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2,106 results

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Page 1
ATRX, a guardian of chromatin.
Aguilera P, López-Contreras AJ. Aguilera P, et al. Trends Genet. 2023 Jun;39(6):505-519. doi: 10.1016/j.tig.2023.02.009. Epub 2023 Mar 7. Trends Genet. 2023. PMID: 36894374 Free article. Review.
ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated tumor suppressor genes in human cancers, especially in glioma, and recent findings indicate roles for ATRX in key molecular pathways, such as the regulation of chromatin state …
ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated tumor suppressor genes in human cancers, e …
ATRX: From Chromatin Remodeling to Disease.
Magaña-Acosta M, Valadez-Graham V. Magaña-Acosta M, et al. Genesis. 2025 Dec;63(6):e70031. doi: 10.1002/dvg.70031. Genesis. 2025. PMID: 41222108 Free PMC article. Review.
We further discuss and integrate current findings on pathologies associated with ATRX dysfunction such as ATR-X syndrome, focusing on its etiology, clinical features, and potential diagnostic tools. Finally, we propose that ATRX may contribute t …
We further discuss and integrate current findings on pathologies associated with ATRX dysfunction such as ATR-X synd …
ATRX and DAXX: Mechanisms and Mutations.
Dyer MA, Qadeer ZA, Valle-Garcia D, Bernstein E. Dyer MA, et al. Cold Spring Harb Perspect Med. 2017 Mar 1;7(3):a026567. doi: 10.1101/cshperspect.a026567. Cold Spring Harb Perspect Med. 2017. PMID: 28062559 Free PMC article. Review.
These regions include retrotransposons, pericentric heterochromatin, and telomeres, the latter of which show deregulation in ATRX/DAXX-mutant tumors. Interestingly, ATRX and DAXX mutations are often found in pediatric tumors, suggesting a particular developmental co …
These regions include retrotransposons, pericentric heterochromatin, and telomeres, the latter of which show deregulation in ATRX/DAX …
ATRX and sex differentiation.
Tang P, Park DJ, Marshall Graves JA, Harley VR. Tang P, et al. Trends Endocrinol Metab. 2004 Sep;15(7):339-44. doi: 10.1016/j.tem.2004.07.006. Trends Endocrinol Metab. 2004. PMID: 15350606 Review.
Although the biochemical role of ATRX remains unknown, recent and emerging evidence implicates ATRX in chromatin remodeling. We review what is known about ATRX as a chromatin remodeling protein, and its role in mammalian sex differentiation....
Although the biochemical role of ATRX remains unknown, recent and emerging evidence implicates ATRX in chromatin remodeling. W …
Mutant ATRX: uncovering a new therapeutic target for glioma.
Haase S, Garcia-Fabiani MB, Carney S, Altshuler D, Núñez FJ, Méndez FM, Núñez F, Lowenstein PR, Castro MG. Haase S, et al. Expert Opin Ther Targets. 2018 Jul;22(7):599-613. doi: 10.1080/14728222.2018.1487953. Epub 2018 Jun 20. Expert Opin Ther Targets. 2018. PMID: 29889582 Free PMC article. Review.
ATRX is a chromatin remodeling protein whose main function is the deposition of the histone variant H3.3. ...Areas covered: We discuss the main molecular characteristics of ATRX, from its various functions in normal development to the effects of its loss in ATRX …
ATRX is a chromatin remodeling protein whose main function is the deposition of the histone variant H3.3. ...Areas covered: We discus …
Loss of ATRX suppresses anti-tumor immunity.
Diaz AA. Diaz AA. Neuro Oncol. 2022 Jun 1;24(6):901-902. doi: 10.1093/neuonc/noac059. Neuro Oncol. 2022. PMID: 35235678 Free PMC article. No abstract available.
ATRX cooperates with TOP2B for replication fork stability and DNA damage response through G-quadruplex regulation.
Pang Y, Cheng M, Wang J, Wang R, Chen X, Zhang C, Yang Y, Ji T, Liu M, Zhang J, Zhong C. Pang Y, et al. Nucleic Acids Res. 2025 Sep 23;53(18):gkaf939. doi: 10.1093/nar/gkaf939. Nucleic Acids Res. 2025. PMID: 40990248 Free PMC article.
Mechanistically, CX-5461 acts as a TOP2B poison that selectively impairs TOP2B binding at G4 sites, alters replication fork dynamics, and induces MRE11-dependent degradation of stalled forks. These effects are strongly enhanced in ATRX-deficient glioma cells, where TOP2B p …
Mechanistically, CX-5461 acts as a TOP2B poison that selectively impairs TOP2B binding at G4 sites, alters replication fork dynamics, and in …
Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas.
Hariharan S, Whitfield BT, Pirozzi CJ, Waitkus MS, Brown MC, Bowie ML, Irvin DM, Roso K, Fuller R, Hostettler J, Dharmaiah S, Gibson EA, Briley A, Mangoli A, Fraley C, Shobande M, Stevenson K, Zhang G, Malgulwar PB, Roberts H, Roskoski M, Spasojevic I, Keir ST, He Y, Castro MG, Huse JT, Ashley DM. Hariharan S, et al. Nat Commun. 2024 Jan 25;15(1):730. doi: 10.1038/s41467-024-44932-w. Nat Commun. 2024. PMID: 38272925 Free PMC article.
However, little is known about the interplay between ATRX loss and IDH mutation on innate immunity. To explore this, we generated ATRX-deficient glioma models in the presence and absence of the IDH1(R132H) mutation. ...IDH1(R132H) co-expression does not interfere wi …
However, little is known about the interplay between ATRX loss and IDH mutation on innate immunity. To explore this, we generated …
Phase separated condensates of ATRX regulate neural progenitor identity.
Tomooka R, Sanosaka T, Miyagi T, Andoh-Noda T, Banno S, Mizota N, Kanekura K, Okano H, Kohyama J. Tomooka R, et al. Nat Commun. 2025 Jul 14;16(1):6489. doi: 10.1038/s41467-025-61881-0. Nat Commun. 2025. PMID: 40659667 Free PMC article.
Mutations in the ATRX genes cause alpha-thalassemia X-linked intellectual disability (ATR-X) syndrome. ...This study opens avenues for further investigation into how dysregulation of ATRX and its phase-separation ability may contribute to the pa …
Mutations in the ATRX genes cause alpha-thalassemia X-linked intellectual disability (ATR-X) syndrome. ...This s …
Correlation between IDH, ATRX, and TERT promoter mutations in glioma.
Ohba S, Kuwahara K, Yamada S, Abe M, Hirose Y. Ohba S, et al. Brain Tumor Pathol. 2020 Apr;37(2):33-40. doi: 10.1007/s10014-020-00360-4. Epub 2020 Mar 29. Brain Tumor Pathol. 2020. PMID: 32227259 Review.
This study analyzed IDH, ATRX, and TERT promoter mutations, and the correlation between them. Immortalized cells overcome the telomere-related crisis by activating telomerase or ALT. In glioma, telomerase is mainly activated by TERT promoter mutation, while ALT is usually …
This study analyzed IDH, ATRX, and TERT promoter mutations, and the correlation between them. Immortalized cells overcome the telomer …
2,106 results