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ATRX, a guardian of chromatin.
Aguilera P, López-Contreras AJ. Aguilera P, et al. Trends Genet. 2023 Jun;39(6):505-519. doi: 10.1016/j.tig.2023.02.009. Epub 2023 Mar 7. Trends Genet. 2023. PMID: 36894374 Free article. Review.
ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated tumor suppressor genes in human cancers, especially in glioma, and recent findings indicate roles for ATRX in key molecular pathways, such as the regulation of chromatin state …
ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated tumor suppressor genes in human cancers, e …
ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma.
Han B, Meng X, Wu P, Li Z, Li S, Zhang Y, Zha C, Ye Q, Jiang C, Cai J, Jiang T. Han B, et al. Theranostics. 2020 Feb 10;10(7):3351-3365. doi: 10.7150/thno.41219. eCollection 2020. Theranostics. 2020. PMID: 32194873 Free PMC article.
CRISPR-Cas9 gene editing system was used to achieve the ATRX knockout in TMZ resistant cells. In vitro and in vivo experiments were carried out to investigate the role of ATRX contributing to TMZ resistance in glioma. ...ATRX elicited PARP1 stabilization by t …
CRISPR-Cas9 gene editing system was used to achieve the ATRX knockout in TMZ resistant cells. In vitro and in vivo experiments were c …
ATRX/DAXX: Guarding the Genome against the Hazards of ALT.
Clatterbuck Soper SF, Meltzer PS. Clatterbuck Soper SF, et al. Genes (Basel). 2023 Mar 24;14(4):790. doi: 10.3390/genes14040790. Genes (Basel). 2023. PMID: 37107548 Free PMC article. Review.
The ALT process is linked to mutations in the ATRX/DAXX/H3.3 histone chaperone complex. This complex is responsible for depositing non-replicative histone variant H3.3 at pericentric and telomeric heterochromatin but has also been found to have roles in ameliorating replic …
The ALT process is linked to mutations in the ATRX/DAXX/H3.3 histone chaperone complex. This complex is responsible for depositing no …
ATRX and DAXX: Mechanisms and Mutations.
Dyer MA, Qadeer ZA, Valle-Garcia D, Bernstein E. Dyer MA, et al. Cold Spring Harb Perspect Med. 2017 Mar 1;7(3):a026567. doi: 10.1101/cshperspect.a026567. Cold Spring Harb Perspect Med. 2017. PMID: 28062559 Free PMC article. Review.
These regions include retrotransposons, pericentric heterochromatin, and telomeres, the latter of which show deregulation in ATRX/DAXX-mutant tumors. Interestingly, ATRX and DAXX mutations are often found in pediatric tumors, suggesting a particular developmental co …
These regions include retrotransposons, pericentric heterochromatin, and telomeres, the latter of which show deregulation in ATRX/DAX …
The Multiple Facets of ATRX Protein.
Valenzuela M, Amato R, Sgura A, Antoccia A, Berardinelli F. Valenzuela M, et al. Cancers (Basel). 2021 May 5;13(9):2211. doi: 10.3390/cancers13092211. Cancers (Basel). 2021. PMID: 34062956 Free PMC article. Review.
ATRX gene codifies for a protein member of the SWI-SNF family and was cloned for the first time over 25 years ago as the gene responsible for a rare developmental disorder characterized by alpha-thalassemia and intellectual disability called Alpha Thalassemia/mental Retard …
ATRX gene codifies for a protein member of the SWI-SNF family and was cloned for the first time over 25 years ago as the gene respons …
Mutant ATRX: pathogenesis of ATRX syndrome and cancer.
Yuan K, Tang Y, Ding Z, Peng L, Zeng J, Wu H, Yi Q. Yuan K, et al. Front Mol Biosci. 2024 Oct 16;11:1434398. doi: 10.3389/fmolb.2024.1434398. eCollection 2024. Front Mol Biosci. 2024. PMID: 39479502 Free PMC article. Review.
ATRX mutations substantially contribute to the pathogenesis of ATRX syndrome and are frequently detected in gliomas and many other cancers. ...In conclusion, ATRX is a central protein whose abnormalities lead to multiple diseases....
ATRX mutations substantially contribute to the pathogenesis of ATRX syndrome and are frequently detected in gliomas and many o …
Loss of ATRX suppresses anti-tumor immunity.
Diaz AA. Diaz AA. Neuro Oncol. 2022 Jun 1;24(6):901-902. doi: 10.1093/neuonc/noac059. Neuro Oncol. 2022. PMID: 35235678 Free PMC article. No abstract available.
Mutant ATRX: uncovering a new therapeutic target for glioma.
Haase S, Garcia-Fabiani MB, Carney S, Altshuler D, Núñez FJ, Méndez FM, Núñez F, Lowenstein PR, Castro MG. Haase S, et al. Expert Opin Ther Targets. 2018 Jul;22(7):599-613. doi: 10.1080/14728222.2018.1487953. Epub 2018 Jun 20. Expert Opin Ther Targets. 2018. PMID: 29889582 Free PMC article. Review.
ATRX is a chromatin remodeling protein whose main function is the deposition of the histone variant H3.3. ...Areas covered: We discuss the main molecular characteristics of ATRX, from its various functions in normal development to the effects of its loss in ATRX …
ATRX is a chromatin remodeling protein whose main function is the deposition of the histone variant H3.3. ...Areas covered: We discus …
ATRX loss promotes immunosuppressive mechanisms in IDH1 mutant glioma.
Hu C, Wang K, Damon C, Fu Y, Ma T, Kratz L, Lal B, Ying M, Xia S, Cahill DP, Jackson CM, Lim M, Laterra J, Li Y. Hu C, et al. Neuro Oncol. 2022 Jun 1;24(6):888-900. doi: 10.1093/neuonc/noab292. Neuro Oncol. 2022. PMID: 34951647 Free PMC article.
BACKGROUND: ATRX inactivation occurs with IDH1R132H and p53 mutations in over 80% of Grades II/III astrocytomas. ...This paper examines how ATRX loss contributes to the malignant and immunosuppressive phenotypes of IDH1R132H/p53mut glioma cells and xenografts. ...
BACKGROUND: ATRX inactivation occurs with IDH1R132H and p53 mutations in over 80% of Grades II/III astrocytomas. ...This paper examin …
The Chromatin Remodeler ATRX: Role and Mechanism in Biology and Cancer.
Pang Y, Chen X, Ji T, Cheng M, Wang R, Zhang C, Liu M, Zhang J, Zhong C. Pang Y, et al. Cancers (Basel). 2023 Apr 10;15(8):2228. doi: 10.3390/cancers15082228. Cancers (Basel). 2023. PMID: 37190157 Free PMC article. Review.
ATRX mutations not only cause ATRX syndrome but also influence development and promote cancer. ...As mechanistic and molecular investigations on ATRX disclose its essential functions in cancer, customized therapies targeting ATRX will become accessible …
ATRX mutations not only cause ATRX syndrome but also influence development and promote cancer. ...As mechanistic and molecular …
1,913 results

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