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Year Number of Results
2006 1
2008 3
2010 2
2011 2
2012 10
2013 6
2014 6
2015 4
2016 9
2017 6
2018 7
2019 7
2020 10
2021 16
2022 17
2023 21
2024 6

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119 results

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Page 1
Development and validation of an ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of the antimalarial drug pyronaridine in human whole blood.
Schouten WM, Roseboom IC, Lucas L, Kabalu Tshiongo J, Muhindo Mavoko H, Kayentao K, Rosing H, Huitema ADR, Beijnen JH, Dorlo TPC. Schouten WM, et al. J Pharm Biomed Anal. 2024 Apr 16;245:116154. doi: 10.1016/j.jpba.2024.116154. Online ahead of print. J Pharm Biomed Anal. 2024. PMID: 38657367 Free article.
Leishmania blood parasite dynamics during and after treatment of visceral leishmaniasis in Eastern Africa: A pharmacokinetic-pharmacodynamic model.
Verrest L, Monnerat S, Musa AM, Mbui J, Khalil EAG, Olobo J, Wasunna M, Chu WY, Huitema ADR, Schallig HDFH, Alves F, Dorlo TPC. Verrest L, et al. PLoS Negl Trop Dis. 2024 Apr 19;18(4):e0012078. doi: 10.1371/journal.pntd.0012078. eCollection 2024 Apr. PLoS Negl Trop Dis. 2024. PMID: 38640118 Free PMC article.
Safety and efficacy of paromomycin/miltefosine/liposomal amphotericin B combinations for the treatment of post-kala-azar dermal leishmaniasis in Sudan: A phase II, open label, randomized, parallel arm study.
Younis BM, Mudawi Musa A, Monnerat S, Abdelrahim Saeed M, Awad Gasim Khalil E, Elbashir Ahmed A, Ahmed Ali M, Noureldin A, Muthoni Ouattara G, Nyakaya GM, Teshome S, Omollo T, Ochieng M, Egondi T, Mmbone M, Chu WY, Dorlo TPC, Zijlstra EE, Wasunna M, Alvar J, Alves F. Younis BM, et al. PLoS Negl Trop Dis. 2023 Nov 21;17(11):e0011780. doi: 10.1371/journal.pntd.0011780. eCollection 2023 Nov. PLoS Negl Trop Dis. 2023. PMID: 37988402 Free PMC article. Clinical Trial.
Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial.
Djimde M, Tshiongo JK, Muhindo HM, Tinto H, Sevene E, Traore M, Vala A, Macuacua S, Kabore B, Dabira ED, Erhart A, Diakite H, Keita M, Piqueras M, González R, Menendez C, Dorlo TP, Sagara I, Mens P, Schallig H, D'Alessandro U, Kayentao K. Djimde M, et al. BMJ Open. 2023 Oct 9;13(10):e065295. doi: 10.1136/bmjopen-2022-065295. BMJ Open. 2023. PMID: 37813539 Free PMC article.
Population pharmacokinetics of a combination of miltefosine and paromomycin in Eastern African children and adults with visceral leishmaniasis.
Verrest L, Roseboom IC, Wasunna M, Mbui J, Njenga S, Musa AM, Olobo J, Mohammed R, Ritmeijer K, Chu WY, Huitema ADR, Solomos A, Alves F, Dorlo TPC. Verrest L, et al. J Antimicrob Chemother. 2023 Nov 6;78(11):2702-2714. doi: 10.1093/jac/dkad286. J Antimicrob Chemother. 2023. PMID: 37726401 Free PMC article. Clinical Trial.
High accumulation of nivolumab in human breast milk: A case report.
de Jong K, Damoiseaux D, Pluim D, Rosing H, Beijnen JH, van Thienen H, Dorlo TPC, Huitema ADR, Amant F. de Jong K, et al. Biomed Pharmacother. 2023 Oct;166:115354. doi: 10.1016/j.biopha.2023.115354. Epub 2023 Aug 23. Biomed Pharmacother. 2023. PMID: 37625324 Free article.
Population pharmacokinetic dosimetry model using imaging data to assess variability in pharmacokinetics of 177 Lu-PSMA-617 in prostate cancer patients.
Siebinga H, Privé BM, Peters SMB, Nagarajah J, Dorlo TPC, Huitema ADR, de Wit-van der Veen BJ, Hendrikx JJMA. Siebinga H, et al. CPT Pharmacometrics Syst Pharmacol. 2023 Aug;12(8):1060-1071. doi: 10.1002/psp4.12914. Epub 2023 Feb 9. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 36760133 Free PMC article.
Development and validation of an ultra-high performance liquid chromatography coupled to tandem mass spectrometry method for the quantification of the antileishmanial drug paromomycin in human skin tissue.
Roseboom IC, Thijssen B, Rosing H, Alves F, Younis BM, Musa AM, Beijnen JH, Dorlo TPC. Roseboom IC, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2022 Nov 15;1211:123494. doi: 10.1016/j.jchromb.2022.123494. Epub 2022 Oct 7. J Chromatogr B Analyt Technol Biomed Life Sci. 2022. PMID: 36219923 Free article.
Paromomycin and Miltefosine Combination as an Alternative to Treat Patients With Visceral Leishmaniasis in Eastern Africa: A Randomized, Controlled, Multicountry Trial.
Musa AM, Mbui J, Mohammed R, Olobo J, Ritmeijer K, Alcoba G, Muthoni Ouattara G, Egondi T, Nakanwagi P, Omollo T, Wasunna M, Verrest L, Dorlo TPC, Musa Younis B, Nour A, Taha Ahmed Elmukashfi E, Ismail Omer Haroun A, Khalil EAG, Njenga S, Fikre H, Mekonnen T, Mersha D, Sisay K, Sagaki P, Alvar J, Solomos A, Alves F. Musa AM, et al. Clin Infect Dis. 2023 Feb 8;76(3):e1177-e1185. doi: 10.1093/cid/ciac643. Clin Infect Dis. 2023. PMID: 36164254 Free PMC article. Clinical Trial.
Development and validation of a high-performance liquid chromatography tandem mass spectrometry method for the quantification of the antiparasitic and antifungal drug amphotericin B in human skin tissue.
Roseboom IC, Thijssen B, Rosing H, Alves F, Sundar S, Beijnen JH, Dorlo TPC. Roseboom IC, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2022 Aug 15;1206:123354. doi: 10.1016/j.jchromb.2022.123354. Epub 2022 Jul 4. J Chromatogr B Analyt Technol Biomed Life Sci. 2022. PMID: 35810536 Free article.
Development of a population pharmacokinetic/pharmacodynamic model for various oral paclitaxel formulations co-administered with ritonavir and thrombospondin-1 based on data from early phase clinical studies.
van Eijk M, Yu H, Sawicki E, de Weger VA, Nuijen B, Dorlo TPC, Beijnen JH, Huitema ADR. van Eijk M, et al. Cancer Chemother Pharmacol. 2022 Jul;90(1):71-82. doi: 10.1007/s00280-022-04445-z. Epub 2022 Jul 7. Cancer Chemother Pharmacol. 2022. PMID: 35799067 Free PMC article.
No evidence for cardiotoxicity of miltefosine.
Dorlo TPC. Dorlo TPC. An Bras Dermatol. 2022 Jul-Aug;97(4):548-549. doi: 10.1016/j.abd.2022.03.002. Epub 2022 May 30. An Bras Dermatol. 2022. PMID: 35654652 Free PMC article. No abstract available.
Pharmacokinetic/Pharmacodynamic Modelling of Allopurinol, its Active Metabolite Oxypurinol, and Biomarkers Hypoxanthine, Xanthine and Uric Acid in Hypoxic-Ischemic Encephalopathy Neonates.
Chu WY, Annink KV, Nijstad AL, Maiwald CA, Schroth M, Bakkali LE, van Bel F, Benders MJNL, van Weissenbruch MM, Hagen A, Franz AR, Dorlo TPC, Allegaert K, Huitema ADR; ALBINO Study Group. Chu WY, et al. Clin Pharmacokinet. 2022 Feb;61(2):321-333. doi: 10.1007/s40262-021-01068-0. Epub 2021 Oct 7. Clin Pharmacokinet. 2022. PMID: 34617261 Free PMC article. Clinical Trial.
Geographical Variability in Paromomycin Pharmacokinetics Does Not Explain Efficacy Differences between Eastern African and Indian Visceral Leishmaniasis Patients.
Verrest L, Wasunna M, Kokwaro G, Aman R, Musa AM, Khalil EAG, Mudawi M, Younis BM, Hailu A, Hurissa Z, Hailu W, Tesfaye S, Makonnen E, Mekonnen Y, Huitema ADR, Beijnen JH, Kshirsagar SA, Chakravarty J, Rai M, Sundar S, Alves F, Dorlo TPC. Verrest L, et al. Clin Pharmacokinet. 2021 Nov;60(11):1463-1473. doi: 10.1007/s40262-021-01036-8. Epub 2021 Jun 9. Clin Pharmacokinet. 2021. PMID: 34105063 Free PMC article.
Population Pharmacokinetics of Docetaxel, Paclitaxel, Doxorubicin and Epirubicin in Pregnant Women with Cancer: A Study from the International Network of Cancer, Infertility and Pregnancy (INCIP).
Janssen JM, Van Calsteren K, Dorlo TPC, Halaska MJ, Fruscio R, Ottevanger P, Schröder CP, Boere I, Witteveen PO, Painter RC, Bekkers R, Drochytek V, Beijnen JH, Huitema ADR, Amant FCH. Janssen JM, et al. Clin Pharmacokinet. 2021 Jun;60(6):775-784. doi: 10.1007/s40262-020-00961-4. Epub 2021 Jan 28. Clin Pharmacokinet. 2021. PMID: 33506375
Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors.
Schmidt KT, Huitema ADR, Dorlo TPC, Peer CJ, Cordes LM, Sciuto L, Wroblewski S, Pommier Y, Madan RA, Thomas A, Figg WD. Schmidt KT, et al. Cancer Chemother Pharmacol. 2020 Oct;86(4):475-486. doi: 10.1007/s00280-020-04134-9. Epub 2020 Sep 8. Cancer Chemother Pharmacol. 2020. PMID: 32897402 Free PMC article. Clinical Trial.
A Semi-Mechanistic Population Pharmacokinetic/Pharmacodynamic Model of Bortezomib in Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia.
Janssen JM, Dorlo TPC, Niewerth D, Wilhelm AJ, Zwaan CM, Beijnen JH, Attarbaschi A, Baruchel A, Fagioli F, Klingebiel T, De Moerloose B, Palumbo G, von Stackelberg A, Kaspers GJL, Huitema ADR. Janssen JM, et al. Clin Pharmacokinet. 2020 Feb;59(2):207-216. doi: 10.1007/s40262-019-00803-y. Clin Pharmacokinet. 2020. PMID: 31313068 Clinical Trial.
Pharmacokinetics, Safety, and Efficacy of an Allometric Miltefosine Regimen for the Treatment of Visceral Leishmaniasis in Eastern African Children: An Open-label, Phase II Clinical Trial.
Mbui J, Olobo J, Omollo R, Solomos A, Kip AE, Kirigi G, Sagaki P, Kimutai R, Were L, Omollo T, Egondi TW, Wasunna M, Alvar J, Dorlo TPC, Alves F. Mbui J, et al. Clin Infect Dis. 2019 Apr 24;68(9):1530-1538. doi: 10.1093/cid/ciy747. Clin Infect Dis. 2019. PMID: 30188978 Free PMC article. Clinical Trial.
Simultaneous population pharmacokinetic modelling of plasma and intracellular PBMC miltefosine concentrations in New World cutaneous leishmaniasis and exploration of exposure-response relationships.
Kip AE, Castro MDM, Gomez MA, Cossio A, Schellens JHM, Beijnen JH, Saravia NG, Dorlo TPC. Kip AE, et al. J Antimicrob Chemother. 2018 Aug 1;73(8):2104-2111. doi: 10.1093/jac/dky143. J Antimicrob Chemother. 2018. PMID: 29757380 Free PMC article. Clinical Trial.
Visceral leishmaniasis relapse hazard is linked to reduced miltefosine exposure in patients from Eastern Africa: a population pharmacokinetic/pharmacodynamic study.
Dorlo TPC, Kip AE, Younis BM, Ellis SJ, Alves F, Beijnen JH, Njenga S, Kirigi G, Hailu A, Olobo J, Musa AM, Balasegaram M, Wasunna M, Karlsson MO, Khalil EAG. Dorlo TPC, et al. J Antimicrob Chemother. 2017 Nov 1;72(11):3131-3140. doi: 10.1093/jac/dkx283. J Antimicrob Chemother. 2017. PMID: 28961737 Free PMC article. Clinical Trial.
Efficacy and Safety of AmBisome in Combination with Sodium Stibogluconate or Miltefosine and Miltefosine Monotherapy for African Visceral Leishmaniasis: Phase II Randomized Trial.
Wasunna M, Njenga S, Balasegaram M, Alexander N, Omollo R, Edwards T, Dorlo TP, Musa B, Ali MH, Elamin MY, Kirigi G, Juma R, Kip AE, Schoone GJ, Hailu A, Olobo J, Ellis S, Kimutai R, Wells S, Khalil EA, Strub Wourgaft N, Alves F, Musa A. Wasunna M, et al. PLoS Negl Trop Dis. 2016 Sep 14;10(9):e0004880. doi: 10.1371/journal.pntd.0004880. eCollection 2016 Sep. PLoS Negl Trop Dis. 2016. PMID: 27627654 Free PMC article. Clinical Trial.
Treatment of visceral leishmaniasis: pitfalls and stewardship.
Dorlo TPC, Ostyn BA, Uranw S, Dujardin JC, Boelaert M. Dorlo TPC, et al. Lancet Infect Dis. 2016 Jul;16(7):777-778. doi: 10.1016/S1473-3099(16)30091-3. Lancet Infect Dis. 2016. PMID: 27352756 No abstract available.
Assessment of blood-brain barrier penetration of miltefosine used to treat a fatal case of granulomatous amebic encephalitis possibly caused by an unusual Balamuthia mandrillaris strain.
Roy SL, Atkins JT, Gennuso R, Kofos D, Sriram RR, Dorlo TP, Hayes T, Qvarnstrom Y, Kucerova Z, Guglielmo BJ, Visvesvara GS. Roy SL, et al. Parasitol Res. 2015 Dec;114(12):4431-9. doi: 10.1007/s00436-015-4684-8. Epub 2015 Sep 2. Parasitol Res. 2015. PMID: 26329128 Free PMC article.
Safety and efficacy of single dose versus multiple doses of AmBisome for treatment of visceral leishmaniasis in eastern Africa: a randomised trial.
Khalil EA, Weldegebreal T, Younis BM, Omollo R, Musa AM, Hailu W, Abuzaid AA, Dorlo TP, Hurissa Z, Yifru S, Haleke W, Smith PG, Ellis S, Balasegaram M, EL-Hassan AM, Schoone GJ, Wasunna M, Kimutai R, Edwards T, Hailu A. Khalil EA, et al. PLoS Negl Trop Dis. 2014 Jan 16;8(1):e2613. doi: 10.1371/journal.pntd.0002613. eCollection 2014. PLoS Negl Trop Dis. 2014. PMID: 24454970 Free PMC article. Clinical Trial.
Reply to Arya and Agarwal.
Dorlo TP, Ostyn BA, Beijnen JH, Boelaert M, Dujardin JC, Rijal S. Dorlo TP, et al. Clin Infect Dis. 2013 Sep;57(6):917-8. doi: 10.1093/cid/cit388. Epub 2013 Jun 11. Clin Infect Dis. 2013. PMID: 23759350 No abstract available.
The global impact of Indian generics on access to health.
Ravinetto RM, Dorlo TP, Caudron JM, Prashanth NS. Ravinetto RM, et al. Indian J Med Ethics. 2013 Apr-Jun;10(2):118-20. doi: 10.20529/IJME.2013.035. Indian J Med Ethics. 2013. PMID: 23697493 Free article. No abstract available.
Lopinavir/ritonavir significantly influences pharmacokinetic exposure of artemether/lumefantrine in HIV-infected Ugandan adults.
Byakika-Kibwika P, Lamorde M, Okaba-Kayom V, Mayanja-Kizza H, Katabira E, Hanpithakpong W, Pakker N, Dorlo TP, Tarning J, Lindegardh N, de Vries PJ, Back D, Khoo S, Merry C. Byakika-Kibwika P, et al. J Antimicrob Chemother. 2012 May;67(5):1217-23. doi: 10.1093/jac/dkr596. Epub 2012 Feb 8. J Antimicrob Chemother. 2012. PMID: 22316571 Free PMC article. Clinical Trial.
Safety and efficacy of miltefosine alone and in combination with sodium stibogluconate and liposomal amphotericin B for the treatment of primary visceral leishmaniasis in East Africa: study protocol for a randomized controlled trial.
Omollo R, Alexander N, Edwards T, Khalil EA, Younis BM, Abuzaid AA, Wasunna M, Njoroge N, Kinoti D, Kirigi G, Dorlo TP, Ellis S, Balasegaram M, Musa AM. Omollo R, et al. Trials. 2011 Jun 30;12:166. doi: 10.1186/1745-6215-12-166. Trials. 2011. PMID: 21718522 Free PMC article. Clinical Trial.
Pharmacokinetics of miltefosine in Old World cutaneous leishmaniasis patients.
Dorlo TP, van Thiel PP, Huitema AD, Keizer RJ, de Vries HJ, Beijnen JH, de Vries PJ. Dorlo TP, et al. Antimicrob Agents Chemother. 2008 Aug;52(8):2855-60. doi: 10.1128/AAC.00014-08. Epub 2008 Jun 2. Antimicrob Agents Chemother. 2008. PMID: 18519729 Free PMC article. Clinical Trial.
Pentamidine dosage: a base/salt confusion.
Dorlo TP, Kager PA. Dorlo TP, et al. PLoS Negl Trop Dis. 2008 May 28;2(5):e225. doi: 10.1371/journal.pntd.0000225. PLoS Negl Trop Dis. 2008. PMID: 18509543 Free PMC article.
[Miltefosine: a new remedy for leishmaniasis].
Dorlo TP, Eggelte TA, Beijnen JH, de Vries PJ. Dorlo TP, et al. Ned Tijdschr Geneeskd. 2006 Dec 9;150(49):2697-701. Ned Tijdschr Geneeskd. 2006. PMID: 17194005 Review. Dutch.