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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 2
1980 2
1981 4
1983 3
1984 6
1985 4
1986 10
1987 5
1988 8
1989 6
1990 4
1991 8
1992 1
1993 3
1994 7
1995 6
1996 4
1997 5
1998 5
1999 3
2000 1
2001 1
2002 4
2003 1
2004 4
2005 4
2006 3
2007 10
2008 8
2009 3
2010 2
2011 6
2012 4
2013 6
2014 8
2015 8
2016 8
2017 11
2018 15
2019 10
2020 5
2021 1
2022 5
2023 15
2024 4

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218 results

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Page 1
Neurophysiological symptoms and aspartame: What is the connection?
Choudhary AK, Lee YY. Choudhary AK, et al. Nutr Neurosci. 2018 Jun;21(5):306-316. doi: 10.1080/1028415X.2017.1288340. Epub 2017 Feb 15. Nutr Neurosci. 2018. PMID: 28198207 Review.
Possible neurophysiological symptoms include learning problems, headache, seizure, migraines, irritable moods, anxiety, depression, and insomnia. The consumption of aspartame, unlike dietary protein, can elevate the levels of phenylalanine and aspartic acid in the brain …
Possible neurophysiological symptoms include learning problems, headache, seizure, migraines, irritable moods, anxiety, depression, and inso …
Revisiting the safety of aspartame.
Choudhary AK, Pretorius E. Choudhary AK, et al. Nutr Rev. 2017 Sep 1;75(9):718-730. doi: 10.1093/nutrit/nux035. Nutr Rev. 2017. PMID: 28938797 Review.
Aspartame is a synthetic dipeptide artificial sweetener, frequently used in foods, medications, and beverages, notably carbonated and powdered soft drinks. ...Since aspartame consumption is on the rise, the safety of this sweetener should be revisited. ...
Aspartame is a synthetic dipeptide artificial sweetener, frequently used in foods, medications, and beverages, notably carbonated and …
Transgenerational transmission of aspartame-induced anxiety and changes in glutamate-GABA signaling and gene expression in the amygdala.
Jones SK, McCarthy DM, Vied C, Stanwood GD, Schatschneider C, Bhide PG. Jones SK, et al. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2213120119. doi: 10.1073/pnas.2213120119. Epub 2022 Dec 2. Proc Natl Acad Sci U S A. 2022. PMID: 36459641 Free PMC article.
We report the effects of aspartame on anxiety-like behavior, neurotransmitter signaling and gene expression in the amygdala, a brain region associated with the regulation of anxiety and fear responses. ...Thus, human population at risk of aspartame's p …
We report the effects of aspartame on anxiety-like behavior, neurotransmitter signaling and gene expression in the amygdala, a bra …
Artificial sweeteners induce glucose intolerance by altering the gut microbiota.
Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Maza O, Israeli D, Zmora N, Gilad S, Weinberger A, Kuperman Y, Harmelin A, Kolodkin-Gal I, Shapiro H, Halpern Z, Segal E, Elinav E. Suez J, et al. Nature. 2014 Oct 9;514(7521):181-6. doi: 10.1038/nature13793. Epub 2014 Sep 17. Nature. 2014. PMID: 25231862
Direct and indirect cellular effects of aspartame on the brain.
Humphries P, Pretorius E, Naudé H. Humphries P, et al. Eur J Clin Nutr. 2008 Apr;62(4):451-62. doi: 10.1038/sj.ejcn.1602866. Epub 2007 Aug 8. Eur J Clin Nutr. 2008. PMID: 17684524 Review.
Aspartame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%). ...The aim of this study was to discuss the direct and indirect cellular effects of aspartame on the brain, and we propose that excessive aspartame ingestion might be …
Aspartame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%). ...The aim of this study was to discuss the dir …
Aspartame and brain cancer.
Roberts HJ. Roberts HJ. Lancet. 1997 Feb 1;349(9048):362. doi: 10.1016/s0140-6736(05)62868-1. Lancet. 1997. PMID: 9024408 No abstract available.
Aspartame and Its Metabolites Cause Oxidative Stress and Mitochondrial and Lipid Alterations in SH-SY5Y Cells.
Griebsch LV, Theiss EL, Janitschke D, Erhardt VKJ, Erhardt T, Haas EC, Kuppler KN, Radermacher J, Walzer O, Lauer AA, Matschke V, Hartmann T, Grimm MOW, Grimm HS. Griebsch LV, et al. Nutrients. 2023 Mar 18;15(6):1467. doi: 10.3390/nu15061467. Nutrients. 2023. PMID: 36986196 Free PMC article.
Due to a worldwide increase in obesity and metabolic disorders such as type 2 diabetes, synthetic sweeteners such as aspartame are frequently used to substitute sugar in the diet. Possible uncertainties regarding aspartame's ability to induce oxidative stress …
Due to a worldwide increase in obesity and metabolic disorders such as type 2 diabetes, synthetic sweeteners such as aspartame are fr …
Sugar consumption, metabolic disease and obesity: The state of the controversy.
Stanhope KL. Stanhope KL. Crit Rev Clin Lab Sci. 2016;53(1):52-67. doi: 10.3109/10408363.2015.1084990. Epub 2015 Sep 17. Crit Rev Clin Lab Sci. 2016. PMID: 26376619 Free PMC article. Review.
Mechanistically, it is plausible that fructose consumption causes increased energy intake and reduced energy expenditure due to its failure to stimulate leptin production. Functional magnetic resonance imaging (fMRI) of the brain demonstrates that the brain responds …
Mechanistically, it is plausible that fructose consumption causes increased energy intake and reduced energy expenditure due to its failure …
Behavioral and electrophysiological brain effects of aspartame on well-nourished and malnourished rats.
Magalhães PCG, Abadie-Guedes R, da Costa Mendonça MAB, de Souza AD, Guedes RCA. Magalhães PCG, et al. Metab Brain Dis. 2019 Apr;34(2):651-658. doi: 10.1007/s11011-018-0361-9. Epub 2018 Dec 13. Metab Brain Dis. 2019. PMID: 30547285
The non-caloric sweetener aspartame can be potentially harmful to the developing brain, as some studies suggest an association between aspartame intake and adverse neural effects. ...The data suggest caution in aspartame consumption by lactating mother …
The non-caloric sweetener aspartame can be potentially harmful to the developing brain, as some studies suggest an association …
Maternal low-dose aspartame and stevia consumption with an obesogenic diet alters metabolism, gut microbiota and mesolimbic reward system in rat dams and their offspring.
Nettleton JE, Cho NA, Klancic T, Nicolucci AC, Shearer J, Borgland SL, Johnston LA, Ramay HR, Noye Tuplin E, Chleilat F, Thomson C, Mayengbam S, McCoy KD, Reimer RA. Nettleton JE, et al. Gut. 2020 Oct;69(10):1807-1817. doi: 10.1136/gutjnl-2018-317505. Epub 2020 Jan 29. Gut. 2020. PMID: 31996393 Free PMC article.
OBJECTIVE: We examined the impact of maternal low-dose aspartame and stevia consumption on adiposity, glucose tolerance, gut microbiota and mesolimbic pathway in obese dams and their offspring. DESIGN: Following obesity induction, female Sprague-Dawley rats were allocated …
OBJECTIVE: We examined the impact of maternal low-dose aspartame and stevia consumption on adiposity, glucose tolerance, gut microbio …
218 results