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Page 1
Skin Rejuvenation through HIF-1alpha Modulation.
Pagani A, Aitzetmüller MM, Brett EA, König V, Wenny R, Thor D, Radtke C, Huemer GM, Machens HG, Duscher D. Pagani A, et al. Plast Reconstr Surg. 2018 Apr;141(4):600e-607e. doi: 10.1097/PRS.0000000000004256. Plast Reconstr Surg. 2018. PMID: 29596193 Review.
Dysfunction of a main response-to-injury pathway, the hypoxia-inducible factor (HIF)-1alpha regulatory pathway, has been identified as pivotal both in chronic wounds and in aging skin degeneration. HIF-1alpha signaling is significantly involved in tissue homeostasis …
Dysfunction of a main response-to-injury pathway, the hypoxia-inducible factor (HIF)-1alpha regulatory pathway, has been identified a …
Deferiprone Stimulates Aged Dermal Fibroblasts via HIF-1alpha Modulation.
Pagani A, Kirsch BM, Hopfner U, Aitzetmueller MM, Brett EA, Thor D, Mela P, Machens HG, Duscher D. Pagani A, et al. Aesthet Surg J. 2021 Mar 12;41(4):514-524. doi: 10.1093/asj/sjaa142. Aesthet Surg J. 2021. PMID: 32479616
BACKGROUND: Hypoxia-inducible factor 1alpha (HIF-1alpha), a transcription factor responsible for tissue homeostasis and regeneration, presents reduced functionality in advanced age. ...Modulation of HIF-1alpha is linked to activation of key regeneration enzymes and …
BACKGROUND: Hypoxia-inducible factor 1alpha (HIF-1alpha), a transcription factor responsible for tissue homeostasis and regeneration, …
The Role of Hypoxia-Inducible Factor in Wound Healing.
Hong WX, Hu MS, Esquivel M, Liang GY, Rennert RC, McArdle A, Paik KJ, Duscher D, Gurtner GC, Lorenz HP, Longaker MT. Hong WX, et al. Adv Wound Care (New Rochelle). 2014 May 1;3(5):390-399. doi: 10.1089/wound.2013.0520. Adv Wound Care (New Rochelle). 2014. PMID: 24804159 Free PMC article. Review.
Both positive and negative regulators of HIF-1 therefore provide important therapeutic targets that can be used to manipulate HIF-1 expression where an excess or deficiency in HIF-1 is known to correlate with pathogenesis. ...Counteracting the detrimental eff …
Both positive and negative regulators of HIF-1 therefore provide important therapeutic targets that can be used to manipulate HIF …
HIF-1alpha Stimulators Function Equally to Leading Hair Loss Agents in Enhancing Dermal Papilla Growth.
Bukowiecki J, Pförringer D, Thor D, Duscher D, Brett E. Bukowiecki J, et al. Skin Pharmacol Physiol. 2020;33(6):309-316. doi: 10.1159/000512123. Epub 2020 Dec 16. Skin Pharmacol Physiol. 2020. PMID: 33326985
During this process the hair follicle loses nutrition over time and eventually dies, causing the hair to fall out. Recent evidence suggests that hypoxia-inducible factor-1a (HIF-1alpha) modulation may counteract hair loss. This study aims to evaluate the proliferation of d …
During this process the hair follicle loses nutrition over time and eventually dies, causing the hair to fall out. Recent evidence suggests …
Transdermal deferoxamine prevents pressure-induced diabetic ulcers.
Duscher D, Neofytou E, Wong VW, Maan ZN, Rennert RC, Inayathullah M, Januszyk M, Rodrigues M, Malkovskiy AV, Whitmore AJ, Walmsley GG, Galvez MG, Whittam AJ, Brownlee M, Rajadas J, Gurtner GC. Duscher D, et al. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):94-9. doi: 10.1073/pnas.1413445112. Epub 2014 Dec 22. Proc Natl Acad Sci U S A. 2015. PMID: 25535360 Free PMC article.
A major factor underlying this is reduced neovascularization caused by impaired activity of the transcription factor hypoxia inducible factor-1 alpha (HIF-1alpha). In diabetes, HIF-1alpha function is compromised by a high glucose-induced and reactive oxygen species- …
A major factor underlying this is reduced neovascularization caused by impaired activity of the transcription factor hypoxia inducible facto …
Fibroblast-Specific Deletion of Hypoxia Inducible Factor-1 Critically Impairs Murine Cutaneous Neovascularization and Wound Healing.
Duscher D, Maan ZN, Whittam AJ, Sorkin M, Hu MS, Walmsley GG, Baker H, Fischer LH, Januszyk M, Wong VW, Gurtner GC. Duscher D, et al. Plast Reconstr Surg. 2015 Nov;136(5):1004-1013. doi: 10.1097/PRS.0000000000001699. Plast Reconstr Surg. 2015. PMID: 26505703 Free PMC article.
To better understand the role of this master hypoxia regulator within cutaneous tissue, the authors generated and evaluated a fibroblast-specific HIF-1alpha knockout mouse model. METHODS: The authors generated floxed HIF-1 mice (HIF-1) by introducing loxP sit …
To better understand the role of this master hypoxia regulator within cutaneous tissue, the authors generated and evaluated a fibroblast-spe …
Optimization of transdermal deferoxamine leads to enhanced efficacy in healing skin wounds.
Duscher D, Trotsyuk AA, Maan ZN, Kwon SH, Rodrigues M, Engel K, Stern-Buchbinder ZA, Bonham CA, Barrera J, Whittam AJ, Hu MS, Inayathullah M, Rajadas J, Gurtner GC. Duscher D, et al. J Control Release. 2019 Aug 28;308:232-239. doi: 10.1016/j.jconrel.2019.07.009. Epub 2019 Jul 9. J Control Release. 2019. PMID: 31299261
Deferoxamine (DFO), an iron-chelating agent clinically used to treat iron toxicity, has been shown to reduce oxidative stress and increase hypoxia-inducible factor-1 alpha (HIF-1alpha) activation, thereby promoting neovascularization and enhancing regeneration in chronic w …
Deferoxamine (DFO), an iron-chelating agent clinically used to treat iron toxicity, has been shown to reduce oxidative stress and increase h …
Short Hairpin RNA Silencing of PHD-2 Improves Neovascularization and Functional Outcomes in Diabetic Wounds and Ischemic Limbs.
Paik KJ, Maan ZN, Zielins ER, Duscher D, Whittam AJ, Morrison SD, Brett EA, Ransom RC, Hu MS, Wu JC, Gurtner GC, Longaker MT, Wan DC. Paik KJ, et al. PLoS One. 2016 Mar 11;11(3):e0150927. doi: 10.1371/journal.pone.0150927. eCollection 2016. PLoS One. 2016. PMID: 26967994 Free PMC article.
However, under normoxic conditions, HIF-1alpha is hydroxylated by prolyl hydroxylase 2, and subsequently degraded, with a biological half-life of less than five minutes. ...Knockdown of PHD-2 through shRNA treatment has the potential to stimulate angiogenesis through overe …
However, under normoxic conditions, HIF-1alpha is hydroxylated by prolyl hydroxylase 2, and subsequently degraded, with a biological …
A Novel Hair Restoration Technology Counteracts Androgenic Hair Loss and Promotes Hair Growth in A Blinded Clinical Trial.
Thor D, Pagani A, Bukowiecki J, Houschyar KS, Kølle ST, Wyles SP, Duscher D. Thor D, et al. J Clin Med. 2023 Jan 6;12(2):470. doi: 10.3390/jcm12020470. J Clin Med. 2023. PMID: 36675398 Free PMC article.
During this process, the hair follicle suffers from increasing malnutrition and eventually dies, causing progressive hair loss. We recently highlighted that HIF-1alpha modulation may counteract hair loss. Here, we aim to demonstrate the positive influence of Tomorrowlabs …
During this process, the hair follicle suffers from increasing malnutrition and eventually dies, causing progressive hair loss. We recently …
A single-center blinded randomized clinical trial to evaluate the anti-aging effects of a novel HSF™-based skin care formulation.
Duscher D, Maan ZN, Hu MS, Thor D. Duscher D, et al. J Cosmet Dermatol. 2020 Nov;19(11):2936-2945. doi: 10.1111/jocd.13356. Epub 2020 Apr 19. J Cosmet Dermatol. 2020. PMID: 32306525 Clinical Trial.
BACKGROUND: Similar to chronic wounds, skin aging is characterized by dysfunction of key cellular regulatory pathways. The hypoxia-inducible factor-1 alpha (HIF-1alpha) pathway was linked to both conditions. Recent evidence suggests that modulating this pathway can rejuven …
BACKGROUND: Similar to chronic wounds, skin aging is characterized by dysfunction of key cellular regulatory pathways. The hypoxia-inducible …
11 results