. Nat Commun. 2022. PMID: 36414620 Free PMC article.
Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1.
Kori S, Shibahashi Y, Ekimoto T, Nishiyama A, Yoshimi S, Yamaguchi K, Nagatoishi S, Ohta M, Tsumoto K, Nakanishi M, Defossez PA, Ikeguchi M, Arita K. Kori S, et al. Among authors: yamaguchi k. Bioorg Med Chem. 2021 Dec 15;52:116500. doi: 10.1016/j.bmc.2021.116500. Epub 2021 Nov 10. Bioorg Med Chem. 2021. PMID: 34801826
Large-Scale Chromatin Rearrangements in Cancer.
Yamaguchi K, Chen X, Oji A, Hiratani I, Defossez PA. Yamaguchi K, et al. Cancers (Basel). 2022 May 12;14(10):2384. doi: 10.3390/cancers14102384. Cancers (Basel). 2022. PMID: 35625988 Free PMC article. Review.
A genome-wide screen reveals new regulators of the 2-cell-like cell state.
Gupta N, Yakhou L, Albert JR, Azogui A, Ferry L, Kirsh O, Miura F, Battault S, Yamaguchi K, Laisné M, Domrane C, Bonhomme F, Sarkar A, Delagrange M, Ducos B, Cristofari G, Ito T, Greenberg MVC, Defossez PA. Gupta N, et al. Among authors: yamaguchi k. Nat Struct Mol Biol. 2023 Aug;30(8):1105-1118. doi: 10.1038/s41594-023-01038-z. Epub 2023 Jul 24. Nat Struct Mol Biol. 2023. PMID: 37488355
A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation.
Yakhou L, Azogui A, Gupta N, Richard Albert J, Miura F, Ferry L, Yamaguchi K, Battault S, Therizols P, Bonhomme F, Bethuel E, Sarkar A, Greenberg MVC, Arimondo PB, Cristofari G, Kirsh O, Ito T, Defossez PA. Yakhou L, et al. Among authors: yamaguchi k. Nucleic Acids Res. 2023 Oct 27;51(19):10292-10308. doi: 10.1093/nar/gkad719. Nucleic Acids Res. 2023. PMID: 37650637 Free PMC article.
Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells.
Yamaguchi K, Chen X, Rodgers B, Miura F, Bashtrykov P, Bonhomme F, Salinas-Luypaert C, Haxholli D, Gutekunst N, Aygenli BÖ, Ferry L, Kirsh O, Laisné M, Scelfo A, Ugur E, Arimondo PB, Leonhardt H, Kanemaki MT, Bartke T, Fachinetti D, Jeltsch A, Ito T, Defossez PA. Yamaguchi K, et al. Nat Commun. 2024 Apr 5;15(1):2960. doi: 10.1038/s41467-024-47314-4. Nat Commun. 2024. PMID: 38580649 Free PMC article.
Genetic and Immunological Characterization of Brain Metastases from Solid Cancers.
Deguchi S, Akiyama Y, Mitsuya K, Ikeya T, Hozumi C, Iizuka A, Miyata H, Maeda C, Ashizawa T, Nagashima T, Urakami K, Ohshima K, Muramatsu K, Sugino T, Ohde Y, Tsubosa Y, Nishimura S, Yamaguchi K. Deguchi S, et al. Among authors: yamaguchi k. Anticancer Res. 2024 May;44(5):1983-1994. doi: 10.21873/anticanres.17001. Anticancer Res. 2024. PMID: 38677762
7,499 results