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Year Number of Results
1986 1
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1998 6
1999 10
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1,704 results

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ATRX, a guardian of chromatin.
Aguilera P, López-Contreras AJ. Aguilera P, et al. Trends Genet. 2023 Jun;39(6):505-519. doi: 10.1016/j.tig.2023.02.009. Epub 2023 Mar 7. Trends Genet. 2023. PMID: 36894374 Free article. Review.
ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated tumor suppressor genes in human cancers, especially in glioma, and recent findings indicate roles for ATRX in key molecular pathways, such as the regulation of chromatin state …
ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated tumor suppressor genes in human cancers, e …
DAXX-ATRX regulation of p53 chromatin binding and DNA damage response.
Gulve N, Su C, Deng Z, Soldan SS, Vladimirova O, Wickramasinghe J, Zheng H, Kossenkov AV, Lieberman PM. Gulve N, et al. Nat Commun. 2022 Aug 26;13(1):5033. doi: 10.1038/s41467-022-32680-8. Nat Commun. 2022. PMID: 36028493 Free PMC article.
DAXX and ATRX are tumor suppressor proteins that form a histone H3.3 chaperone complex and are frequently mutated in cancers with the alternative lengthening of telomeres (ALT). Here, we show that DAXX and ATRX knock-out (KO) U87-T cells that have acquired ALT-like …
DAXX and ATRX are tumor suppressor proteins that form a histone H3.3 chaperone complex and are frequently mutated in cancers with the …
ATRX/DAXX: Guarding the Genome against the Hazards of ALT.
Clatterbuck Soper SF, Meltzer PS. Clatterbuck Soper SF, et al. Genes (Basel). 2023 Mar 24;14(4):790. doi: 10.3390/genes14040790. Genes (Basel). 2023. PMID: 37107548 Free PMC article. Review.
In a subset of tumors, telomeres are maintained not by telomerase, but through a homologous recombination-based mechanism termed Alternative Lengthening of Telomeres or ALT. The ALT process is linked to mutations in the ATRX/DAXX/H3.3 histone chaperone complex. This comple …
In a subset of tumors, telomeres are maintained not by telomerase, but through a homologous recombination-based mechanism termed Alternative …
ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma.
Han B, Meng X, Wu P, Li Z, Li S, Zhang Y, Zha C, Ye Q, Jiang C, Cai J, Jiang T. Han B, et al. Theranostics. 2020 Feb 10;10(7):3351-3365. doi: 10.7150/thno.41219. eCollection 2020. Theranostics. 2020. PMID: 32194873 Free PMC article.
Therefore, elucidation of the role of ATRX contributing to TMZ resistance in glioma is urgently needed. ...ATRX elicited PARP1 stabilization by the down-regulating of FADD expression via the H3K27me3 enrichment, which was dependent on ATRX/EZH2 complex in TMZ …
Therefore, elucidation of the role of ATRX contributing to TMZ resistance in glioma is urgently needed. ...ATRX elicited PARP1 …
ATRX and DAXX: Mechanisms and Mutations.
Dyer MA, Qadeer ZA, Valle-Garcia D, Bernstein E. Dyer MA, et al. Cold Spring Harb Perspect Med. 2017 Mar 1;7(3):a026567. doi: 10.1101/cshperspect.a026567. Cold Spring Harb Perspect Med. 2017. PMID: 28062559 Free PMC article. Review.
These regions include retrotransposons, pericentric heterochromatin, and telomeres, the latter of which show deregulation in ATRX/DAXX-mutant tumors. Interestingly, ATRX and DAXX mutations are often found in pediatric tumors, suggesting a particular developmental co …
These regions include retrotransposons, pericentric heterochromatin, and telomeres, the latter of which show deregulation in ATRX/DAX …
The Multiple Facets of ATRX Protein.
Valenzuela M, Amato R, Sgura A, Antoccia A, Berardinelli F. Valenzuela M, et al. Cancers (Basel). 2021 May 5;13(9):2211. doi: 10.3390/cancers13092211. Cancers (Basel). 2021. PMID: 34062956 Free PMC article. Review.
ATRX gene codifies for a protein member of the SWI-SNF family and was cloned for the first time over 25 years ago as the gene responsible for a rare developmental disorder characterized by alpha-thalassemia and intellectual disability called Alpha Thalassemia/mental Retard …
ATRX gene codifies for a protein member of the SWI-SNF family and was cloned for the first time over 25 years ago as the gene respons …
The Chromatin Remodeler ATRX: Role and Mechanism in Biology and Cancer.
Pang Y, Chen X, Ji T, Cheng M, Wang R, Zhang C, Liu M, Zhang J, Zhong C. Pang Y, et al. Cancers (Basel). 2023 Apr 10;15(8):2228. doi: 10.3390/cancers15082228. Cancers (Basel). 2023. PMID: 37190157 Free PMC article. Review.
ATRX mutations not only cause ATRX syndrome but also influence development and promote cancer. ...However, the nature of its involvement in the growth and development of cancer remains unknown. As mechanistic and molecular investigations on ATRX disclose its …
ATRX mutations not only cause ATRX syndrome but also influence development and promote cancer. ...However, the nature of its i …
Mutant ATRX: uncovering a new therapeutic target for glioma.
Haase S, Garcia-Fabiani MB, Carney S, Altshuler D, Núñez FJ, Méndez FM, Núñez F, Lowenstein PR, Castro MG. Haase S, et al. Expert Opin Ther Targets. 2018 Jul;22(7):599-613. doi: 10.1080/14728222.2018.1487953. Epub 2018 Jun 20. Expert Opin Ther Targets. 2018. PMID: 29889582 Free PMC article. Review.
ATRX is a chromatin remodeling protein whose main function is the deposition of the histone variant H3.3. ...Areas covered: We discuss the main molecular characteristics of ATRX, from its various functions in normal development to the effects of its loss in ATRX …
ATRX is a chromatin remodeling protein whose main function is the deposition of the histone variant H3.3. ...Areas covered: We discus …
Loss of ATRX suppresses anti-tumor immunity.
Diaz AA. Diaz AA. Neuro Oncol. 2022 Jun 1;24(6):901-902. doi: 10.1093/neuonc/noac059. Neuro Oncol. 2022. PMID: 35235678 Free PMC article. No abstract available.
The Role of ATRX in Glioma Biology.
Nandakumar P, Mansouri A, Das S. Nandakumar P, et al. Front Oncol. 2017 Sep 29;7:236. doi: 10.3389/fonc.2017.00236. eCollection 2017. Front Oncol. 2017. PMID: 29034211 Free PMC article. Review.
In this review, we will first provide an overview of the role of ATRX in regular cell biology. Furthermore, the role of ATRX in tumorigenesis, specifically gliomas, is comprehensively elucidated. The possible correlation of ATRX status with other genetic/epig …
In this review, we will first provide an overview of the role of ATRX in regular cell biology. Furthermore, the role of ATRX i …
1,704 results

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