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Year Number of Results
1993 10
1994 1
1995 4
1996 3
1997 3
1998 3
1999 3
2000 28
2001 40
2002 45
2003 80
2004 68
2005 73
2006 87
2007 145
2008 144
2009 130
2010 121
2011 139
2012 154
2013 166
2014 167
2015 181
2016 210
2017 228
2018 246
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2024 128

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3,509 results

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The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial.
Marson A, Burnside G, Appleton R, Smith D, Leach JP, Sills G, Tudur-Smith C, Plumpton C, Hughes DA, Williamson P, Baker GA, Balabanova S, Taylor C, Brown R, Hindley D, Howell S, Maguire M, Mohanraj R, Smith PE; SANAD II collaborators. Marson A, et al. Lancet. 2021 Apr 10;397(10282):1375-1386. doi: 10.1016/S0140-6736(21)00246-4. Lancet. 2021. PMID: 33838758 Free PMC article. Clinical Trial.
We aimed to compare the long-term clinical effectiveness and cost-effectiveness of levetiracetam compared with valproate in participants with newly diagnosed generalised or unclassifiable epilepsy. METHODS: We did an open-label, randomised controlled trial to compar …
We aimed to compare the long-term clinical effectiveness and cost-effectiveness of levetiracetam compared with valproate in participa …
Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs.
Marson AG, Burnside G, Appleton R, Smith D, Leach JP, Sills G, Tudur-Smith C, Plumpton CO, Hughes DA, Williamson PR, Baker G, Balabanova S, Taylor C, Brown R, Hindley D, Howell S, Maguire M, Mohanraj R, Smith PE. Marson AG, et al. Health Technol Assess. 2021 Dec;25(75):1-134. doi: 10.3310/hta25750. Health Technol Assess. 2021. PMID: 34931602 Free article. Clinical Trial.
Ltd, Tokyo, Japan) are licensed as monotherapy for focal epilepsy, and levetiracetam is increasingly used as a first-line treatment for generalised epilepsy, particularly for women of childbearing age. ...Generalised and unclassifiable epilepsy - The S …
Ltd, Tokyo, Japan) are licensed as monotherapy for focal epilepsy, and levetiracetam is increasingly used as a first-line trea …
The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial.
Marson A, Burnside G, Appleton R, Smith D, Leach JP, Sills G, Tudur-Smith C, Plumpton C, Hughes DA, Williamson P, Baker GA, Balabanova S, Taylor C, Brown R, Hindley D, Howell S, Maguire M, Mohanraj R, Smith PE; SANAD II collaborators. Marson A, et al. Lancet. 2021 Apr 10;397(10282):1363-1374. doi: 10.1016/S0140-6736(21)00247-6. Lancet. 2021. PMID: 33838757 Free PMC article. Clinical Trial.
We aimed to assess the long-term clinical effectiveness and cost-effectiveness of levetiracetam and zonisamide compared with lamotrigine in people with newly diagnosed focal epilepsy. ...INTERPRETATION: These findings do not support the use of levetiracetam o …
We aimed to assess the long-term clinical effectiveness and cost-effectiveness of levetiracetam and zonisamide compared with lamotrig …
Levetiracetam in childhood epilepsy.
Verrotti A, D'Adamo E, Parisi P, Chiarelli F, Curatolo P. Verrotti A, et al. Paediatr Drugs. 2010 Jun;12(3):177-86. doi: 10.2165/11316250-000000000-00000. Paediatr Drugs. 2010. PMID: 20486734 Review.
We have reviewed the available data on the efficacy, tolerability, and safety of levetiracetam in children with epilepsy. The efficacy of levetiracetam as an adjunctive therapy and as monotherapy for generalized and partial childhood epilepsies and for …
We have reviewed the available data on the efficacy, tolerability, and safety of levetiracetam in children with epilepsy. The …
Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial.
Sharpe C, Reiner GE, Davis SL, Nespeca M, Gold JJ, Rasmussen M, Kuperman R, Harbert MJ, Michelson D, Joe P, Wang S, Rismanchi N, Le NM, Mower A, Kim J, Battin MR, Lane B, Honold J, Knodel E, Arnell K, Bridge R, Lee L, Ernstrom K, Raman R, Haas RH; NEOLEV2 INVESTIGATORS. Sharpe C, et al. Pediatrics. 2020 Jun;145(6):e20193182. doi: 10.1542/peds.2019-3182. Epub 2020 May 8. Pediatrics. 2020. PMID: 32385134 Free PMC article. Clinical Trial.
However, randomized studies have not been performed. Our objectives were to study the efficacy and safety of levetiracetam compared with phenobarbital as a first-line treatment of neonatal seizures. ...Higher-dose studies of levetiracetam are warranted, and definiti …
However, randomized studies have not been performed. Our objectives were to study the efficacy and safety of levetiracetam compared w …
Levetiracetam versus Oxcarbazepine as monotherapy in newly diagnosed focal epilepsy: A systematic review and meta-analysis.
Kharel S, Ojha R, Khanal S. Kharel S, et al. Brain Behav. 2022 Nov;12(11):e2779. doi: 10.1002/brb3.2779. Epub 2022 Oct 2. Brain Behav. 2022. PMID: 36184821 Free PMC article. Review.
OBJECTIVE: To compare the efficacy and safety of Levetiracetam (LEV) and Oxcarbazepine (OXC) as monotherapy for the treatment of newly diagnosed focal epilepsy. ...RESULTS: Two RCTs included a total of 574 newly diagnosed focal epilepsy patients (the LEV grou …
OBJECTIVE: To compare the efficacy and safety of Levetiracetam (LEV) and Oxcarbazepine (OXC) as monotherapy for the treatment of newl …
Levetiracetam vs Lamotrigine as First-Line Antiseizure Medication in Female Patients With Idiopathic Generalized Epilepsy.
Cerulli Irelli E, Cocchi E, Morano A, Gesche J, Caraballo RH, Lattanzi S, Strigaro G, Catania C, Ferlazzo E, Pascarella A, Casciato S, Quarato P, Pizzanelli C, Pulitano P, Giuliano L, Viola V, Mostacci B, Fortunato F, Marini C, Di Gennaro G, Gambardella A, Labate A, Operto FF, Giallonardo AT, Baykan B, Beier CP, Di Bonaventura C; Women With Epilepsy Treatment Options and Research (WETOR) Study Group. Cerulli Irelli E, et al. JAMA Neurol. 2023 Nov 1;80(11):1174-1181. doi: 10.1001/jamaneurol.2023.3400. JAMA Neurol. 2023. PMID: 37782485
Patients were recruited from 22 primary, secondary, and tertiary adult and child epilepsy centers from 4 countries. Eligible patients were female individuals of childbearing age, diagnosed with IGE according to International League Against Epilepsy (2022) criteria a …
Patients were recruited from 22 primary, secondary, and tertiary adult and child epilepsy centers from 4 countries. Eligible patients …
Management of epilepsy in brain tumor patients.
van der Meer PB, Taphoorn MJB, Koekkoek JAF. van der Meer PB, et al. Curr Opin Oncol. 2022 Nov 1;34(6):685-690. doi: 10.1097/CCO.0000000000000876. Epub 2022 Jul 16. Curr Opin Oncol. 2022. PMID: 35838207 Free PMC article. Review.
PURPOSE OF REVIEW: A concise review of recent findings in brain tumor-related epilepsy (BTRE), with focus on the effect of antitumor treatment on seizure control and the management of antiepileptic drugs (AEDs). ...SUMMARY: Management of seizures in BTRE is complex and wit …
PURPOSE OF REVIEW: A concise review of recent findings in brain tumor-related epilepsy (BTRE), with focus on the effect of antitumor …
Combined effects of levetiracetam and sodium valproate on paediatric patients with epilepsy: a systematic review and meta-analysis.
Zhu Y, Yang J, Zhu X. Zhu Y, et al. Seizure. 2022 Feb;95:17-25. doi: 10.1016/j.seizure.2021.12.003. Epub 2021 Dec 21. Seizure. 2022. PMID: 34971912 Free article. Review.
OBJECTIVE: To estimate the safety and efficacy of sodium valproate combined with levetiracetam in paediatric patients with epilepsy based on randomized controlled trials (RCTs). ...Therefore, we recommend sodium valproate combined with levetiracetam for the t …
OBJECTIVE: To estimate the safety and efficacy of sodium valproate combined with levetiracetam in paediatric patients with epileps
Epilepsy and brain tumors: Two sides of the same coin.
Aronica E, Ciusani E, Coppola A, Costa C, Russo E, Salmaggi A, Perversi F, Maschio M. Aronica E, et al. J Neurol Sci. 2023 Mar 15;446:120584. doi: 10.1016/j.jns.2023.120584. Epub 2023 Feb 13. J Neurol Sci. 2023. PMID: 36842341 Free article. Review.
Epilepsy is the most common symptom in patients with brain tumors. ...Low-grade developmental brain tumors are those most commonly associated with epilepsy. Given this strict relationship, drugs able to target both seizures and tumors would be of extreme clinical us
Epilepsy is the most common symptom in patients with brain tumors. ...Low-grade developmental brain tumors are those most commonly as
3,509 results