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Year Number of Results
1946 4
1947 3
1948 3
1949 7
1950 2
1951 5
1952 5
1953 3
1954 5
1955 6
1956 2
1957 8
1958 7
1959 11
1960 16
1961 16
1962 35
1963 33
1964 42
1965 33
1966 31
1967 76
1968 94
1969 112
1970 113
1971 142
1972 151
1973 287
1974 373
1975 559
1976 693
1977 660
1978 776
1979 904
1980 1190
1981 1209
1982 1461
1983 1704
1984 1996
1985 2622
1986 3243
1987 4031
1988 5520
1989 6924
1990 7974
1991 8697
1992 9657
1993 10902
1994 11412
1995 12318
1996 13559
1997 14590
1998 15378
1999 16075
2000 17345
2001 18351
2002 19495
2003 21122
2004 23058
2005 26658
2006 27811
2007 30344
2008 32825
2009 35480
2010 39929
2011 44493
2012 49779
2013 53338
2014 56179
2015 60968
2016 63743
2017 67372
2018 69693
2019 74566
2020 81114
2021 84430
2022 75437
2023 68216
2024 27463

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C-Reactive Protein Velocity (CRPv) as a New Biomarker for the Early Detection of Acute Infection/Inflammation.
Levinson T, Wasserman A. Levinson T, et al. Int J Mol Sci. 2022 Jul 22;23(15):8100. doi: 10.3390/ijms23158100. Int J Mol Sci. 2022. PMID: 35897672 Free PMC article. Review.
C-reactive protein (CRP) is considered a biomarker of infection/inflammation. It is a commonly used tool for early detection of infection in the emergency room or as a point-of-care test and especially for differentiating between bacterial and viral infections, affecting d …
C-reactive protein (CRP) is considered a biomarker of infection/inflammation. It is a commonly used tool for early detection of infec …
Fit-for-purpose method development and validation for successful biomarker measurement.
Lee JW, Devanarayan V, Barrett YC, Weiner R, Allinson J, Fountain S, Keller S, Weinryb I, Green M, Duan L, Rogers JA, Millham R, O'Brien PJ, Sailstad J, Khan M, Ray C, Wagner JA. Lee JW, et al. Pharm Res. 2006 Feb;23(2):312-28. doi: 10.1007/s11095-005-9045-3. Epub 2006 Jan 12. Pharm Res. 2006. PMID: 16397743
Still, widespread adoption of biomarkers is impeded by limited experience interpreting biomarker data and an unclear regulatory climate. ...Sample analysis within this context of fit-for-purpose method development and validation are well suited for successful bio …
Still, widespread adoption of biomarkers is impeded by limited experience interpreting biomarker data and an unclear regulator …
Biomarker assay validation.
Piccoli SP, Garofolo F. Piccoli SP, et al. Bioanalysis. 2018 Jun 1;10(12):889-891. doi: 10.4155/bio-2018-0127. Bioanalysis. 2018. PMID: 29939799 Free article. No abstract available.
Biomarker-based trials in neuro-oncology.
Ballman KV. Ballman KV. Chin Clin Oncol. 2015 Sep;4(3):38. doi: 10.3978/j.issn.2304-3865.2015.09.04. Chin Clin Oncol. 2015. PMID: 26408305 Free article. Review.
Treatment of brain tumors is increasingly informed by biomarkers. One use is to appropriately group tumors with similar genetic/genomic characteristics and to design trials separately for the individual groups. The biomarker's use is to predict patient respon …
Treatment of brain tumors is increasingly informed by biomarkers. One use is to appropriately group tumors with similar genetic/genom …
Advances in urinary biomarker discovery in urological research.
Kim J, Kim WT, Kim WJ. Kim J, et al. Investig Clin Urol. 2020 Feb;61(Suppl 1):S8-S22. doi: 10.4111/icu.2020.61.S1.S8. Epub 2019 Dec 31. Investig Clin Urol. 2020. PMID: 32055750 Free PMC article. Review.
A disease-specific biomarker (or biomarkers) is a characteristic reflecting a pathological condition in human body, which can be used as a diagnostic or prognostic tool for the clinical management. A urine-based biomarker(s) may provide a clinical valu …
A disease-specific biomarker (or biomarkers) is a characteristic reflecting a pathological condition in human body, which can …
Lipidomics and Biomarker Discovery in Kidney Disease.
Afshinnia F, Rajendiran TM, Wernisch S, Soni T, Jadoon A, Karnovsky A, Michailidis G, Pennathur S. Afshinnia F, et al. Semin Nephrol. 2018 Mar;38(2):127-141. doi: 10.1016/j.semnephrol.2018.01.004. Semin Nephrol. 2018. PMID: 29602396 Free PMC article. Review.
In this review, we describe the workflow commonly applied to the conduct of lipidomic studies including important aspects of study design, sample preparation, biomarker identification and quantification, and data processing and analysis, as well as crucial considerations i …
In this review, we describe the workflow commonly applied to the conduct of lipidomic studies including important aspects of study design, s …
Biomarkers-A General Review.
Aronson JK, Ferner RE. Aronson JK, et al. Curr Protoc Pharmacol. 2017 Mar 17;76:9.23.1-9.23.17. doi: 10.1002/cpph.19. Curr Protoc Pharmacol. 2017. PMID: 28306150 Review.
A biomarker is a biological observation that substitutes for and ideally predicts a clinically relevant endpoint or intermediate outcome that is more difficult to observe. The use of clinical biomarkers is easier and less expensive than direct measurement of the fin …
A biomarker is a biological observation that substitutes for and ideally predicts a clinically relevant endpoint or intermediate outc …
Computer-aided biomarker discovery for precision medicine: data resources, models and applications.
Lin Y, Qian F, Shen L, Chen F, Chen J, Shen B. Lin Y, et al. Brief Bioinform. 2019 May 21;20(3):952-975. doi: 10.1093/bib/bbx158. Brief Bioinform. 2019. PMID: 29194464 Review.
In this review, the concept and characteristics of typical biomarker types, e.g. single molecular biomarkers, module/network biomarkers, cross-level biomarkers, etc., are explicated on the guidance of systems biology. Then, publicly available data reso …
In this review, the concept and characteristics of typical biomarker types, e.g. single molecular biomarkers, module/network …
Glycan biomarker discovery.
Pierce M, Taniguchi N. Pierce M, et al. Proteomics Clin Appl. 2013 Oct;7(9-10):595-6. doi: 10.1002/prca.201370054. Proteomics Clin Appl. 2013. PMID: 26036234 No abstract available.
Biomarker Assay Validation by Mass Spectrometry.
Fernández-Metzler C, Ackermann B, Garofolo F, Arnold ME, DeSilva B, Gu H, Laterza O, Mao Y, Rose M, Vazvaei-Smith F, Steenwyk R. Fernández-Metzler C, et al. AAPS J. 2022 May 9;24(3):66. doi: 10.1208/s12248-022-00707-z. AAPS J. 2022. PMID: 35534647
Several papers have been published offering recommendations for biomarker assay validation. The situational nature of biomarker applications necessitates fit-for-purpose (FFP) assay validation. A unifying theme for FFP analysis is that method validation requirements …
Several papers have been published offering recommendations for biomarker assay validation. The situational nature of biomarker …
Periostin: A Potential Biomarker and Therapeutic Target in Pulmonary Diseases.
Alzobaidi N, Rehman S, Naqvi M, Gulati K, Ray A. Alzobaidi N, et al. J Pharm Pharm Sci. 2022;25:137-148. doi: 10.18433/jpps32306. J Pharm Pharm Sci. 2022. PMID: 35379385 Free article. Review.
This review highlights the potential role of periostin as a validated biomarker in respiratory disease progression and its candidacy to predict the response to treatments targeting Th-2 cytokines in bronchial asthma. ...Keywords Periostin, Asthma, Pneumonia, COPD, Idiopath …
This review highlights the potential role of periostin as a validated biomarker in respiratory disease progression and its candidacy …
Biomarker-Guided Adaptive Trial Designs in Phase II and Phase III: A Methodological Review.
Antoniou M, Jorgensen AL, Kolamunnage-Dona R. Antoniou M, et al. PLoS One. 2016 Feb 24;11(2):e0149803. doi: 10.1371/journal.pone.0149803. eCollection 2016. PLoS One. 2016. PMID: 26910238 Free PMC article. Review.
A number of clinical trial designs have been proposed for testing a biomarker's clinical utility, including Phase II and Phase III clinical trials which aim to test the effectiveness of a biomarker-guided approach to treatment; these designs can be broadly cl …
A number of clinical trial designs have been proposed for testing a biomarker's clinical utility, including Phase II and Phase …
Advances in biomarker detection: Alternative approaches for blood-based biomarker detection.
Rosado M, Silva R, G Bexiga M, G Jones J, Manadas B, Anjo SI. Rosado M, et al. Adv Clin Chem. 2019;92:141-199. doi: 10.1016/bs.acc.2019.04.003. Epub 2019 Jun 10. Adv Clin Chem. 2019. PMID: 31472753 Review.
In the clinical setting, a blood sample is typically the starting point for biomarker search and discovery. Mass spectrometry (MS) is a highly sensitive and informative method for characterizing a very wide range of metabolites and proteins and is therefore a potentially p …
In the clinical setting, a blood sample is typically the starting point for biomarker search and discovery. Mass spectrometry (MS) is …
Biomarkers of Bronchial Asthma.
Kunc P, Fabry J, Lucanska M, Pecova R. Kunc P, et al. Physiol Res. 2020 Mar 27;69(Suppl 1):S29-S34. doi: 10.33549/physiolres.934398. Physiol Res. 2020. PMID: 32228009 Free PMC article. Review.
An ideal biomarker should be suitable to identify the disease as well the specific endotype/phenotype, useful in the monitoring of the disease and to determine the prognosis, easily to obtain with minimum discomfort or risk to the patient - exhaled breath analysis, blood c …
An ideal biomarker should be suitable to identify the disease as well the specific endotype/phenotype, useful in the monitoring of th …
Proteomic Interrogation in Cancer Biomarker.
Kang UB. Kang UB. Adv Exp Med Biol. 2021;1187:305-322. doi: 10.1007/978-981-32-9620-6_15. Adv Exp Med Biol. 2021. PMID: 33983585
Biomarkers factor into the diagnosis and treatment of almost every patient with cancer. ...And, it is important for clinical, translational researchers to be acutely aware of the issues surrounding appropriate biomarker development, in order to facilitate entry of c …
Biomarkers factor into the diagnosis and treatment of almost every patient with cancer. ...And, it is important for clinical, transla …
Microfluidic platforms for biomarker analysis.
Nahavandi S, Baratchi S, Soffe R, Tang SY, Nahavandi S, Mitchell A, Khoshmanesh K. Nahavandi S, et al. Lab Chip. 2014 May 7;14(9):1496-514. doi: 10.1039/c3lc51124c. Epub 2014 Mar 25. Lab Chip. 2014. PMID: 24663505 Review.
Numerous factors contribute to the slow uptake of these new biomarkers, with challenges faced throughout the biomarker development pipeline. ...Indeed, adoption of microfluidics has provided a new avenue for advancement, promoting clinical utilisation of both bio …
Numerous factors contribute to the slow uptake of these new biomarkers, with challenges faced throughout the biomarker develop …
Application of comprehensive lipidomics to biomarker research on adverse drug reactions.
Saito K. Saito K. Drug Metab Pharmacokinet. 2021 Apr;37:100377. doi: 10.1016/j.dmpk.2020.100377. Epub 2021 Jan 14. Drug Metab Pharmacokinet. 2021. PMID: 33454388 Review.
Owing to their various functions, lipids are considered suitable targets for biomarker development; in addition, lipidomics analysis of adverse drug reactions (ADRs) has been conducted recently. ...In addition, novel biomarker candidates will be developed via classi …
Owing to their various functions, lipids are considered suitable targets for biomarker development; in addition, lipidomics analysis …
Proteomic-based biomarker discovery for development of next generation diagnostics.
Khalilpour A, Kilic T, Khalilpour S, Álvarez MM, Yazdi IK. Khalilpour A, et al. Appl Microbiol Biotechnol. 2017 Jan;101(2):475-491. doi: 10.1007/s00253-016-8029-z. Epub 2016 Dec 24. Appl Microbiol Biotechnol. 2017. PMID: 28013407 Review.
Thus, the identification of a "good" biomarker enables a more accurate early diagnosis and prognosis of disease. Rapid advancements in mass spectrometry (MS) instrumentation, liquid chromatography MS (LCMS), protein microarray technology, and other protein profiling method …
Thus, the identification of a "good" biomarker enables a more accurate early diagnosis and prognosis of disease. Rapid advancements i …
Sepsis biomarkers: a review.
Pierrakos C, Vincent JL. Pierrakos C, et al. Crit Care. 2010;14(1):R15. doi: 10.1186/cc8872. Epub 2010 Feb 9. Crit Care. 2010. PMID: 20144219 Free PMC article. Review.
METHODS: We used an electronic search of the PubMed database using the key words "sepsis" and "biomarker" to identify clinical and experimental studies which evaluated a biomarker in sepsis. RESULTS: The search retrieved 3370 references covering 178 different bio …
METHODS: We used an electronic search of the PubMed database using the key words "sepsis" and "biomarker" to identify clinical and ex …
[Biomarker in pulmonary diseases].
Gillissen A, Wiechmann V, Jürgens UR. Gillissen A, et al. Pneumologie. 2009 Aug;63(8):439-50. doi: 10.1055/s-0029-1214799. Epub 2009 Aug 7. Pneumologie. 2009. PMID: 19670103 Free article. Review. German.
Quantification of numerous markers in exhaled breath condensate or the detection of compounds in exhaled air are more recent attempts to further elucidate those biomarkers for clinical use. In general, biomarkers have an important supportive value in addition to rou …
Quantification of numerous markers in exhaled breath condensate or the detection of compounds in exhaled air are more recent attempts to fur …
Biomarkers of Aggressive Prostate Cancer at Diagnosis.
Boehm BE, York ME, Petrovics G, Kohaar I, Chesnut GT. Boehm BE, et al. Int J Mol Sci. 2023 Jan 22;24(3):2185. doi: 10.3390/ijms24032185. Int J Mol Sci. 2023. PMID: 36768533 Free PMC article. Review.
This fact, coupled with the criticism surrounding the role of prostate specific antigen in prostate cancer screening, demonstrates the current need for a biomarker(s) that can identify clinically significant CaP and avoid unnecessary biopsy procedures and psychologi …
This fact, coupled with the criticism surrounding the role of prostate specific antigen in prostate cancer screening, demonstrates the curre …
Complex network-based approaches to biomarker discovery.
Hayashida M, Akutsu T. Hayashida M, et al. Biomark Med. 2016 Jun;10(6):621-32. doi: 10.2217/bmm-2015-0047. Epub 2016 Mar 7. Biomark Med. 2016. PMID: 26947205 Review.
Many studies on biomarker discovery have been done by analyzing mutations in DNA sequences and differences in gene expression patterns. ...Furthermore, network biomarkers have been extended to dynamical network biomarkers, in which time series expression data …
Many studies on biomarker discovery have been done by analyzing mutations in DNA sequences and differences in gene expression pattern …
Toward an integrated pipeline for protein biomarker development.
Drabovich AP, Martínez-Morillo E, Diamandis EP. Drabovich AP, et al. Biochim Biophys Acta. 2015 Jun;1854(6):677-86. doi: 10.1016/j.bbapap.2014.09.006. Epub 2014 Sep 11. Biochim Biophys Acta. 2015. PMID: 25218201 Review.
Protein biomarker development is a multidisciplinary task involving basic, translational and clinical research. Integration of multidisciplinary efforts in a single pipeline is challenging, but crucial to facilitate rational discovery of protein biomarkers and allev …
Protein biomarker development is a multidisciplinary task involving basic, translational and clinical research. Integration of multid …
Biomarker discovery in transplantation--proteomic adventure or mission impossible?
Kienzl-Wagner K, Pratschke J, Brandacher G. Kienzl-Wagner K, et al. Clin Biochem. 2013 Apr;46(6):497-505. doi: 10.1016/j.clinbiochem.2012.10.010. Epub 2012 Oct 23. Clin Biochem. 2013. PMID: 23089107 Review.
Optimal management of transplanted organs requires specific and sensitive biomarkers for immunologic graft monitoring and subsequently patient tailored treatment. Proteomic science has emerged as an attractive tool in clinical biomarker research generating massive a …
Optimal management of transplanted organs requires specific and sensitive biomarkers for immunologic graft monitoring and subsequentl …
Biomarkers and biomarker validation: a pathologist's guide to getting it right.
Paver EC, Morey AL. Paver EC, et al. Pathology. 2024 Mar;56(2):147-157. doi: 10.1016/j.pathol.2023.11.002. Epub 2023 Dec 12. Pathology. 2024. PMID: 38195376 Review.
Therefore, it is important that pathologists have a solid understanding of how biomarkers are developed, the process of biomarker validation, how new biomarkers are approved for clinical use and the potential issues around implementation of biomarker t …
Therefore, it is important that pathologists have a solid understanding of how biomarkers are developed, the process of biomarker …
Biomarker enrichment strategies: matching trial design to biomarker credentials.
Freidlin B, Korn EL. Freidlin B, et al. Nat Rev Clin Oncol. 2014 Feb;11(2):81-90. doi: 10.1038/nrclinonc.2013.218. Epub 2013 Nov 26. Nat Rev Clin Oncol. 2014. PMID: 24281059 Review.
The development of targeted agents and their accompanying biomarkers frequently occurs contemporaneously, and confidence in a putative biomarker's performance might, therefore, be insufficient to restrict the definitive testing of a new agent to the subgroup …
The development of targeted agents and their accompanying biomarkers frequently occurs contemporaneously, and confidence in a putativ …
Biomarker discovery: validation and decision-making in product development.
Niedbala RS, Mauck C, Harrison P, Doncel GF. Niedbala RS, et al. Sex Transm Dis. 2009 Mar;36(3 Suppl):S76-80. doi: 10.1097/OLQ.0b013e31819cd800. Sex Transm Dis. 2009. PMID: 19218888 Review.
The experiences discussed ranged from de novo discovery of new therapeutics to qualification of biomarkers across all stages of development, and covered the complexity of biomarker identification, use, and assessment in the clinical areas of cancer and infectious di …
The experiences discussed ranged from de novo discovery of new therapeutics to qualification of biomarkers across all stages of devel …
Better cancer biomarker discovery through better study design.
Rundle A, Ahsan H, Vineis P. Rundle A, et al. Eur J Clin Invest. 2012 Dec;42(12):1350-9. doi: 10.1111/j.1365-2362.2012.02727.x. Epub 2012 Sep 23. Eur J Clin Invest. 2012. PMID: 22998109 Free PMC article. Review.
METHODS: We review principles for nested case-control study design in relation to biomarker discovery studies and describe how the efficiency of biomarker discovery can be effected by study design choices. ...CONCLUSIONS: For a valid, but as yet undiscovered, bio …
METHODS: We review principles for nested case-control study design in relation to biomarker discovery studies and describe how the ef …
Biomarkers in acute kidney injury - pathophysiological basis and clinical performance.
Schrezenmeier EV, Barasch J, Budde K, Westhoff T, Schmidt-Ott KM. Schrezenmeier EV, et al. Acta Physiol (Oxf). 2017 Mar;219(3):554-572. doi: 10.1111/apha.12764. Epub 2016 Aug 25. Acta Physiol (Oxf). 2017. PMID: 27474473 Free PMC article. Review.
Various biomarkers of acute kidney injury (AKI) have been discovered and characterized in the recent past. ...We also acknowledge each biomarker's advantages and disadvantages as well as important knowledge gaps and perspectives for future studies....
Various biomarkers of acute kidney injury (AKI) have been discovered and characterized in the recent past. ...We also acknowledge eac …
High-sensitivity nanosensors for biomarker detection.
Swierczewska M, Liu G, Lee S, Chen X. Swierczewska M, et al. Chem Soc Rev. 2012 Apr 7;41(7):2641-55. doi: 10.1039/c1cs15238f. Epub 2011 Dec 20. Chem Soc Rev. 2012. PMID: 22187721 Free PMC article. Review.
High sensitivity nanosensors utilize optical, mechanical, electrical, and magnetic relaxation properties to push detection limits of biomarkers below previously possible concentrations. The unique properties of nanomaterials and nanotechnology are exploited to design bi …
High sensitivity nanosensors utilize optical, mechanical, electrical, and magnetic relaxation properties to push detection limits of biom …
Biomarkers in autism spectrum disorders: Current progress.
Shen L, Liu X, Zhang H, Lin J, Feng C, Iqbal J. Shen L, et al. Clin Chim Acta. 2020 Mar;502:41-54. doi: 10.1016/j.cca.2019.12.009. Epub 2019 Dec 16. Clin Chim Acta. 2020. PMID: 31857069 Review.
As the etiology and pathogenesis of the disorder have not yet been elucidated, specific treatment and reliable diagnostic biomarkers are not available. Early behavioral interventions have been shown to substantially improve symptoms in children with ASD. Given the rapidly …
As the etiology and pathogenesis of the disorder have not yet been elucidated, specific treatment and reliable diagnostic biomarkers …
Recent Advances and Challenges in Steroid Metabolomics for Biomarker Discovery.
Kotłowska A, Szefer P. Kotłowska A, et al. Curr Med Chem. 2019;26(1):29-45. doi: 10.2174/0929867324666171113120810. Curr Med Chem. 2019. PMID: 29141530 Review.
The combination of hyphenated techniques and pattern recognition methods allows to carry out a comprehensive assessment of the slightest alterations in steroid metabolic pathways and can be applied as a tool for biomarker discovery. METHODS: We have performed an extensive …
The combination of hyphenated techniques and pattern recognition methods allows to carry out a comprehensive assessment of the slightest alt …
Sources of variability in biomarker concentrations.
Aylward LL, Hays SM, Smolders R, Koch HM, Cocker J, Jones K, Warren N, Levy L, Bevan R. Aylward LL, et al. J Toxicol Environ Health B Crit Rev. 2014;17(1):45-61. doi: 10.1080/10937404.2013.864250. J Toxicol Environ Health B Crit Rev. 2014. PMID: 24597909 Review.
The accurate use of biomonitoring as an exposure characterization tool requires understanding of factors, apart from external exposure level, that influence variation in biomarker concentrations. This review provides an overview of factors that might influence inter- and i …
The accurate use of biomonitoring as an exposure characterization tool requires understanding of factors, apart from external exposure level …
Quantitation with chemical tagging reagents in biomarker studies.
Westbrook JA, Noirel J, Brown JE, Wright PC, Evans CA. Westbrook JA, et al. Proteomics Clin Appl. 2015 Apr;9(3-4):295-300. doi: 10.1002/prca.201400120. Epub 2015 Feb 10. Proteomics Clin Appl. 2015. PMID: 25504339 Review.
In this Viewpoint article, applications for discovery and targeted modes are discussed with an emphasis on study design and technical considerations in biomarker analysis. The evolution and promise of emerging, related strategies are also discussed. It should be noted that …
In this Viewpoint article, applications for discovery and targeted modes are discussed with an emphasis on study design and technical consid …
Graphene-based protein biomarker detection.
Patil AV, Fernandes FB, Bueno PR, Davis JJ. Patil AV, et al. Bioanalysis. 2015;7(6):725-42. doi: 10.4155/bio.15.4. Bioanalysis. 2015. PMID: 25871589 Review.
An ability to detect and quantify protein molecules, harbingers of specific pathologies, potentially underpins both early disease diagnosis and an assessment of treatment efficacy. However, the specific detection of a particular protein biomarker in a complex environment i …
An ability to detect and quantify protein molecules, harbingers of specific pathologies, potentially underpins both early disease diagnosis …
Elevating pancreatic cystic lesion stratification: Current and future pancreatic cancer biomarker(s).
Carmicheal J, Patel A, Dalal V, Atri P, Dhaliwal AS, Wittel UA, Malafa MP, Talmon G, Swanson BJ, Singh S, Jain M, Kaur S, Batra SK. Carmicheal J, et al. Biochim Biophys Acta Rev Cancer. 2020 Jan;1873(1):188318. doi: 10.1016/j.bbcan.2019.188318. Epub 2019 Oct 30. Biochim Biophys Acta Rev Cancer. 2020. PMID: 31676330 Free PMC article. Review.
There continues to be a need for accurate molecular and imaging biomarker(s) capable of identifying malignant PCLs and predicting the malignant potential of PCLs to enable risk stratification and effective intervention management. This review provides an update on t …
There continues to be a need for accurate molecular and imaging biomarker(s) capable of identifying malignant PCLs and predict …
Neuropsychiatric biomarker discovery: go big or go home.
Ljungdahl A, Sanders SJ. Ljungdahl A, et al. Trends Mol Med. 2023 Nov;29(11):878-879. doi: 10.1016/j.molmed.2023.09.002. Epub 2023 Sep 14. Trends Mol Med. 2023. PMID: 37714797 Free PMC article.
Technological advances have enabled high-throughput omics assays, such as parallelized screening of lipids across plasma samples. Pioneering a new paradigm for neuropsychiatric biomarker discovery, Yap et al. describe a large-scale systematic analysis of comprehensive phen …
Technological advances have enabled high-throughput omics assays, such as parallelized screening of lipids across plasma samples. Pioneering …
Biomarker research with prospective study designs for the early detection of cancer.
Pesch B, Brüning T, Johnen G, Casjens S, Bonberg N, Taeger D, Müller A, Weber DG, Behrens T. Pesch B, et al. Biochim Biophys Acta. 2014 May;1844(5):874-83. doi: 10.1016/j.bbapap.2013.12.007. Epub 2013 Dec 17. Biochim Biophys Acta. 2014. PMID: 24361552 Review.
Randomized controlled trials have the highest level of evidence in assessing a biomarker's benefit against usual care and present the most stringent design for the validation of promising markers as well as for the discovery of new markers. In summary, all kinds of …
Randomized controlled trials have the highest level of evidence in assessing a biomarker's benefit against usual care and pres …
Current technological challenges in biomarker discovery and validation.
Horvatovich PL, Bischoff R. Horvatovich PL, et al. Eur J Mass Spectrom (Chichester). 2010;16(1):101-21. doi: 10.1255/ejms.1050. Eur J Mass Spectrom (Chichester). 2010. PMID: 20065518 Review.
Biomarker discovery is based on a close collaboration between clinicians, analytical scientists and chemometritians/statisticians. It is critical to define the final purpose of a biomarker or biomarker pattern at the onset of the study and to select case and …
Biomarker discovery is based on a close collaboration between clinicians, analytical scientists and chemometritians/statisticians. It …
Targeted metabolomics for biomarker discovery.
Griffiths WJ, Koal T, Wang Y, Kohl M, Enot DP, Deigner HP. Griffiths WJ, et al. Angew Chem Int Ed Engl. 2010 Jul 26;49(32):5426-45. doi: 10.1002/anie.200905579. Angew Chem Int Ed Engl. 2010. PMID: 20629054 Review.
Metabolomics is a truly interdisciplinary field of science, which combines analytical chemistry, platform technology, mass spectrometry, and NMR spectroscopy with sophisticated data analysis. Applied to biomarker discovery, it includes aspects of pathobiochemistry, systems …
Metabolomics is a truly interdisciplinary field of science, which combines analytical chemistry, platform technology, mass spectrometry, and …
Glycan microarrays: powerful tools for biomarker discovery.
Muthana SM, Gildersleeve JC. Muthana SM, et al. Cancer Biomark. 2014 Jan 1;14(1):29-41. doi: 10.3233/CBM-130383. Cancer Biomark. 2014. PMID: 24643040 Review.
More recently, this technology has been applied to the discovery of biomarkers for diagnosis, prognosis, risk prediction, and monitoring immune responses. ...Herein, we review efforts to use glycan arrays to identify new biomarkers for cancer, infections, autoimmune …
More recently, this technology has been applied to the discovery of biomarkers for diagnosis, prognosis, risk prediction, and monitor …
Stable feature selection for biomarker discovery.
He Z, Yu W. He Z, et al. Comput Biol Chem. 2010 Aug;34(4):215-25. doi: 10.1016/j.compbiolchem.2010.07.002. Epub 2010 Aug 10. Comput Biol Chem. 2010. PMID: 20702140 Review.
Feature selection techniques have been used as the workhorse in biomarker discovery applications for a long time. Surprisingly, the stability of feature selection with respect to sampling variations has long been under-considered. ...In this article, we review existing sta …
Feature selection techniques have been used as the workhorse in biomarker discovery applications for a long time. Surprisingly, the s …
Delivery of high-quality biomarker assays.
Swanson BN. Swanson BN. Dis Markers. 2002;18(2):47-56. doi: 10.1155/2002/212987. Dis Markers. 2002. PMID: 12364810 Free PMC article. Review.
While most research applications of biomarkers are not regulated, biomarker laboratories in all settings are adopting similar laboratory practices in order to deliver high-quality data. Because of the escalation in demand for biomarker measurements, the highl …
While most research applications of biomarkers are not regulated, biomarker laboratories in all settings are adopting similar …
Metabolomics and cardiovascular biomarker discovery.
Rhee EP, Gerszten RE. Rhee EP, et al. Clin Chem. 2012 Jan;58(1):139-47. doi: 10.1373/clinchem.2011.169573. Epub 2011 Nov 22. Clin Chem. 2012. PMID: 22110018 Free PMC article. Review.
To this end, metabolite profiling has been applied to human biomarker discovery in small-scale interventions, in which individuals are extremely well phenotyped and able to serve as their own biological controls, as well as in larger epidemiological cohorts. ...Experimenta …
To this end, metabolite profiling has been applied to human biomarker discovery in small-scale interventions, in which individuals ar …
Biomarker research in prostate cancer--towards utility, not futility.
Oon SF, Pennington SR, Fitzpatrick JM, Watson RW. Oon SF, et al. Nat Rev Urol. 2011 Mar;8(3):131-8. doi: 10.1038/nrurol.2011.11. Nat Rev Urol. 2011. PMID: 21394176 Review.
The identification of an appropriate clinical question is critical for any biomarker project. Despite rapid advances in technology, few biomarkers have been forthcoming for prostate cancer. ...In this Review, we have developed a prostate cancer 'roadmap' to identify …
The identification of an appropriate clinical question is critical for any biomarker project. Despite rapid advances in technology, f …
Strategic paths for biomarker qualification.
Goodsaid FM, Frueh FW, Mattes W. Goodsaid FM, et al. Toxicology. 2008 Mar 20;245(3):219-23. doi: 10.1016/j.tox.2007.12.023. Epub 2008 Jan 6. Toxicology. 2008. PMID: 18280028 Review.
Biomarkers may be qualified using different qualification processes. A passive approach for qualification has been to accept the end of discussions in the scientific literature as an indication that a biomarker has been accepted. An active approach to qualification …
Biomarkers may be qualified using different qualification processes. A passive approach for qualification has been to accept the end …
Biochemistry, Therapeutics, and Biomarker Implications of Neprilysin in Cardiorenal Disease.
Chen Y, Burnett JC Jr. Chen Y, et al. Clin Chem. 2017 Jan;63(1):108-115. doi: 10.1373/clinchem.2016.262907. Epub 2016 Nov 15. Clin Chem. 2017. PMID: 28062615 Free PMC article. Review.
Finally, monitoring BNP/NT-proBNP/cGMP concentrations during NEP inhibition treatment may provide supplemental benefits to conventional biomarkers, and the identification of soluble NEP as a novel biomarker for HF needs further investigation. ...Moreover, the discov …
Finally, monitoring BNP/NT-proBNP/cGMP concentrations during NEP inhibition treatment may provide supplemental benefits to conventional b …
Motor neuron disease: biomarker development for an expanding cerebral syndrome.
Turner MR. Turner MR. Clin Med (Lond). 2016 Dec;16(Suppl 6):s60-s65. doi: 10.7861/clinmedicine.16-6-s60. Clin Med (Lond). 2016. PMID: 27956443 Free PMC article. Review.
With new genetic causes, most notably a hexanucleotide expansion in C9orf72 associated with both MND and FTD, the development of biomarkers against which to test therapeutic candidates is a priority....
With new genetic causes, most notably a hexanucleotide expansion in C9orf72 associated with both MND and FTD, the development of biomarke …
Proteomic-driven biomarker discovery in gestational diabetes mellitus: a review.
Singh A, Subramani E, Datta Ray C, Rapole S, Chaudhury K. Singh A, et al. J Proteomics. 2015 Sep 8;127(Pt A):44-9. doi: 10.1016/j.jprot.2015.07.020. Epub 2015 Jul 26. J Proteomics. 2015. PMID: 26216595 Review.
Given the fact that the progress of a successful pregnancy is dependent on the intricate communication between several biological molecules, identification of the proteomic profile perturbations in women with GDM is expected to help in understanding the disease pathogenesis and a …
Given the fact that the progress of a successful pregnancy is dependent on the intricate communication between several biological molecules, …
Association between an inflammatory biomarker score and future dementia diagnosis in the population-based UK Biobank cohort of 500,000 people.
Mekli K, Lophatananon A, Maharani A, Nazroo JY, Muir KR. Mekli K, et al. PLoS One. 2023 Jul 19;18(7):e0288045. doi: 10.1371/journal.pone.0288045. eCollection 2023. PLoS One. 2023. PMID: 37467176 Free PMC article.
We also assessed the same biomarker's association with dementia diagnosis 3-11 years later in the initially dementia-free sample. ...Finally, the highest biomarker quartile was significantly associated with increased dementia risk compared to the lowest quart …
We also assessed the same biomarker's association with dementia diagnosis 3-11 years later in the initially dementia-free samp …
Recent progress toward biomarker identification in osteoarthritis.
De Ceuninck F, Sabatini M, Pastoureau P. De Ceuninck F, et al. Drug Discov Today. 2011 May;16(9-10):443-9. doi: 10.1016/j.drudis.2011.01.004. Epub 2011 Jan 22. Drug Discov Today. 2011. PMID: 21262380 Review.
This clinical heterogeneity complicates the identification of biomarkers that are crucial for prompt pharmacological intervention at the early stages of the disease and for monitoring treatment efficacy with higher sensitivity than existing imaging methods. In this review, …
This clinical heterogeneity complicates the identification of biomarkers that are crucial for prompt pharmacological intervention at …
Exosome analysis: a promising biomarker system with special attention to saliva.
Zheng X, Chen F, Zhang J, Zhang Q, Lin J. Zheng X, et al. J Membr Biol. 2014 Nov;247(11):1129-36. doi: 10.1007/s00232-014-9717-1. Epub 2014 Aug 19. J Membr Biol. 2014. PMID: 25135166 Review.
Recently, three scientists won the Nobel Prize for determining the mechanisms of exosomal transport, making exosomes a promising biomarker system for disease diagnosis and treatment. This review provides a general introduction of exosomes and explores the recent progress o …
Recently, three scientists won the Nobel Prize for determining the mechanisms of exosomal transport, making exosomes a promising biomarke …
Advances in proteomic prostate cancer biomarker discovery.
Goo YA, Goodlett DR. Goo YA, et al. J Proteomics. 2010 Sep 10;73(10):1839-50. doi: 10.1016/j.jprot.2010.04.002. Epub 2010 Apr 14. J Proteomics. 2010. PMID: 20398807 Review.
Thus, the identification of a biomarker(s) that can complement or replace PSA represents a major goal for prostate cancer research. ...Additionally, we review recent developments in validation of putative markers, efforts at systems biology approach, and current cha …
Thus, the identification of a biomarker(s) that can complement or replace PSA represents a major goal for prostate cancer rese …
Salivary DNA Methylation Profiling: Aspects to Consider for Biomarker Identification.
Langie SAS, Moisse M, Declerck K, Koppen G, Godderis L, Vanden Berghe W, Drury S, De Boever P. Langie SAS, et al. Basic Clin Pharmacol Toxicol. 2017 Sep;121 Suppl 3(Suppl Suppl 3):93-101. doi: 10.1111/bcpt.12721. Epub 2017 Feb 10. Basic Clin Pharmacol Toxicol. 2017. PMID: 27901320 Free PMC article. Review.
Knowledge gaps will be identified and suggestions given on how to improve the analysis, making saliva 'the' biofluid of choice for future biomarker initiatives in many different epidemiological and public health studies....
Knowledge gaps will be identified and suggestions given on how to improve the analysis, making saliva 'the' biofluid of choice for future …
Pregnancy-Specific beta1-Glycoproteins: Combined Biomarker Roles, Structure/Function Relationships and Implications for Drug Design.
Moldogazieva NT, Mokhosoev IM, Terentiev AA. Moldogazieva NT, et al. Curr Med Chem. 2017;24(3):245-267. doi: 10.2174/0929867324666161123090554. Curr Med Chem. 2017. PMID: 27881070 Review.
METHODS: Literature search was performed to review the majority of recent PSG studies with emphasis on usage of high-throughput integrated proteomic profiling technologies, systems biology and bioinformatics approaches that enhance novel biomarker and drug target discovery …
METHODS: Literature search was performed to review the majority of recent PSG studies with emphasis on usage of high-throughput integrated p …
Targeted mass spectrometry approaches for protein biomarker verification.
Meng Z, Veenstra TD. Meng Z, et al. J Proteomics. 2011 Nov 18;74(12):2650-9. doi: 10.1016/j.jprot.2011.04.011. Epub 2011 Apr 21. J Proteomics. 2011. PMID: 21540133 Review.
The search for protein biomarkers has been a highly pursued topic in the proteomics community in the last decade. ...The recent development of proteomic technologies including the advancement of mass spectrometers with high sensitivity and speed has greatly advanced the di …
The search for protein biomarkers has been a highly pursued topic in the proteomics community in the last decade. ...The recent devel …
Ectopic pregnancy: search for biomarker in salivary proteome.
Priya Aarthy A, Sen S, Srinivasan M, Muthukumar S, Madhanraj P, Akbarsha MA, Archunan G. Priya Aarthy A, et al. Sci Rep. 2023 Oct 6;13(1):16828. doi: 10.1038/s41598-023-43791-7. Sci Rep. 2023. PMID: 37803047 Free PMC article.
Glutathione-S-transferase omega-1 (GSTO1) is specific for EPR and has been reported as a candidate biomarker in the serum of EPR patients. Therefore, saliva would be a potential source of diagnostic non-invasive protein biomarker(s) for EP. Intensive investig …
Glutathione-S-transferase omega-1 (GSTO1) is specific for EPR and has been reported as a candidate biomarker in the serum of EPR pati …
Potential contribution of ELISA and LFI assays to assessment of the oxidative stress condition based on 8-oxodG biomarker.
Mello LD. Mello LD. Anal Biochem. 2021 Sep 1;628:114215. doi: 10.1016/j.ab.2021.114215. Epub 2021 May 3. Anal Biochem. 2021. PMID: 33957135 Review.
Over the past years, the application of these methods has been extended to assess the clinical oxidative stress condition based on monitoring of the 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) biomarker levels. The present manuscript provides an overview of the current i …
Over the past years, the application of these methods has been extended to assess the clinical oxidative stress condition based on monitorin …
Stable-isotope dilution LC-MS for quantitative biomarker analysis.
Ciccimaro E, Blair IA. Ciccimaro E, et al. Bioanalysis. 2010 Feb;2(2):311-41. doi: 10.4155/bio.09.185. Bioanalysis. 2010. PMID: 20352077 Free PMC article. Review.
The ability to conduct validated analyses of biomarkers is critically important in order to establish the sensitivity and selectivity of the biomarker in identifying a particular disease. ...This methodology is now widely used in the discovery and validation of puta …
The ability to conduct validated analyses of biomarkers is critically important in order to establish the sensitivity and selectivity …
Metabolomics analysis for biomarker discovery: advances and challenges.
Monteiro MS, Carvalho M, Bastos ML, Guedes de Pinho P. Monteiro MS, et al. Curr Med Chem. 2013;20(2):257-71. doi: 10.2174/092986713804806621. Curr Med Chem. 2013. PMID: 23210853 Review.
Compared to classical diagnostic approaches and conventional clinical biomarkers, metabolomics offers potential advantages in sensitivity and specificity. ...This review will provide an insight to the characteristics, strengths, limitations, and recent advances in metabolo …
Compared to classical diagnostic approaches and conventional clinical biomarkers, metabolomics offers potential advantages in sensiti …
STRATEGIES AND CHALLENGES IN METHOD DEVELOPMENT AND VALIDATION FOR THE ABSOLUTE QUANTIFICATION OF ENDOGENOUS BIOMARKER METABOLITES USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY.
Khamis MM, Adamko DJ, El-Aneed A. Khamis MM, et al. Mass Spectrom Rev. 2021 Jan;40(1):31-52. doi: 10.1002/mas.21607. Epub 2019 Oct 15. Mass Spectrom Rev. 2021. PMID: 31617245 Review.
Such interruption in the biomarker qualification process can be largely attributed to various reasons including inappropriate study design and inadequate data to support the clinical utility of the biomarkers. In addition, the lack of robust assays for the routine q …
Such interruption in the biomarker qualification process can be largely attributed to various reasons including inappropriate study d …
Mass Spectrometry-Based Biomarker Discovery.
Zhou W, Petricoin EF 3rd, Longo C. Zhou W, et al. Methods Mol Biol. 2017;1606:297-311. doi: 10.1007/978-1-4939-6990-6_19. Methods Mol Biol. 2017. PMID: 28502008
The discovery of candidate biomarkers within the entire proteome is one of the most important and challenging goals in proteomic research. ...For mass spectrometry analysis, protein extractions from tissues or body fluids and subsequent protein fractionation represent an i …
The discovery of candidate biomarkers within the entire proteome is one of the most important and challenging goals in proteomic rese …
Multiplex assays for biomarker research and clinical application: translational science coming of age.
Fu Q, Schoenhoff FS, Savage WJ, Zhang P, Van Eyk JE. Fu Q, et al. Proteomics Clin Appl. 2010 Mar;4(3):271-84. doi: 10.1002/prca.200900217. Epub 2010 Jan 7. Proteomics Clin Appl. 2010. PMID: 21137048 Review.
Quantitative measurement of proteins is a critical step in biomarker discovery. Assessing a large number of potential protein biomarkers in a statistically significant number of samples and controls still constitutes a major technical hurdle. ...We also discuss choo …
Quantitative measurement of proteins is a critical step in biomarker discovery. Assessing a large number of potential protein biom …
MicroRNAs (miRNAs) as biomarker(s) for prognosis and diagnosis of gastrointestinal (GI) cancers.
Macha MA, Seshacharyulu P, Krishn SR, Pai P, Rachagani S, Jain M, Batra SK. Macha MA, et al. Curr Pharm Des. 2014;20(33):5287-97. doi: 10.2174/1381612820666140128213117. Curr Pharm Des. 2014. PMID: 24479799 Free PMC article. Review.
Major advancements have improved our understanding of pathology and pathogenesis of GI cancers, but high mortality rates, unfavorable prognosis and lack of clinical predictive biomarkers provide an impetus to investigate new sensitive and specific diagnostic and prognostic …
Major advancements have improved our understanding of pathology and pathogenesis of GI cancers, but high mortality rates, unfavorable progno …
Nonceliac gluten sensitivity.
Catassi C, Catassi G, Naspi L. Catassi C, et al. Curr Opin Clin Nutr Metab Care. 2023 Sep 1;26(5):490-494. doi: 10.1097/MCO.0000000000000925. Epub 2023 Feb 15. Curr Opin Clin Nutr Metab Care. 2023. PMID: 36942921 Free PMC article. Review.
Self-reported NCWS is very common worldwide, particularly in patients seen at the gastroenterology clinic, but many of these diagnoses are not confirmed by standard clinical criteria. A biomarker of NCWS is still lacking, however, subtle histological features at the small …
Self-reported NCWS is very common worldwide, particularly in patients seen at the gastroenterology clinic, but many of these diagnoses are n …
High-content affinity-based proteomics: unlocking protein biomarker discovery.
Brody EN, Gold L, Lawn RM, Walker JJ, Zichi D. Brody EN, et al. Expert Rev Mol Diagn. 2010 Nov;10(8):1013-22. doi: 10.1586/erm.10.89. Expert Rev Mol Diagn. 2010. PMID: 21080818 Review.
Single protein biomarkers measured with antibody-based affinity assays are the basis of molecular diagnostics in clinical practice today. There is great hope in discovering new protein biomarkers and combinations of protein biomarkers for advancing medicine t …
Single protein biomarkers measured with antibody-based affinity assays are the basis of molecular diagnostics in clinical practice to …
Application of 'omics technologies to biomarker discovery in inflammatory lung diseases.
Wheelock CE, Goss VM, Balgoma D, Nicholas B, Brandsma J, Skipp PJ, Snowden S, Burg D, D'Amico A, Horvath I, Chaiboonchoe A, Ahmed H, Ballereau S, Rossios C, Chung KF, Montuschi P, Fowler SJ, Adcock IM, Postle AD, Dahlén SE, Rowe A, Sterk PJ, Auffray C, Djukanovic R; U-BIOPRED Study Group. Wheelock CE, et al. Eur Respir J. 2013 Sep;42(3):802-25. doi: 10.1183/09031936.00078812. Epub 2013 Feb 8. Eur Respir J. 2013. PMID: 23397306 Free article. Review.
Sophisticated large-scale analytical methods to quantify gene expression (transcriptomics), proteins (proteomics), lipids (lipidomics) and metabolites (metabolomics) in the lungs, blood and urine are now available to identify biomarkers that define disease in terms of comb …
Sophisticated large-scale analytical methods to quantify gene expression (transcriptomics), proteins (proteomics), lipids (lipidomics) and m …
Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future.
Good DM, Thongboonkerd V, Novak J, Bascands JL, Schanstra JP, Coon JJ, Dominiczak A, Mischak H. Good DM, et al. J Proteome Res. 2007 Dec;6(12):4549-55. doi: 10.1021/pr070529w. Epub 2007 Oct 31. J Proteome Res. 2007. PMID: 17970587 Review.
Sparked by the article from Lescuyer and colleagues in a recent issue, we aim here to further encourage interest in and discussion of clinically relevant biomarker research. We express our view on proteomics for biomarker discovery by addressing multiple relevant is …
Sparked by the article from Lescuyer and colleagues in a recent issue, we aim here to further encourage interest in and discussion of clinic …
Mass spectrometry-coupled techniques for viral-related disease biomarker identification.
Rhea JM, Diwan CA, Molinaro RJ. Rhea JM, et al. Biomark Med. 2010 Dec;4(6):859-70. doi: 10.2217/bmm.10.110. Biomark Med. 2010. PMID: 21133707 Review.
These advances have enabled a more comprehensive characterization of viral interactions involved in infection and pathogenesis, and allowed the discovery of viral biomarkers. This article focuses on the role of mass spectrometry proteomic techniques to identify and charact …
These advances have enabled a more comprehensive characterization of viral interactions involved in infection and pathogenesis, and allowed …
Immunoaffinity Mass Spectrometry Diagnostic Tests for Multi-Biomarker Assays.
Bringans S, Casey T, Ito J, Lumbantobing T, O'Neill R, Lipscombe R. Bringans S, et al. Methods Mol Biol. 2023;2628:195-206. doi: 10.1007/978-1-0716-2978-9_13. Methods Mol Biol. 2023. PMID: 36781787
A method has been developed to detect and quantify three protein biomarkers for a diabetic kidney disease prognostic assay, PromarkerD. ...Targeted mass spectrometry provides a quantitative measure of each biomarker in a rapid 8 min run using a microflow LCMS workfl …
A method has been developed to detect and quantify three protein biomarkers for a diabetic kidney disease prognostic assay, Promarker …
Optimal design for inference on the threshold of a biomarker.
Baldi Antognini A, Frieri R, Rosenberger WF, Zagoraiou M. Baldi Antognini A, et al. Stat Methods Med Res. 2024 Feb;33(2):321-343. doi: 10.1177/09622802231225964. Epub 2024 Jan 31. Stat Methods Med Res. 2024. PMID: 38297878
Enrichment designs with a continuous biomarker require the estimation of a threshold to determine the subpopulation benefitting from the treatment. This article provides the optimal allocation for inference in a two-stage enrichment design for treatment comparisons when a …
Enrichment designs with a continuous biomarker require the estimation of a threshold to determine the subpopulation benefitting from …
Comprehensive metabolic profiling of Parkinson's disease by liquid chromatography-mass spectrometry.
Shao Y, Li T, Liu Z, Wang X, Xu X, Li S, Xu G, Le W. Shao Y, et al. Mol Neurodegener. 2021 Jan 23;16(1):4. doi: 10.1186/s13024-021-00425-8. Mol Neurodegener. 2021. PMID: 33485385 Free PMC article.
Recently, unbiased metabolic profiling of human sample has been initiated to identify novel PD metabolic biomarkers and dysfunctional metabolic pathways, however, it remains a challenge to define reliable biomarker(s) for clinical use. ...Multiple linear regr …
Recently, unbiased metabolic profiling of human sample has been initiated to identify novel PD metabolic biomarkers and dysfunctional …
Using data-independent, high-resolution mass spectrometry in protein biomarker research: perspectives and clinical applications.
Sajic T, Liu Y, Aebersold R. Sajic T, et al. Proteomics Clin Appl. 2015 Apr;9(3-4):307-21. doi: 10.1002/prca.201400117. Epub 2015 Feb 23. Proteomics Clin Appl. 2015. PMID: 25504613 Review.
In medicine, there is an urgent need for protein biomarkers in a range of applications that includes diagnostics, disease stratification, and therapeutic decisions. One of the main technologies to address this need is MS, used for protein biomarker discovery and, in …
In medicine, there is an urgent need for protein biomarkers in a range of applications that includes diagnostics, disease stratificat …
Metabolomics in critical care medicine: a new approach to biomarker discovery.
Banoei MM, Donnelly SJ, Mickiewicz B, Weljie A, Vogel HJ, Winston BW. Banoei MM, et al. Clin Invest Med. 2014 Dec 1;37(6):E363-76. doi: 10.25011/cim.v37i6.22241. Clin Invest Med. 2014. PMID: 25618269 Review.
CONCLUSION: Metabolomics is a powerful tool that has strong potential to impact diagnosis and prognosis and to examine responses to treatment in critical care medicine through diagnostic and prognostic biomarker and biopattern identification....
CONCLUSION: Metabolomics is a powerful tool that has strong potential to impact diagnosis and prognosis and to examine responses to treatmen …
Multiple reaction monitoring for quantitative biomarker analysis in proteomics and metabolomics.
Kitteringham NR, Jenkins RE, Lane CS, Elliott VL, Park BK. Kitteringham NR, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 May 1;877(13):1229-39. doi: 10.1016/j.jchromb.2008.11.013. Epub 2008 Nov 14. J Chromatogr B Analyt Technol Biomed Life Sci. 2009. PMID: 19041286 Review.
Whilst this approach is suitable for the development of single biomarkers, with the current drive towards larger panels of multiplexed biomarkers, the process becomes inefficient and costly. Consequently, the emphasis is now shifting towards performing full bioma …
Whilst this approach is suitable for the development of single biomarkers, with the current drive towards larger panels of multiplexe …
Leveraging biomarker platforms and systems biology for rehabilomics and biologics effectiveness research.
Kobeissy FH, Guingab-Cagmat JD, Razafsha M, O'Steen L, Zhang Z, Hayes RL, Chiu WT, Wang KK. Kobeissy FH, et al. PM R. 2011 Jun;3(6 Suppl 1):S139-47. doi: 10.1016/j.pmrj.2011.02.012. PM R. 2011. PMID: 21703572 Review.
Among the major obstacles that contribute to this type of misconception is the absence of brain injury-specific diagnostic biomarker(s) that can indicate and monitor the long-term health status of patients with TBI after use of conventional therapeutics and a rehabi …
Among the major obstacles that contribute to this type of misconception is the absence of brain injury-specific diagnostic biomarker( …
Stability-based biomarker selection.
Wehrens R, Franceschi P, Vrhovsek U, Mattivi F. Wehrens R, et al. Anal Chim Acta. 2011 Oct 31;705(1-2):15-23. doi: 10.1016/j.aca.2011.01.039. Epub 2011 Feb 1. Anal Chim Acta. 2011. PMID: 21962342
Biomarker identification, i.e., finding those variables that indicate true differences between two or more populations, is an ever more important topic in the omics sciences. In most cases, the number of variables far exceeds the number of samples, making biomarker …
Biomarker identification, i.e., finding those variables that indicate true differences between two or more populations, is an ever mo …
Accelerating protein biomarker discovery and translation from proteomics research for clinical utility.
Chen J, Zheng N. Chen J, et al. Bioanalysis. 2020 Oct;12(20):1469-1481. doi: 10.4155/bio-2020-0198. Epub 2020 Oct 2. Bioanalysis. 2020. PMID: 33006485
Discovery proteomics research has made significant progress in the past several years; however, the number of protein biomarkers deployed in clinical practice remains rather limited. There are several scientific and procedural gaps between discovery proteomics research and …
Discovery proteomics research has made significant progress in the past several years; however, the number of protein biomarkers depl …
Sex consideration in diet-biomarker-related indices: a systematic review.
Song S, Kim S, Lee JE. Song S, et al. Public Health Nutr. 2018 Oct;21(14):2617-2629. doi: 10.1017/S1368980018001490. Epub 2018 Jun 18. Public Health Nutr. 2018. PMID: 29911516 Free PMC article.
OBJECTIVE: An index of biomarkers derived from dietary factors (diet-biomarker-related index) identifies foods and nutrients that encompass physiological potentials and provides scientific evidence for dietary patterns that increase the risk of disease associated wi …
OBJECTIVE: An index of biomarkers derived from dietary factors (diet-biomarker-related index) identifies foods and nutrients t …
Analytical strategies in lipidomics and applications in disease biomarker discovery.
Hu C, van der Heijden R, Wang M, van der Greef J, Hankemeier T, Xu G. Hu C, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 15;877(26):2836-46. doi: 10.1016/j.jchromb.2009.01.038. Epub 2009 Feb 5. J Chromatogr B Analyt Technol Biomed Life Sci. 2009. PMID: 19233743 Review.
Investigating lipid biochemistry using a lipidomics approach will not only provide insights into the specific roles of lipid molecular species in health and disease, but will also assist in identifying potential biomarkers for establishing preventive or therapeutic approac …
Investigating lipid biochemistry using a lipidomics approach will not only provide insights into the specific roles of lipid molecular speci …
Diagnostic biomarker kinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance: the case of S100B.
Murcko R, Marchi N, Bailey D, Janigro D. Murcko R, et al. Fluids Barriers CNS. 2022 May 11;19(1):32. doi: 10.1186/s12987-022-00329-9. Fluids Barriers CNS. 2022. PMID: 35546671 Free PMC article.
We developed an open-source pharmacokinetic computer model that allows investigations of biomarker's movement across the body, the sources of biomarker's release, and its elimination. ...Three key variables control biomarker levels in blood or s …
We developed an open-source pharmacokinetic computer model that allows investigations of biomarker's movement across the body, …
Biomarker discovery and related topics.
Guttman A. Guttman A. Electrophoresis. 2011 Aug;32(15):1915. doi: 10.1002/elps.201190060. Electrophoresis. 2011. PMID: 21792985 No abstract available.
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances.
Feng X, Wang S, Liu Q, Li H, Liu J, Xu C, Yang W, Shu Y, Zheng W, Yu B, Qi M, Zhou W, Zhou F. Feng X, et al. J Vis Exp. 2018 Oct 11;(140):57738. doi: 10.3791/57738. J Vis Exp. 2018. PMID: 30371672 Free PMC article.
Biomarker detection is one of the more important biomedical questions for high-throughput 'omics' researchers, and almost all existing biomarker detection algorithms generate one biomarker subset with the optimized performance measurement for a given dataset. …
Biomarker detection is one of the more important biomedical questions for high-throughput 'omics' researchers, and almost all existin …
Classification of Companion Diagnostics: A New Framework for Biomarker-Driven Patient Selection.
Huber C, Friede T, Stingl J, Benda N. Huber C, et al. Ther Innov Regul Sci. 2022 Mar;56(2):244-254. doi: 10.1007/s43441-021-00352-2. Epub 2021 Nov 28. Ther Innov Regul Sci. 2022. PMID: 34841493 Free PMC article.
RESULTS: A classification of five biomarker-drug categories is proposed related to increasing evidence on the biomarker's predictive value in relation to a specific drug. We classified biomarkers into five ascending categories with increasing evidence …
RESULTS: A classification of five biomarker-drug categories is proposed related to increasing evidence on the biomarker's …
Latest advances in biomarker discovery and development.
Tracy M. Tracy M. Drugs Today (Barc). 2012 Nov;48(11):735-9. doi: 10.1358/dot.2012.48.11.1828779. Drugs Today (Barc). 2012. PMID: 23170309 Review.
Oxford Global's 7th Annual Biomarkers Congress, held February 21-22, 2012, in Manchester (UK), gathered together approximately 300 delegates and speakers with a specific interest in biomarkers and their application in the field of drug discovery and development, as …
Oxford Global's 7th Annual Biomarkers Congress, held February 21-22, 2012, in Manchester (UK), gathered together approximately 300 de …
Role of the S100B serum biomarker in the treatment of children suffering from mild traumatic brain injury.
Filippidis AS, Papadopoulos DC, Kapsalaki EZ, Fountas KN. Filippidis AS, et al. Neurosurg Focus. 2010 Nov;29(5):E2. doi: 10.3171/2010.8.FOCUS10185. Neurosurg Focus. 2010. PMID: 21039136 Review.
OBJECT: The aim of this study was to provide a systematic update of the current literature regarding the clinical role of the S100B serum biomarker in the initial evaluation of children who have sustained a mild traumatic brain injury (TBI). ...CONCLUSIONS: The vulnerabili …
OBJECT: The aim of this study was to provide a systematic update of the current literature regarding the clinical role of the S100B serum …
The application of mass spectrometry to proteomics and metabolomics in biomarker discovery and drug development.
Mikami T, Aoki M, Kimura T. Mikami T, et al. Curr Mol Pharmacol. 2012 Jun;5(2):301-16. doi: 10.2174/1874467211205020301. Curr Mol Pharmacol. 2012. PMID: 22122469 Review.
Omics technologies play an important role in biomarker discovery as well as in other stages of the drug discovery and development (e.g. target discovery, mechanism of action or predicting toxicity). ...In addition, we discuss the possible impact of biomarker researc …
Omics technologies play an important role in biomarker discovery as well as in other stages of the drug discovery and development (e. …
Imaging mass spectrometry in biomarker discovery and validation.
Schwamborn K. Schwamborn K. J Proteomics. 2012 Aug 30;75(16):4990-4998. doi: 10.1016/j.jprot.2012.06.015. Epub 2012 Jun 27. J Proteomics. 2012. PMID: 22749859 Review.
Biomarker discovery and validation involves the consideration of many issues and challenges in order to be effectively used for translation from bench to bedside. ...
Biomarker discovery and validation involves the consideration of many issues and challenges in order to be effectively used for trans …
Biomarker discovery and related topics.
Guttman A. Guttman A. Electrophoresis. 2009 Apr;30(7):1095. doi: 10.1002/elps.200990036. Electrophoresis. 2009. PMID: 19373802 No abstract available.
The future of protein biomarker research in type 2 diabetes mellitus.
Tans R, Verschuren L, Wessels HJCT, Bakker SJL, Tack CJ, Gloerich J, van Gool AJ. Tans R, et al. Expert Rev Proteomics. 2019 Feb;16(2):105-115. doi: 10.1080/14789450.2018.1551134. Epub 2018 Nov 27. Expert Rev Proteomics. 2019. PMID: 30468403
Areas covered: This review describes the complex onset of T2DM, the contribution of obesity and adipose tissue inflammation to the T2DM disease mechanism, and the output of current biomarker strategies. A new biomarker approach is described that combines published a …
Areas covered: This review describes the complex onset of T2DM, the contribution of obesity and adipose tissue inflammation to the T2DM dise …
Chemo-enzymatic synthesis of the ALG1-CDG biomarker and evaluation of its immunogenicity.
Jia JX, Kalisa NY, Lu TT, Zhou Z, Gao XD, Wang N. Jia JX, et al. Bioorg Med Chem Lett. 2020 Dec 15;30(24):127614. doi: 10.1016/j.bmcl.2020.127614. Epub 2020 Oct 17. Bioorg Med Chem Lett. 2020. PMID: 33080352
., Neu5Ac-alpha2, 6-Gal-beta1, 4-GlcNAc-beta1, 4-GlcNAc, was recently reported as the biomarker of ALG1-CDG, the disease caused by ALG1 deficiency. To develop a novel diagnostic method for ALG1-CDG, chemo-enzymatic synthesis of the tetrasaccharide biomarker linked t …
., Neu5Ac-alpha2, 6-Gal-beta1, 4-GlcNAc-beta1, 4-GlcNAc, was recently reported as the biomarker of ALG1-CDG, the disease caused by AL …
NMR-based metabolomics coupled with pattern recognition methods in biomarker discovery and disease diagnosis.
Zhang AH, Sun H, Qiu S, Wang XJ. Zhang AH, et al. Magn Reson Chem. 2013 Sep;51(9):549-56. doi: 10.1002/mrc.3985. Epub 2013 Jul 4. Magn Reson Chem. 2013. PMID: 23828598 Review.
Molecular biomarkers could detect biochemical changes associated with disease processes. ...In this review, we will present several special examples of a successful application of NMR for biomarker discovery, implications for disease diagnosis, prognosis, and therap …
Molecular biomarkers could detect biochemical changes associated with disease processes. ...In this review, we will present several s …
[The designs of exploratory biomarker study].
Gosho M, Nagashima K, Sato Y. Gosho M, et al. Nihon Rinsho. 2012 May;70(5):874-9. Nihon Rinsho. 2012. PMID: 22620016 Review. Japanese.
First, we define the term "biomarker" and illustrate the difference between prognostic and predictive markers. Second, in exploratory clinical studies, we focus on issues related to study design for screening and evaluating biomarkers. Finally, we review the design …
First, we define the term "biomarker" and illustrate the difference between prognostic and predictive markers. Second, in exploratory …
Dynamic network biomarker to determine the critical point of breast cancer stage progression.
Jiang F, Yang L, Jiao X. Jiang F, et al. Breast Cancer. 2023 May;30(3):453-465. doi: 10.1007/s12282-023-01438-5. Epub 2023 Feb 18. Breast Cancer. 2023. PMID: 36807044
BACKGROUND: The discovery of early warning signs and biomarkers in patients with early breast cancer is crucial for the prevention and treatment of breast cancer. ...CONCLUSION: The discovery of DNBs and the key gene GPRIN1 can provide potential biomarkers and thera …
BACKGROUND: The discovery of early warning signs and biomarkers in patients with early breast cancer is crucial for the prevention an …
Proteomics of human cerebrospinal fluid: discovery and verification of biomarker candidates in neurodegenerative diseases using quantitative proteomics.
Kroksveen AC, Opsahl JA, Aye TT, Ulvik RJ, Berven FS. Kroksveen AC, et al. J Proteomics. 2011 Apr 1;74(4):371-88. doi: 10.1016/j.jprot.2010.11.010. Epub 2010 Nov 25. J Proteomics. 2011. PMID: 21111852 Review.
Quantitative proteomics and sophisticated computational software applied to analyze the protein content of CSF has been fronted as an attractive approach to find novel biomarkers for neurological diseases. This review will focus on some of the potential pitfalls in biom …
Quantitative proteomics and sophisticated computational software applied to analyze the protein content of CSF has been fronted as an attrac …
Perspectives of targeted mass spectrometry for protein biomarker verification.
Hüttenhain R, Malmström J, Picotti P, Aebersold R. Hüttenhain R, et al. Curr Opin Chem Biol. 2009 Dec;13(5-6):518-25. doi: 10.1016/j.cbpa.2009.09.014. Epub 2009 Oct 7. Curr Opin Chem Biol. 2009. PMID: 19818677 Free PMC article. Review.
A major challenge in the process of verifying biomarker candidates in blood plasma is the complexity and high dynamic range of proteins. This article reviews the current, targeted proteomic strategies that are capable of quantifying biomarker candidates at concentra …
A major challenge in the process of verifying biomarker candidates in blood plasma is the complexity and high dynamic range of protei …
Circulating tumors cells as biomarkers: progress toward biomarker qualification.
Danila DC, Pantel K, Fleisher M, Scher HI. Danila DC, et al. Cancer J. 2011 Nov-Dec;17(6):438-50. doi: 10.1097/PPO.0b013e31823e69ac. Cancer J. 2011. PMID: 22157288 Free PMC article. Review.
Personalized cancer medicine requires the development of tumor-specific biomarkers to optimize selection of targeted therapies and to better assess response to therapy. ...Rather, multiple assays (tests) are in development for CTC biomarkers. However, before the rol …
Personalized cancer medicine requires the development of tumor-specific biomarkers to optimize selection of targeted therapies and to …
Quantitative mass spectrometry-based techniques for clinical use: biomarker identification and quantification.
Simpson KL, Whetton AD, Dive C. Simpson KL, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 May 1;877(13):1240-9. doi: 10.1016/j.jchromb.2008.11.023. Epub 2008 Nov 18. J Chromatogr B Analyt Technol Biomed Life Sci. 2009. PMID: 19058768 Free PMC article. Review.
However, there are challenges to be overcome for the identification and validation of robust biomarkers. Bio-fluids such as plasma and serum are a rich source of protein, many of which may reflect disease status, and due to the ease of sampling and handling, novel blood bo …
However, there are challenges to be overcome for the identification and validation of robust biomarkers. Bio-fluids such as plasma an …
Recent advances in microfluidic sample preparation and separation techniques for molecular biomarker analysis: A critical review.
Sonker M, Sahore V, Woolley AT. Sonker M, et al. Anal Chim Acta. 2017 Sep 15;986:1-11. doi: 10.1016/j.aca.2017.07.043. Epub 2017 Jul 24. Anal Chim Acta. 2017. PMID: 28870312 Free PMC article. Review.
Researchers have recently reported various microfluidic platforms for biomarker analysis applications. Sample preparation processes like purification, preconcentration and labeling have been characterized on-chip. Additionally, improvements in microfluidic separation techn …
Researchers have recently reported various microfluidic platforms for biomarker analysis applications. Sample preparation processes l …
Capillary electrophoresis interfaced with a mass spectrometer (CE-MS): technical considerations and applicability for biomarker studies in animals.
Albalat A, Husi H, Siwy J, Nally JE, McLauglin M, Eckersall PD, Mullen W. Albalat A, et al. Curr Protein Pept Sci. 2014 Feb;15(1):23-35. doi: 10.2174/1389203715666140221123920. Curr Protein Pept Sci. 2014. PMID: 24555889 Review.
The aim of this review is to present CE-MS as a proteomic analytical platform for biomarker research that could be used in farm animal and veterinary studies. This is a MS-analytical platform that has been widely used for biomarker research in the biomedical field b …
The aim of this review is to present CE-MS as a proteomic analytical platform for biomarker research that could be used in farm anima …
Unlocking the molecular archive: the emerging use of formalin-fixed paraffin-embedded tissue for biomarker research in urological cancer.
Gnanapragasam VJ. Gnanapragasam VJ. BJU Int. 2010 Jan;105(2):274-8. doi: 10.1111/j.1464-410X.2009.08665.x. Epub 2009 Jun 10. BJU Int. 2010. PMID: 19519763 Review.
The disadvantage of this process is that the sampled tissue might not be entirely representative of the tumour and there is a lack of adequate numbers and follow-up to make clear conclusions as to a biomarker's prognostic potential. Formalin fixation and paraffin em …
The disadvantage of this process is that the sampled tissue might not be entirely representative of the tumour and there is a lack of adequa …
Alpha-synuclein in peripheral tissues and body fluids as a biomarker for Parkinson's disease - a systematic review.
Malek N, Swallow D, Grosset KA, Anichtchik O, Spillantini M, Grosset DG. Malek N, et al. Acta Neurol Scand. 2014 Aug;130(2):59-72. doi: 10.1111/ane.12247. Epub 2014 Apr 5. Acta Neurol Scand. 2014. PMID: 24702516 Review.
The aim of this study was to conduct a systematic review of available evidence to determine the utility of alpha-synuclein as a peripheral biomarker of PD. We searched PubMed (1948 to 26 May 2013), Embase (1974 to 26 May 2013), the Cochrane Library (up to 26 May 2013), LIL …
The aim of this study was to conduct a systematic review of available evidence to determine the utility of alpha-synuclein as a peripheral …
Recent advances in capillary electrophoresis for biomarker discovery.
Bakry R, Huck CW, Najam-ul-Haq M, Rainer M, Bonn GK. Bakry R, et al. J Sep Sci. 2007 Feb;30(2):192-201. doi: 10.1002/jssc.200600323. J Sep Sci. 2007. PMID: 17390613 Review.
The use of non-invasive methods for detecting biomarkers opens a new era in patient care, since clinical investigators have long been searching for accurate and reproducible measurements of putative biomarkers. ...This review will focus on recent applications of CE …
The use of non-invasive methods for detecting biomarkers opens a new era in patient care, since clinical investigators have long been …
Proteomics in transplantation.
Kienzl-Wagner K, Brandacher G. Kienzl-Wagner K, et al. Adv Clin Chem. 2014;67:215-44. doi: 10.1016/bs.acc.2014.09.004. Epub 2014 Nov 14. Adv Clin Chem. 2014. PMID: 25735863 Review.
Proteomics and biochemical profiling have emerged as exciting and powerful tools in clinical biomarker research. In the field of transplantation, proteomics aims not only at developing noninvasive means for immune monitoring but also to gain mechanistic insights into the p …
Proteomics and biochemical profiling have emerged as exciting and powerful tools in clinical biomarker research. In the field of tran …
Identifying Biomarkers of Spinal Muscular Atrophy for Further Development.
Glascock J, Darras BT, Crawford TO, Sumner CJ, Kolb SJ, DiDonato C, Elsheikh B, Howell K, Farwell W, Valente M, Petrillo M, Tingey J, Jarecki J. Glascock J, et al. J Neuromuscul Dis. 2023;10(5):937-954. doi: 10.3233/JND-230054. J Neuromuscul Dis. 2023. PMID: 37458045 Free PMC article.
The wide range of disease severities, variable rates of decline, and heterogenous clinical responses to approved disease-modifying treatment remain poorly understood and limit the ability to optimize treatment for patients. Validation of a reliable biomarker(s) with …
The wide range of disease severities, variable rates of decline, and heterogenous clinical responses to approved disease-modifying treatment …
Assay Development and Measurement of the Aging Biomarker Humanin.
Miller B, Wan J. Miller B, et al. Methods Mol Biol. 2020;2144:201-209. doi: 10.1007/978-1-0716-0592-9_18. Methods Mol Biol. 2020. PMID: 32410037
Biomarkers that reflect aging could be used to target age-related diseases with precision and monitor treatment efficacy. One such biomarker is humanin, a 24-amino acid mitochondrial-derived peptide encoded within the mitochondrial 16S rRNA gene. ...
Biomarkers that reflect aging could be used to target age-related diseases with precision and monitor treatment efficacy. One such …
Role of proteomics in biomarker discovery and psychiatric disorders: current status, potentials, limitations and future challenges.
Patel S. Patel S. Expert Rev Proteomics. 2012 Jun;9(3):249-65. doi: 10.1586/epr.12.25. Expert Rev Proteomics. 2012. PMID: 22809205 Review.
Despite tremendous research efforts to dissect the neurobiological basis of psychiatric disorders, the diagnosis and evaluation for such diseases is still poor. Biomarker discovery in psychiatry research has been accelerated by proteomic technologies, accepting the challen …
Despite tremendous research efforts to dissect the neurobiological basis of psychiatric disorders, the diagnosis and evaluation for such dis …
Isotopologue Multipoint Calibration for Proteomics Biomarker Quantification in Clinical Practice.
Chiva C, Pastor O, Trilla-Fuertes L, Gámez-Pozo A, Fresno Vara JÁ, Sabidó E. Chiva C, et al. Anal Chem. 2019 Apr 16;91(8):4934-4938. doi: 10.1021/acs.analchem.8b05802. Epub 2019 Mar 25. Anal Chem. 2019. PMID: 30882204
Targeted proteomics has become the method of choice for biomarker validation in human biopsies due to its high sensitivity, reproducibility, accuracy, and precision. ...Our work illustrates how an improvement of mass spectrometry methods for biomarker quantification …
Targeted proteomics has become the method of choice for biomarker validation in human biopsies due to its high sensitivity, reproduci …
Microbial signature lipid biomarker analysis - an approach that is still preferred, even amid various method modifications.
Willers C, Jansen van Rensburg PJ, Claassens S. Willers C, et al. J Appl Microbiol. 2015 Jun;118(6):1251-63. doi: 10.1111/jam.12798. Epub 2015 Apr 8. J Appl Microbiol. 2015. PMID: 25765073 Free article. Review.
Accordingly, the preferential utilization of signature lipid biomarker analysis in current research is considered. It is clear from recent literature that this technique stays relevant - mainly for the variety of microbial properties that can be determined in a single anal …
Accordingly, the preferential utilization of signature lipid biomarker analysis in current research is considered. It is clear from r …
Biomarker context-of-use: how organizational design can impact the implementation of the appropriate biomarker assay strategy.
Cowan KJ, Golob M, Goodman J, Laurén A, Andersen L, Decker P, Dejager L, Fjording MS, Groenen P, Jasnowski R, Justies N, Kimberg M, Kunz U, Lawrence J, Richter M, Sordé L, Trigt RV, Vermet L, Vitaliti A, Wright M, Timmerman P. Cowan KJ, et al. Bioanalysis. 2022 Jul;14(13):911-917. doi: 10.4155/bio-2022-0143. Epub 2022 Jul 29. Bioanalysis. 2022. PMID: 35904153 Free article.
Since 2011, the European Bioanalysis Forum has been discussing the topic of context-of-use for biomarker assays, in support of a cross-industry implementation of its principles. ...In addition to scientific recommendations, the European Bioanalysis Forum has addressed thes …
Since 2011, the European Bioanalysis Forum has been discussing the topic of context-of-use for biomarker assays, in support of a cros …
Proteomics as a tool for clinically relevant biomarker discovery and validation.
Duncan MW, Hunsucker SW. Duncan MW, et al. Exp Biol Med (Maywood). 2005 Dec;230(11):808-17. doi: 10.1177/153537020523001105. Exp Biol Med (Maywood). 2005. PMID: 16339745 Review.
The excitement associated with clinical applications of proteomics was initially focused on its potential to serve as a vehicle for both biomarker discovery and drug discovery and routine clinical sample analysis. ...While we see an important place for mass spectrometry in …
The excitement associated with clinical applications of proteomics was initially focused on its potential to serve as a vehicle for both …
Biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review.
Maksoud R, Magawa C, Eaton-Fitch N, Thapaliya K, Marshall-Gradisnik S. Maksoud R, et al. BMC Med. 2023 May 24;21(1):189. doi: 10.1186/s12916-023-02893-9. BMC Med. 2023. PMID: 37226227 Free PMC article.
While there are some studies that report potential biomarkers for ME/CFS, their efficacy has not been validated. The aim of this systematic review is to collate and appraise literature pertaining to a potential biomarker(s) which may effectively differentiate …
While there are some studies that report potential biomarkers for ME/CFS, their efficacy has not been validated. The aim of this syst …
[Progress in the biomarker discovery for drug-induced liver injury].
He LY, Guo YX, Li C, Deng Y, Zhang QZ, Peng WX. He LY, et al. Yao Xue Xue Bao. 2015 Aug;50(8):959-65. Yao Xue Xue Bao. 2015. PMID: 26668994 Review. Chinese.
In order to reduce the occurrence of DILI, researchers have attempted to discover potential biomarkers with higher specificity and sensitivity from blood and urine in recent years. This article aims to review recent advances in biomarkers of DILI....
In order to reduce the occurrence of DILI, researchers have attempted to discover potential biomarkers with higher specificity and se …
Soluble neprilysin: A versatile biomarker for heart failure, cardiovascular diseases and diabetic complications-A systematic review.
Ramanathan K, Padmanabhan G. Ramanathan K, et al. Indian Heart J. 2020 Jan-Feb;72(1):14-19. doi: 10.1016/j.ihj.2020.01.006. Epub 2020 Feb 4. Indian Heart J. 2020. PMID: 32423555 Free PMC article.
The potential role of soluble neprilysin (sNEP) as a biomarker has been poorly documented. Hence, the present systematic review emphasizes to explore sNEP as an emerging biomarker for heart failure (HF), cardiovascular diseases, diabetic kidney diseases, and so on. …
The potential role of soluble neprilysin (sNEP) as a biomarker has been poorly documented. Hence, the present systematic review empha …
Identifying dynamical persistent biomarker structures for rare events using modern integrative machine learning approach.
Dutta S, Box AC, Li Y, Sardiu ME. Dutta S, et al. Proteomics. 2023 Nov;23(21-22):e2200290. doi: 10.1002/pmic.202200290. Epub 2023 Mar 10. Proteomics. 2023. PMID: 36852539
In addition, cytometry data frequently exhibit diverse patterns across biomarkers and suffer from substantial class imbalances which can further complicate the problem. ...Given that our approach integrates superior performing ML models across different normalization techn …
In addition, cytometry data frequently exhibit diverse patterns across biomarkers and suffer from substantial class imbalances which …
New horizons in biomarker research.
Von Herrath M, Jarjour WN. Von Herrath M, et al. Clin Immunol. 2015 Nov;161(1):1. doi: 10.1016/j.clim.2015.09.005. Epub 2015 Sep 15. Clin Immunol. 2015. PMID: 26383133 No abstract available.
Banking of clinical samples for proteomic biomarker studies: a consideration of logistical issues with a focus on pre-analytical variation.
Jackson DH, Banks RE. Jackson DH, et al. Proteomics Clin Appl. 2010 Mar;4(3):250-70. doi: 10.1002/prca.200900220. Epub 2010 Jan 7. Proteomics Clin Appl. 2010. PMID: 21137047 Review.
Biobanks with their collections of clinical samples and data are essential resources for the success of clinical proteomics in delivering and validating candidate biomarkers. Samples must be banked in a manner that allows maximum subsequent compatibility with analytical te …
Biobanks with their collections of clinical samples and data are essential resources for the success of clinical proteomics in delivering an …
Advances in mechanical biomarkers.
Eroles M, Rico F. Eroles M, et al. J Mol Recognit. 2023 Aug;36(8):e3022. doi: 10.1002/jmr.3022. Epub 2023 Jun 8. J Mol Recognit. 2023. PMID: 37092676 Review.
Mechanical biomarkers distinguish health conditions through quantitative mechanical measurements. ...Mechanical changes in cells and tissues may be detected before other markers, such as protein expression, providing an important advantage as biomarkers. In the pres …
Mechanical biomarkers distinguish health conditions through quantitative mechanical measurements. ...Mechanical changes in cells and …
Is there a maternal blood biomarker that can predict spontaneous preterm birth prior to labour onset? A systematic review.
Hornaday KK, Wood EM, Slater DM. Hornaday KK, et al. PLoS One. 2022 Apr 4;17(4):e0265853. doi: 10.1371/journal.pone.0265853. eCollection 2022. PLoS One. 2022. PMID: 35377904 Free PMC article.
INTRODUCTION: The ability to predict spontaneous preterm birth (sPTB) prior to labour onset is a challenge, and it is currently unclear which biomarker(s), may be potentially predictive of sPTB, and whether their predictive power has any utility. ...Immune and signa …
INTRODUCTION: The ability to predict spontaneous preterm birth (sPTB) prior to labour onset is a challenge, and it is currently unclear whic …
Calibrator material selection: a key criteria during biomarker assay method development.
Thankamony SP, Liu R, Peterson JE, Santockyte R, Olah T, Zhang Y. Thankamony SP, et al. Bioanalysis. 2021 May;13(10):787-796. doi: 10.4155/bio-2020-0208. Epub 2021 May 7. Bioanalysis. 2021. PMID: 33960820
Biomarker assay method development is a multistep rigorous process and calibrant material selection is integral to ensuring the quality of such assays. ...We also provide additional perspectives for selection and characterization of calibrant proteins in the setting of an …
Biomarker assay method development is a multistep rigorous process and calibrant material selection is integral to ensuring the quali …
[The concept and history of biomarker].
Nonaka R, Nishimura J, Mori M. Nonaka R, et al. Nihon Rinsho. 2012 May;70(5):737-42. Nihon Rinsho. 2012. PMID: 22619994 Review. Japanese.
Biomarker is a characteristic objectively measured and an indicator of biological process. ...Here, we summarize the concept and history of biomarker....
Biomarker is a characteristic objectively measured and an indicator of biological process. ...Here, we summarize the concept and hist …
Cancer Biomarkers for Integrative Oncology.
Ganguly A, Frank D, Kumar N, Cheng YC, Chu E. Ganguly A, et al. Curr Oncol Rep. 2019 Mar 5;21(4):32. doi: 10.1007/s11912-019-0782-6. Curr Oncol Rep. 2019. PMID: 30834992 Review.
Herein, we review the status of cancer biomarkers in CAM research and treatment to stimulate further research in this area. RECENT FINDINGS: Studies on promising anti-cancer natural products, such as PHY906, honokiol, bryostatin-1, and sulforaphane have demonstrated the ex …
Herein, we review the status of cancer biomarkers in CAM research and treatment to stimulate further research in this area. RECENT FI …
Serum HSP90-Alpha and Oral Squamous Cell Carcinoma: A Prospective Biomarker.
Usman M, Ilyas A, Syed B, Hashim Z, Ahmed A, Zarina S. Usman M, et al. Protein Pept Lett. 2021;28(10):1157-1163. doi: 10.2174/0929866528666210616112539. Protein Pept Lett. 2021. PMID: 34137356
AIM: This study aims to perform differential protein expression analysis of serum samples from Oral Squamous Cell Carcinoma (OSCC) patients and healthy controls in search of potential diagnostic and/or prognostic biomarker(s). OBJECTIVE: OSCC is usually diagnosed la …
AIM: This study aims to perform differential protein expression analysis of serum samples from Oral Squamous Cell Carcinoma (OSCC) patients …
The comparative and added prognostic value of biomarkers to the Revised Cardiac Risk Index for preoperative prediction of major adverse cardiac events and all-cause mortality in patients who undergo noncardiac surgery.
Vernooij LM, van Klei WA, Moons KG, Takada T, van Waes J, Damen JA. Vernooij LM, et al. Cochrane Database Syst Rev. 2021 Dec 21;12(12):CD013139. doi: 10.1002/14651858.CD013139.pub2. Cochrane Database Syst Rev. 2021. PMID: 34931303 Free PMC article. Review.
SELECTION CRITERIA: We included studies among adults who underwent noncardiac surgery, reporting on (external) validation of the RCRI and: - the addition of biomarker(s) to the RCRI; or - the comparison of the predictive accuracy of biomarker(s) to the …
SELECTION CRITERIA: We included studies among adults who underwent noncardiac surgery, reporting on (external) validation of the RCRI and: - …
Scale-Invariant Biomarker Discovery in Urine and Plasma Metabolite Fingerprints.
Zacharias HU, Rehberg T, Mehrl S, Richtmann D, Wettig T, Oefner PJ, Spang R, Gronwald W, Altenbuchinger M. Zacharias HU, et al. J Proteome Res. 2017 Oct 6;16(10):3596-3605. doi: 10.1021/acs.jproteome.7b00325. Epub 2017 Sep 7. J Proteome Res. 2017. PMID: 28825821
Such scaling of the data, however, may affect the selection of biomarkers and the biological interpretation of results in unforeseen ways. ...To overcome this problem for metabolite signatures and to establish a scale-invariant biomarker discovery algorithm, we exte …
Such scaling of the data, however, may affect the selection of biomarkers and the biological interpretation of results in unforeseen …
Monitoring Neurodegeneration in Glaucoma: Therapeutic Implications.
Ban N, Siegfried CJ, Apte RS. Ban N, et al. Trends Mol Med. 2018 Jan;24(1):7-17. doi: 10.1016/j.molmed.2017.11.004. Epub 2017 Dec 7. Trends Mol Med. 2018. PMID: 29233479 Free PMC article. Review.
Therefore, there is a clear need to identify quantifiable molecular biomarkers of glaucomatous neurodegeneration. As such, in our opinion, molecular biomarker(s) that specifically reflect stress or death of RGCs, and which correlate with disease severity, pro …
Therefore, there is a clear need to identify quantifiable molecular biomarkers of glaucomatous neurodegeneration. As such, in our opi …
Pharmacogenomic biomarker information on drug labels of the Spanish Agency of Medicines and Sanitary products: evaluation and comparison with other regulatory agencies.
Estévez-Paredes M, Mata-Martín MC, de Andrés F, LLerena A. Estévez-Paredes M, et al. Pharmacogenomics J. 2024 Jan 17;24(1):2. doi: 10.1038/s41397-023-00321-y. Pharmacogenomics J. 2024. PMID: 38233388
This work aimed to analyse the pharmacogenetic information in the Spanish Drug Regulatory Agency (AEMPS) Summary of Products Characteristics (SmPC), evaluating the presence of pharmacogenetic biomarkers, as well as the associated recommendations. A total of 55.4% of the 18 …
This work aimed to analyse the pharmacogenetic information in the Spanish Drug Regulatory Agency (AEMPS) Summary of Products Characteristics …
A review of lysosomal membrane stability measured by neutral red retention: is it a workable earthworm biomarker?
Svendsen C, Spurgeon DJ, Hankard PK, Weeks JM. Svendsen C, et al. Ecotoxicol Environ Saf. 2004 Jan;57(1):20-9. doi: 10.1016/j.ecoenv.2003.08.009. Ecotoxicol Environ Saf. 2004. PMID: 14659363 Review.
This paper redresses this imbalance by drawing together data from studies that have used the earthworm lysosomal membrane stability response (measured using the neutral red retention assay). This review first gives a short history of the biomarker's development. Sec …
This paper redresses this imbalance by drawing together data from studies that have used the earthworm lysosomal membrane stability response …
TPD: a web tool for tipping-point detection based on dynamic network biomarker.
Chen P, Zhong J, Yang K, Zhang X, Chen Y, Liu R. Chen P, et al. Brief Bioinform. 2022 Sep 20;23(5):bbac399. doi: 10.1093/bib/bbac399. Brief Bioinform. 2022. PMID: 36088546
We present the tipping point detector (TPD), a web tool for the detection of the tipping point during the dynamic process of biological systems, and further its leading molecules or network, based on the input high-dimensional time series or stage course data. With the solid theo …
We present the tipping point detector (TPD), a web tool for the detection of the tipping point during the dynamic process of biological syst …
[Cyclic GMP as a biomarker for cardiovascular disease and cancer].
Ulvestad L, Sager G. Ulvestad L, et al. Tidsskr Nor Laegeforen. 2005 Jan 6;125(1):27-8. Tidsskr Nor Laegeforen. 2005. PMID: 15643459 Free article. Review. Norwegian.
MATERIALS AND METHODS: This paper is based on studies of cGMP as a biomarker. RESULTS AND INTERPRETATION: It is well documented that cGMP levels are elevated in plasma in patients with heart failure and various leukaemias and in urine from patients with gynaecological canc …
MATERIALS AND METHODS: This paper is based on studies of cGMP as a biomarker. RESULTS AND INTERPRETATION: It is well documented that …
Statistical Considerations in the Evaluation of Continuous Biomarkers.
Polley MC, Dignam JJ. Polley MC, et al. J Nucl Med. 2021 May 10;62(5):605-611. doi: 10.2967/jnumed.120.251520. Epub 2021 Feb 12. J Nucl Med. 2021. PMID: 33579807 Free PMC article. Review.
One particular challenge that may have hindered the adoption of biomarkers into practice is the lack of reproducible biomarker cut points. ...Second, we review the popular "minimal-P-value" approach for cut point identification and show that this method results in h …
One particular challenge that may have hindered the adoption of biomarkers into practice is the lack of reproducible biomarker …
Biomarkers in Pharmaceutical Research.
Zhao X, Modur V, Carayannopoulos LN, Laterza OF. Zhao X, et al. Clin Chem. 2015 Nov;61(11):1343-53. doi: 10.1373/clinchem.2014.231712. Epub 2015 Sep 25. Clin Chem. 2015. PMID: 26408531 Review.
It also covers the use of biomarkers as surrogate end points and patient selection/companion diagnostics and provides insights into clinical biomarker discovery and biomarker development/validation with regulatory implications. To survey biomarkers use …
It also covers the use of biomarkers as surrogate end points and patient selection/companion diagnostics and provides insights into c …
How should we be using biomarkers in trials of disease modification in Parkinson's disease?
Vijiaratnam N, Foltynie T. Vijiaratnam N, et al. Brain. 2023 Dec 1;146(12):4845-4869. doi: 10.1093/brain/awad265. Brain. 2023. PMID: 37536279 Free PMC article.
The choice of which biomarker(s) to use in the context of disease modifying clinical trials will depend on the intervention, the stage (at risk, premotor, motor, complex) of the population recruited and the aims of the trial. ...However, correlation with clinical pr …
The choice of which biomarker(s) to use in the context of disease modifying clinical trials will depend on the intervention, t …
Integrated biomarker responses: a further improvement of IBR and IBRv2 indexes to preserve data variability in statistical analyses.
Mattos JJ, Siebert MN, Bainy ACD. Mattos JJ, et al. Environ Sci Pollut Res Int. 2024 Jan;31(1):871-881. doi: 10.1007/s11356-023-31255-4. Epub 2023 Nov 30. Environ Sci Pollut Res Int. 2024. PMID: 38032530
In biomonitoring and laboratory studies, it is typical to measure a battery of molecular, biochemical, and cytogenetic biomarkers to evaluate the effects of xenobiotics in biota. However, summarizing the results of several biomarkers to inform laypersons and environ …
In biomonitoring and laboratory studies, it is typical to measure a battery of molecular, biochemical, and cytogenetic biomarkers to …
The issues and challenges with cancer biomarkers.
Purkayastha K, Dhar R, Pethusamy K, Srivastava T, Shankar A, Rath GK, Karmakar S. Purkayastha K, et al. J Cancer Res Ther. 2023 Apr;19(Supplement):S20-S35. doi: 10.4103/jcrt.jcrt_384_22. J Cancer Res Ther. 2023. PMID: 37147979 Free article. Review.
The highest percent of all biomarkers explored are in the domain of cancer. Extensive research using various methods/tissues is carried out for identifying biomarkers for early detection, which has been mostly unsuccessful. ...Many biomarkers are presently un …
The highest percent of all biomarkers explored are in the domain of cancer. Extensive research using various methods/tissues is carri …
Buccal Mucosa Biomarkers in Alzheimer's Disease.
Avramouli A, Vlamos P. Avramouli A, et al. Adv Exp Med Biol. 2020;1195:49-56. doi: 10.1007/978-3-030-32633-3_8. Adv Exp Med Biol. 2020. PMID: 32468458 Review.
Alzheimer's disease (AD) precipitation in the elderly population increases the need for sensitive biomarkers that can be applied to large population screening. Buccal cells can be obtained easily, noninvasively, and contain many proteins related to cerebral processes. Henc …
Alzheimer's disease (AD) precipitation in the elderly population increases the need for sensitive biomarkers that can be applied to l …
Hair Manganese as an Exposure Biomarker among Welders.
Reiss B, Simpson CD, Baker MG, Stover B, Sheppard L, Seixas NS. Reiss B, et al. Ann Occup Hyg. 2016 Mar;60(2):139-49. doi: 10.1093/annhyg/mev064. Epub 2015 Sep 25. Ann Occup Hyg. 2016. PMID: 26409267 Free PMC article.
Common biological markers such as Mn in blood or Mn in urine have not proven to be practical biomarkers even in studies where positive associations were observed. However, hair Mn (MnH) as a biomarker has the advantage over blood and urine that it is less influenced …
Common biological markers such as Mn in blood or Mn in urine have not proven to be practical biomarkers even in studies where positiv …
Protein biomarkers in renal transplantation.
Chakraborty A, Sarwal M. Chakraborty A, et al. Expert Rev Proteomics. 2018 Jan;15(1):41-54. doi: 10.1080/14789450.2018.1396892. Epub 2017 Nov 14. Expert Rev Proteomics. 2018. PMID: 29106314 Review.
Areas covered: A survey of 273 studies in the biomarker detection field which included proteomics relating to renal pathology and normal controls was done. ...It also revealed biomarkers proposed for better detection of these pathologies and the strength (sensitivit …
Areas covered: A survey of 273 studies in the biomarker detection field which included proteomics relating to renal pathology and nor …
Biomarker discovery in biological specimens (plasma, hair, liver and kidney) of diabetic mice based upon metabolite profiling using ultra-performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry.
Tsutsui H, Maeda T, Min JZ, Inagaki S, Higashi T, Kagawa Y, Toyo'oka T. Tsutsui H, et al. Clin Chim Acta. 2011 May 12;412(11-12):861-72. doi: 10.1016/j.cca.2010.12.023. Epub 2010 Dec 24. Clin Chim Acta. 2011. PMID: 21185819
In many cases, diabetes is asymptomatic for a long period and the patient is not aware of the disease. Therefore, the potential biomarker(s), leading to the early detection and/or prevention of diabetes mellitus, are strongly required. ...CONCLUSIONS: N-acetyl-L-leu …
In many cases, diabetes is asymptomatic for a long period and the patient is not aware of the disease. Therefore, the potential biomarker …
Lipidomics biomarker studies: Errors, limitations, and the future.
Wood PL, Cebak JE. Wood PL, et al. Biochem Biophys Res Commun. 2018 Oct 7;504(3):569-575. doi: 10.1016/j.bbrc.2018.03.188. Epub 2018 Mar 27. Biochem Biophys Res Commun. 2018. PMID: 29596837
These issues need to be addressed aggressively as high quality data are essential for the translation of biomarker research to clinical practice....
These issues need to be addressed aggressively as high quality data are essential for the translation of biomarker research to clinic …
Potential Biomarkers for Allergic Conjunctival Diseases.
Roy N, Levanon S, Asbell PA. Roy N, et al. Eye Contact Lens. 2020 Mar;46 Suppl 2(Suppl 2):S109-S121. doi: 10.1097/ICL.0000000000000688. Eye Contact Lens. 2020. PMID: 32097185 Free PMC article. Review.
Although a large body of information exists on the pathophysiology of ACDs, this has not yet lead to the development of clear recommendations and guidelines for the diagnosis of ACDs or development of conclusive and objective diagnostic tools. Identification of objectively measur …
Although a large body of information exists on the pathophysiology of ACDs, this has not yet lead to the development of clear recommendation …
Recent Advances in the Genetics of Hypertension.
Wei LK, Au A, Teh LK, Lye HS. Wei LK, et al. Adv Exp Med Biol. 2017;956:561-581. doi: 10.1007/5584_2016_75. Adv Exp Med Biol. 2017. PMID: 27957710 Review.
Hence, it is essential to gather all the available information on the reported genetic loci and to determine if any biomarker(s) is/are significantly associated with hypertension. Current review concluded the potential biomarkers for hypertension, with regard …
Hence, it is essential to gather all the available information on the reported genetic loci and to determine if any biomarker(s …
Machine Learning Models for the Identification of Prognostic and Predictive Cancer Biomarkers: A Systematic Review.
Al-Tashi Q, Saad MB, Muneer A, Qureshi R, Mirjalili S, Sheshadri A, Le X, Vokes NI, Zhang J, Wu J. Al-Tashi Q, et al. Int J Mol Sci. 2023 Apr 24;24(9):7781. doi: 10.3390/ijms24097781. Int J Mol Sci. 2023. PMID: 37175487 Free PMC article. Review.
The identification of biomarkers plays a crucial role in personalized medicine, both in the clinical and research settings. However, the contrast between predictive and prognostic biomarkers can be challenging due to the overlap between the two. A prognostic biom …
The identification of biomarkers plays a crucial role in personalized medicine, both in the clinical and research settings. However, …
S100B as a biomarker of blood-brain barrier disruption after thoracoabdominal aortic aneurysm repair: a secondary analysis from a prospective cohort study.
Roberts DJ, Hall RI, Wang Y, Julien LC, Wood J, Goralski KB. Roberts DJ, et al. Can J Anaesth. 2021 Dec;68(12):1756-1768. doi: 10.1007/s12630-021-02110-2. Epub 2021 Sep 27. Can J Anaesth. 2021. PMID: 34570352 English.
CONCLUSION: The lack of parallel increases in plasma and CSF S100B following CPB indicates that S100B may not be a reliable biomarker for BBB disruption after thoracoabdominal aortic aneurysm repair employing CPB. ...
CONCLUSION: The lack of parallel increases in plasma and CSF S100B following CPB indicates that S100B may not be a reliable biomarker …
Molecular biomarkers of depression.
Gururajan A, Clarke G, Dinan TG, Cryan JF. Gururajan A, et al. Neurosci Biobehav Rev. 2016 May;64:101-33. doi: 10.1016/j.neubiorev.2016.02.011. Epub 2016 Feb 21. Neurosci Biobehav Rev. 2016. PMID: 26906761 Review.
In this review, we will address several issues pertaining to biomarkers in depression which will be grouped under the headings transcriptomic, proteomic, genomic and telomeric biomarkers. We will review some of the main pitfalls and also address ethical, moral and l …
In this review, we will address several issues pertaining to biomarkers in depression which will be grouped under the headings transc …
Biomarker discovery by CE-MS enables sequence analysis via MS/MS with platform-independent separation.
Zürbig P, Renfrow MB, Schiffer E, Novak J, Walden M, Wittke S, Just I, Pelzing M, Neusüss C, Theodorescu D, Root KE, Ross MM, Mischak H. Zürbig P, et al. Electrophoresis. 2006 Jun;27(11):2111-25. doi: 10.1002/elps.200500827. Electrophoresis. 2006. PMID: 16645980
CE-MS is a successful proteomic platform for the definition of biomarkers in different body fluids. Besides the biomarker defining experimental parameters, CE migration time and molecular weight, especially biomarker's sequence identity is an indispens …
CE-MS is a successful proteomic platform for the definition of biomarkers in different body fluids. Besides the biomarker defi …
Markers of Iron Metabolism and Outcomes in Patients with Heart Failure: A Systematic Review.
Dhaliwal S, Kalogeropoulos AP. Dhaliwal S, et al. Int J Mol Sci. 2023 Mar 15;24(6):5645. doi: 10.3390/ijms24065645. Int J Mol Sci. 2023. PMID: 36982717 Free PMC article. Review.
Results were synthesized based on their respective adverse outcomes and iron metabolism biomarker(s). Initial and updated searches identified 508 unique titles once duplicates were removed. ...Considering the lack of consistency among the iron metabolism biomarke …
Results were synthesized based on their respective adverse outcomes and iron metabolism biomarker(s). Initial and updated sear …
Cancer stem cell biomarkers and related signalling pathways.
Wang Z, Li R, Yang G, Wang Y. Wang Z, et al. J Drug Target. 2024 Dec;32(1):33-44. doi: 10.1080/1061186X.2023.2295222. Epub 2024 Jan 12. J Drug Target. 2024. PMID: 38095181 Review.
Targeted biomarker-based therapies also offer a silver lining for patients with advanced malignancies. This review aims comprehensively to consolidate the latest findings on CSCs biomarkers, targeted agents as well as biomarkers associated signalling pathways …
Targeted biomarker-based therapies also offer a silver lining for patients with advanced malignancies. This review aims comprehensive …
Cardiac biomarkers in cats.
Borgeat K, Connolly DJ, Luis Fuentes V. Borgeat K, et al. J Vet Cardiol. 2015 Dec;17 Suppl 1:S74-86. doi: 10.1016/j.jvc.2015.08.001. J Vet Cardiol. 2015. PMID: 26776596 Review.
Cardiac biomarkers have been used in cats as part of the clinical assessment of heart disease for over a decade. They are widely available to practitioners through commercial reference laboratories. The evidence base for the use of cardiac biomarkers (primarily N-te …
Cardiac biomarkers have been used in cats as part of the clinical assessment of heart disease for over a decade. They are widely avai …
The Antimicrobial Peptide LL-37 as a Predictor Biomarker for Periodontitis with the Presence and Absence of Smoking: A Case-Control Study.
Kzar WA, Abbas RF, Hussein HM. Kzar WA, et al. Biomed Res Int. 2023 Sep 6;2023:5581267. doi: 10.1155/2023/5581267. eCollection 2023. Biomed Res Int. 2023. PMID: 37711877 Free PMC article.
BACKGROUND: A major issue is finding a valid biomarker able to diagnose periodontal disease with the presence and absence of risk factors. ...OBJECTIVES: This investigation examines and contrasts the levels of cathelicidin in the saliva of smokers and nonsmokers of periodo …
BACKGROUND: A major issue is finding a valid biomarker able to diagnose periodontal disease with the presence and absence of risk fac …
Biomarkers of An Autoimmune Skin Disease--Psoriasis.
Jiang S, Hinchliffe TE, Wu T. Jiang S, et al. Genomics Proteomics Bioinformatics. 2015 Aug;13(4):224-33. doi: 10.1016/j.gpb.2015.04.002. Epub 2015 Sep 8. Genomics Proteomics Bioinformatics. 2015. PMID: 26362816 Free PMC article. Review.
Over the last decade, omics-based technologies have been extensively utilized for biomarker discovery. As a result, some promising markers for psoriasis have been identified at the genome, transcriptome, proteome, and metabolome level. ...In this review, we summarize the m …
Over the last decade, omics-based technologies have been extensively utilized for biomarker discovery. As a result, some promising ma …
Which is the urine sample material of choice for metabolomics-driven biomarker studies?
Liu X, Yin P, Shao Y, Wang Z, Wang B, Lehmann R, Xu G. Liu X, et al. Anal Chim Acta. 2020 Apr 8;1105:120-127. doi: 10.1016/j.aca.2020.01.028. Epub 2020 Jan 16. Anal Chim Acta. 2020. PMID: 32138910
Urine-based metabolomics-driven strategies for the discovery of biomarkers are increasingly developed and applied in analytical chemistry. ...Additionally, we describe 47 metabolites in urine, possible hits in biomarker studies, which are susceptible to the diet the …
Urine-based metabolomics-driven strategies for the discovery of biomarkers are increasingly developed and applied in analytical chemi …
An MMP-degraded and cross-linked fragment of type III collagen as a non-invasive biomarker of hepatic fibrosis resolution.
Pehrsson M, Manon-Jensen T, Sun S, Villesen IF, Castañé H, Joven J, Patel K, Goodman Z, Nielsen MJ, Bay-Jensen AC, Leeming DJ, Mortensen JH, Karsdal MA. Pehrsson M, et al. Liver Int. 2022 Jul;42(7):1605-1617. doi: 10.1111/liv.15270. Epub 2022 Apr 12. Liver Int. 2022. PMID: 35384259 Free PMC article.
We assessed type III collagen remodelling using a panel of biomarkers, including a type III collagen formation marker (PRO-C3), degradation (C3M), and CTX-III (fibrolysis). ...CONCLUSION: Circulating CTX-III as a marker of fibrolysis indicates the biomarker's …
We assessed type III collagen remodelling using a panel of biomarkers, including a type III collagen formation marker (PRO-C3), degra …
Biomarkers in rheumatology, now and in the future.
Gibson DS, Rooney ME, Finnegan S, Qiu J, Thompson DC, Labaer J, Pennington SR, Duncan MW. Gibson DS, et al. Rheumatology (Oxford). 2012 Mar;51(3):423-33. doi: 10.1093/rheumatology/ker358. Epub 2011 Dec 16. Rheumatology (Oxford). 2012. PMID: 22179724 Review.
We define the essential components of the biomarker development pipeline and discuss the issue of fitness for purpose, i.e. what the biomarker(s) might offer in a clinical setting. As a component of this review we also highlight several emerging technologies …
We define the essential components of the biomarker development pipeline and discuss the issue of fitness for purpose, i.e. what the …
Computation and Selection of Optimal Biomarker Combinations by Integrative ROC Analysis Using CombiROC.
Bombaci M, Rossi RL. Bombaci M, et al. Methods Mol Biol. 2019;1959:247-259. doi: 10.1007/978-1-4939-9164-8_16. Methods Mol Biol. 2019. PMID: 30852827
The diagnostic accuracy of biomarker-based approaches can be considerably improved by combining multiple markers. A biomarker's capacity to identify specific subjects is usually assessed using receiver operating characteristic (ROC) curves. ...
The diagnostic accuracy of biomarker-based approaches can be considerably improved by combining multiple markers. A biomarker' …
Avoid using spectrophotometric determination of malondialdehyde as a biomarker of oxidative stress.
Khoubnasabjafari M, Soleymani J, Jouyban A. Khoubnasabjafari M, et al. Biomark Med. 2018 Jun;12(6):551-554. doi: 10.2217/bmm-2017-0437. Epub 2018 Jun 6. Biomark Med. 2018. PMID: 29873547
Despite wide applications of malondialdehyde as a biomarker of oxidative stress, it possesses a number of characteristics that are against its role as a biomarker. ...
Despite wide applications of malondialdehyde as a biomarker of oxidative stress, it possesses a number of characteristics that are ag …
Investigation of peptide biomarker stability in plasma samples using time-course MS analysis.
Yi J, Liu Z, Gelfand CA, Craft D. Yi J, et al. Methods Mol Biol. 2011;728:161-75. doi: 10.1007/978-1-61779-068-3_10. Methods Mol Biol. 2011. PMID: 21468947
Peptide biomarkers in plasma or serum are subject to proteolytic degradation caused by intrinsic peptidase activities, resulting in a potential barrier in translating a discovered biomarker into clinical application. ...This optimized method facilitates evaluation o …
Peptide biomarkers in plasma or serum are subject to proteolytic degradation caused by intrinsic peptidase activities, resulting in a …
Sensitive Detection of the Human Epididymis Protein-4 (HE4) Ovarian Cancer Biomarker through a Sandwich-Type Immunoassay Method with Laser-Induced Breakdown Spectroscopy.
Karunanithy R, Ratnasingam S, Holland T, Sivakumar P. Karunanithy R, et al. Bioconjug Chem. 2023 Mar 15;34(3):501-509. doi: 10.1021/acs.bioconjchem.2c00551. Epub 2023 Feb 10. Bioconjug Chem. 2023. PMID: 36762387
In this study, we report a sandwich-type microparticle immunoassay for sensitive detection of the HE4 biomarker with laser-induced breakdown spectroscopy. Here, we cross-linked elemental particles to a specific functional group of the targeted biomolecules based on a coval …
In this study, we report a sandwich-type microparticle immunoassay for sensitive detection of the HE4 biomarker with laser-induced br …
Quality assurance in biomarker measurement.
[No authors listed] [No authors listed] Toxicol Lett. 1995 May;77(1-3):219-20. Toxicol Lett. 1995. PMID: 7618140 Review. No abstract available.
Enhanced phosphorylation of c-Jun by cisplatin treatment as a potential predictive biomarker for cisplatin response in combination with patient-derived tumor organoids.
Tsukamoto Y, Kurogi S, Shibata T, Suzuki K, Hirashita Y, Fumoto S, Yano S, Yanagihara K, Nakada C, Mieno F, Kinoshita K, Fuchino T, Mizukami K, Ueda Y, Etoh T, Uchida T, Hanada T, Takekawa M, Daa T, Shirao K, Hironaka S, Murakami K, Inomata M, Hijiya N, Moriyama M. Tsukamoto Y, et al. Lab Invest. 2022 Dec;102(12):1355-1366. doi: 10.1038/s41374-022-00827-2. Epub 2022 Aug 3. Lab Invest. 2022. PMID: 35922477 Free article.
Despite recent advances in sequencing technology and large-scale drug screenings employing hundreds of cell lines, the predictive accuracy of mutation-based biomarkers is still insufficient as a guide for cancer therapy. Therefore, novel types of diagnostic methods using a …
Despite recent advances in sequencing technology and large-scale drug screenings employing hundreds of cell lines, the predictive accuracy o …
[Atherosclerosis (hypertension)].
Ai M. Ai M. Nihon Rinsho. 2012 May;70(5):840-5. Nihon Rinsho. 2012. PMID: 22620010 Review. Japanese.
Many studies have shown that atherosclerosis is an inflammatory disease. Therefore biomarkers reflecting the magnitude of inflammation can be also a good marker for atherosclerosis. ...Atherosclerosis is pathologically so complicated that no single biomarker can be …
Many studies have shown that atherosclerosis is an inflammatory disease. Therefore biomarkers reflecting the magnitude of inflammatio …
Update on Biomarkers for the Detection of Endometriosis.
Fassbender A, Burney RO, O DF, D'Hooghe T, Giudice L. Fassbender A, et al. Biomed Res Int. 2015;2015:130854. doi: 10.1155/2015/130854. Epub 2015 Jul 9. Biomed Res Int. 2015. PMID: 26240814 Free PMC article. Review.
However, the invasive nature of surgery, coupled with the lack of a laboratory biomarker for the disease, results in a mean latency of 7-11 years from onset of symptoms to definitive diagnosis. ...In this review, we describe and discuss the current status of biomarkers …
However, the invasive nature of surgery, coupled with the lack of a laboratory biomarker for the disease, results in a mean latency o …
The intricacy of biomarker complexity-the identification of a genuine proteomic biomarker is more complicated than believed.
Büchler R, Wendler S, Muckova P, Großkreutz J, Rhode H. Büchler R, et al. Proteomics Clin Appl. 2016 Nov;10(11):1073-1076. doi: 10.1002/prca.201600067. Epub 2016 Jul 29. Proteomics Clin Appl. 2016. PMID: 27377180
Several reasons have been put forward to explain the irreproducibility of proteomic biomarker search. However, these reasons pertain to almost every part of biomarker search across the entire analytical workflow but are entirely experimental or methodological. ...Th …
Several reasons have been put forward to explain the irreproducibility of proteomic biomarker search. However, these reasons pertain …
Biomarkers in rare neuromuscular diseases.
Scotton C, Passarelli C, Neri M, Ferlini A. Scotton C, et al. Exp Cell Res. 2014 Jul 1;325(1):44-9. doi: 10.1016/j.yexcr.2013.12.020. Epub 2013 Dec 31. Exp Cell Res. 2014. PMID: 24389168 Review.
Furthermore, biomarkers could represent a surrogate endpoint for clinical trials, enabling better stratification of patient cohorts through more accurate diagnosis and prognosis prediction. This review summarizes the types, applications, characteristics and best strategies …
Furthermore, biomarkers could represent a surrogate endpoint for clinical trials, enabling better stratification of patient cohorts t …
Ten Steps to Advance Biomarker Testing.
[No authors listed] [No authors listed] Cancer Discov. 2016 Sep;6(9):940. doi: 10.1158/2159-8290.CD-ND2016-003. Epub 2016 Aug 17. Cancer Discov. 2016. PMID: 27535105
Matching patients with the most effective therapies for their cancer can require testing tumors for genetic mutations or expression of the proteins that certain drugs target. However, tests for these biomarkers can vary in quality, and evidence of their clinical value may …
Matching patients with the most effective therapies for their cancer can require testing tumors for genetic mutations or expression of the p …
Peripheral biomarkers of Alzheimer's disease.
Khan TK, Alkon DL. Khan TK, et al. J Alzheimers Dis. 2015;44(3):729-44. doi: 10.3233/JAD-142262. J Alzheimers Dis. 2015. PMID: 25374110 Review.
CSF biomarkers have received increased attention in the past decade. However, it is unclear whether these biomarkers are capable of early diagnosis of AD, prior to Abeta accumulation, or whether they can differentiate between AD and non-AD dementias. ...This has led …
CSF biomarkers have received increased attention in the past decade. However, it is unclear whether these biomarkers are capab …
Impact of Biomarker-based Design Strategies on the Risk of False-Positive Findings in Targeted Therapy Evaluation.
Vo TT, Vivot A, Porcher R. Vo TT, et al. Clin Cancer Res. 2018 Dec 15;24(24):6257-6264. doi: 10.1158/1078-0432.CCR-18-0328. Epub 2018 Aug 30. Clin Cancer Res. 2018. PMID: 30166443
PURPOSE: When there is more than one potentially predictive biomarker for a new drug, the drug is often evaluated in different subpopulations defined by different biomarkers. ...When the treatment is only effective for some sensitive responders, the third CVASD stra …
PURPOSE: When there is more than one potentially predictive biomarker for a new drug, the drug is often evaluated in different subpop …
Ultrasensitive detection of mucin 1 biomarker by immuno-loop-mediated isothermal amplification.
Cao H, Fang X, Li H, Li H, Kong J. Cao H, et al. Talanta. 2017 Mar 1;164:588-592. doi: 10.1016/j.talanta.2016.07.018. Epub 2016 Jul 5. Talanta. 2017. PMID: 28107977
Mucin 1 (MUC-1), a glycoprotein over-expressed on most malignant epithelial cell surfaces, such as colorectal, lung, prostate, pancreatic, ovarian, and bladder carcinomas, has been confirmed as a useful biomarker for the diagnosis of early cancers. Therefore, it is very im …
Mucin 1 (MUC-1), a glycoprotein over-expressed on most malignant epithelial cell surfaces, such as colorectal, lung, prostate, pancreatic, o …
Biomarker- and similarity coefficient-based approaches to bacterial mixture characterization using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS).
Zhang L, Smart S, Sandrin TR. Zhang L, et al. Sci Rep. 2015 Nov 5;5:15834. doi: 10.1038/srep15834. Sci Rep. 2015. PMID: 26537565 Free PMC article.
Promising results have been reported with two- or three-isolate model systems using biomarker-based approaches. In this work, we applied MALDI-TOF MS-based methods to a more complex model mixture containing six bacteria. ...For two-isolate blind-coded samples, bacteria wer …
Promising results have been reported with two- or three-isolate model systems using biomarker-based approaches. In this work, we appl …
Osteoarthritis Year in Review 2016: biomarkers (biochemical markers).
Mobasheri A, Bay-Jensen AC, van Spil WE, Larkin J, Levesque MC. Mobasheri A, et al. Osteoarthritis Cartilage. 2017 Feb;25(2):199-208. doi: 10.1016/j.joca.2016.12.016. Epub 2017 Jan 16. Osteoarthritis Cartilage. 2017. PMID: 28099838 Free article. Review.
CONCLUSION: There has been steady progress in osteoarthritis (OA) biomarker research in 2016. Several novel biomarkers were identified and new technologies have been developed for measuring existing biomarkers. However, there has been no "quantum leap" this p …
CONCLUSION: There has been steady progress in osteoarthritis (OA) biomarker research in 2016. Several novel biomarkers were id …
Capillary electrophoresis-mass spectrometry, an attractive tool for drug bioanalysis and biomarker discovery.
Servais AC, Crommen J, Fillet M. Servais AC, et al. Electrophoresis. 2006 Jul;27(13):2616-29. doi: 10.1002/elps.200500934. Electrophoresis. 2006. PMID: 16817163 Review.
The second part of the review critically describes the applications of CE coupled on-line to MS for the identification of biomarkers in body fluids for diagnostic purposes. Since the sample preparation procedures strongly differ according to the intended use (drug bioanaly …
The second part of the review critically describes the applications of CE coupled on-line to MS for the identification of biomarkers …
Proteomic strategies for biomarker identification: progress and challenges.
Fung ET, Wright GL Jr, Dalmasso EA. Fung ET, et al. Curr Opin Mol Ther. 2000 Dec;2(6):643-50. Curr Opin Mol Ther. 2000. PMID: 11249741 Review.
The simplest definition of a biomarker is a molecule that indicates an alteration in physiology from normal. ...The need for such biomarkers in all clinical fields is urgent, since the current arsenal of biomarkers is sadly deficient and, in most cases, non-s …
The simplest definition of a biomarker is a molecule that indicates an alteration in physiology from normal. ...The need for such …
Analysis of a urinary biomarker panel for clinical outcomes assessment in cirrhosis.
Ariza X, Solà E, Elia C, Barreto R, Moreira R, Morales-Ruiz M, Graupera I, Rodríguez E, Huelin P, Solé C, Fernández J, Jiménez W, Arroyo V, Ginès P. Ariza X, et al. PLoS One. 2015 Jun 4;10(6):e0128145. doi: 10.1371/journal.pone.0128145. eCollection 2015. PLoS One. 2015. PMID: 26042740 Free PMC article.
Given the large number of biomarkers, adequate choice of which biomarker(s) to investigate first is important. ...Biomarkers with best accuracy for prognosis were those associated with ACLF. ...
Given the large number of biomarkers, adequate choice of which biomarker(s) to investigate first is important. ...Bi …
Overexpression of the GClnc1 as a Diagnostic Biomarker in Gastric Cancer Patients and its Link with H. Pylori Infection.
Riahi A, Moqadami A, ALnajar SGI, Alizadeh M, Rajabi A, Safaralizadeh R. Riahi A, et al. Clin Lab. 2021 Dec 1;67(12). doi: 10.7754/Clin.Lab.2021.210403. Clin Lab. 2021. PMID: 34910430
Eventually, the difference of GClnc1 expression levels in tumor tissue relative to marginal non-tumor tissue specimens of GC patients and its association with pathological characteristics, as well as biomarker's performance of GClnc1, was investigated. RESULTS: Expr …
Eventually, the difference of GClnc1 expression levels in tumor tissue relative to marginal non-tumor tissue specimens of GC patients and it …
Myeloperoxidase, a possible biomarker for the early diagnosis of cardiac diastolic dysfunction with preserved ejection fraction.
Coculescu BI, Dincă GV, Bălăeţ C, Manole G, Bălăeţ M, Stocheci CM. Coculescu BI, et al. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1292-1298. doi: 10.1080/14756366.2018.1499626. J Enzyme Inhib Med Chem. 2018. PMID: 30165747 Free PMC article.
In conclusion, the execution of this investigation triad (electrocardiogram, echocardiography, and MPO) allows: Stratifying the patients depending on the disease risk by early detecting of any possible DD with preserved systolic function. The use of the MPO increased circulating …
In conclusion, the execution of this investigation triad (electrocardiogram, echocardiography, and MPO) allows: Stratifying the patients dep …
Using cardiac biomarkers in veterinary practice.
Oyama MA. Oyama MA. Vet Clin North Am Small Anim Pract. 2013 Nov;43(6):1261-72, vi. doi: 10.1016/j.cvsm.2013.07.010. Epub 2013 Aug 2. Vet Clin North Am Small Anim Pract. 2013. PMID: 24144089 Review.
Blood-based assays for various cardiac biomarkers can assist in the diagnosis of heart disease in dogs and cats. ...Usage of cardiac biomarker testing in clinical practice relies on proper patient selection, correct interpretation of test results, and incorporation …
Blood-based assays for various cardiac biomarkers can assist in the diagnosis of heart disease in dogs and cats. ...Usage of cardiac …
Predictive biomarkers for treatment selection: statistical considerations.
Chen JJ, Lu TP, Chen YC, Lin WJ. Chen JJ, et al. Biomark Med. 2015;9(11):1121-35. doi: 10.2217/bmm.15.84. Epub 2015 Oct 28. Biomark Med. 2015. PMID: 26507127 Free article. Review.
Predictive biomarkers are developed for treatment selection to identify patients who are likely to benefit from a particular therapy. ...Major statistical issues discussed include biomarker designs, procedures to identify predictive biomarkers, classification …
Predictive biomarkers are developed for treatment selection to identify patients who are likely to benefit from a particular therapy. …
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